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Can You Withdraw Ixekizumab in Stable Axial Spondyloarthritis?

d Jack Cush, MD

Remission often invites consideration of drug withdrawal in patients with axial spondyloarthritis (axSpA).

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Lack of Gender Equity in Academic Rheumatology

d Jack Cush, MD

Evidence on gender equity in academic rheumatology in Europe is currently limited. This knowledge gap has a direct effect on the ability of professional bodies to improve gender equity. To address this, EULAR designed a study using web-based surveys to collect information; here are the results.

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Excessive Alcohol-Related Deaths in US Adults

d Jack Cush, MD

Alcohol consumption is a leading preventable cause of death in the U.S.  A JAMA cross-sectional study suggests that between 2015 and 2019, an estimated 1 in 8 total deaths among U.S. adults ages 20 to 64 were attributable to excessive alcohol use, including 1 in 5 deaths among adults ages 20 to 49. 

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EMA Crack Down on JAK Inhibitors

d Jack Cush, MD

The European Medicines Agency’s (EMA's) safety committee (PRAC) has issued a recommendation that the use of oral JAK inhibitors (tofacitinib, baricitinib, upadacitinib and filgotinib) be limited to certain at-risk patients unless no other suitable treatment alternatives are available.

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Follow our newest #ACR22 reporter, Dr. Julian Segan ( @JulianSegan)! “I am looking forward to is meeting all my rheumatology Twitter heroes!” Follow @RheumNow and our reporters for real-time #ACR22 coverage. https://t.co/7axxfOV6W8
Dr. John Cush RheumNow ( View Tweet)
China study of 109 w/ MPO+ vasculitis (MPO-AAV), 23 w/ anti-GBM & 20 Double positive (MPO+ GBM+) (DPP) pts showed DPP pts were older(p=0.007), higher creatinine & lower GFR, & had multi-organ damage (cardiac) outside the kidney https://t.co/3aGPnfVDrs https://t.co/E557RLogCE

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Drug-induced Hepatotoxicity - many Rheum drugs on the list: Tylenol, azathioprine, allopurinol, cyclosporine, dapsone, gold, MTX, 6-MP, NSAIDs, ASA, SSZ, Minocin... https://t.co/wuoVrDgesq https://t.co/SAWPdsQ6I3

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What is RheumNow ACR reporter, Dr. Rachel Tate, most looking forward to at #ACR22? “Onsite, in person learning!” Follow @uptoTate for real-time #ACR22 coverage! https://t.co/nMw015dpdl
Dr. John Cush RheumNow ( View Tweet)
Opportunistic infections in #PsA pts on b/tsDMARDS is low. Metanalysis 47 studies, 17,197 pts - OI risk by MOA:1) JAK inhib 2.72%, 2) anti-IL-17 1.18%, 3) anti-IL-23 0.24% , 4) TNFi 0.01%. H. zoster w/ JAKi= 2.53% & Candida risk w/ IL-17=0.97% https://t.co/a5fJcWTxnL https://t.co/GQKoV7Hg6m

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GSK announced they will halt development of Otilimab (anti-GM-CSF mAb) to treat #RA; decisioin based on negative results from phase 3 ContRAst-3 study, that failed to meet ACR20 primary endpoint in RA pts who failed bDMARDs or JAKi https://t.co/cDqcYKOjSa https://t.co/7rB4TYsWnZ

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Infection: a Leading Cause of Death in Lupus Analysis of a national database of hospital discharges from Spain shows that infections accounted for 25% of lupus deaths, making infection the most common cause of death in SLE. https://t.co/uTQd3afwxR https://t.co/okBHWel62d

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Dr. John Cush RheumNow ( View Tweet)
What's Dr. Dao looking most forward to at #ACR2022? "To covering the meeting and learning of new developments in rheumatology. I am also excited to mentor my medical student on her first ACR meeting where she will be presenting a poster on social media in medical education.' https://t.co/27PcSmJUZe
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Join Dr. Jack Cush and Dr. Arthur Kavanaugh as they discuss, dissect and deliberate about data presented at the #ACR2022 meeting in Philadelphia. https://t.co/yCMStA8yQm https://t.co/myS0sT9BMq

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RheumNow #ACR2022 Reporter Spotlight: Dr. Richard Conway What are you most looking forward to this year at ACR? Dr. Conway: "I'm looking forward to experiencing the enhanced virtual offering this year." Follow him at @RichardPAConway for more ACR RheumNow coverage! https://t.co/xwl8Jqn1Yf
Dr. John Cush RheumNow ( View Tweet)
Chest CT Airway Dz compared betw GPA (n26) & relapsing polychondritis (n19). Subglottic involvement favors GPA (OR 28.6) & Extensive airway Dz favor of RP (GP OR 0.02). Lesser RP assoc w/ Posterior tracheal sparing & tracheal calcifications. https://t.co/TaaEjpPm76 https://t.co/mwljLYIymH

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Increasing Risk of Lupus Nephritis A population based study shows that LN in the US has increased in the last four decades and that LN patients have poorer outcomes with high rates of ESRD and mortality rates 6x that of the general population. https://t.co/aBSUP9ExTh https://t.co/RfgSH0wmOu

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Update to Axial Spondyloarthritis Guidance EULAR and the Assessment of SpondyloArthritis International Society (ASAS) has updated their guidance on axial spondyloarthritis (axSpA) management. https://t.co/iAUXrVp1P3 https://t.co/bHwjI6xJUq

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Dr. John Cush RheumNow ( View Tweet)
New ACR/EULAR Guideline Expands RA Remission Definition Newly released guidance for defining remission in RA is expected to increase the number of patients achieving it while maintaining its ability to predict good objective outcomes. https://t.co/ZZN3kAGW8F https://t.co/iaYUvxYHMq

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Dr. John Cush RheumNow ( View Tweet)
PSOAS study of 354 with long-standing ankylosing spondylitis & SI radiographic changes; but 23 lacked syndesmophytes. Lack of fusion was more likely in women & w/younger age of Sx onset. All were B27+, thus B27 may be assoc w/ SI dz, not spinal dz. https://t.co/QCyTCHjK6u https://t.co/gT3tFuZCDq

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2022 ASAS-EULAR Guidelines for Axial Spondyloarthritis Assessment of SpondyloArthritis international Society (ASAS) and EULAR have published their 2022 update and recommendations for the management of axial spondyloarthritis (axSpA). https://t.co/YI3ZKfaU9k https://t.co/4bbETabYaf

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Dr. John Cush RheumNow ( View Tweet)
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