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#ClinicalPearl Most ordering HCPs don’t know which #ANA is being performed when you order it. Lots of variability. Bottom line IF you DON’T have > moderate risk of #CTD DON’T order it. The FALSE + results will haunt your pt & you & cost 💰#RNL2022 @RheumNow https://t.co/uxMbAdOKcj
Janet Pope Janetbirdope ( View Tweet)
Why do we love to hate #guidelines in #rheumatology - maybe for example in #PsA we really don’t know the BEST Rxas 1st line advanced therapy & beyond. I say: Take a guess or do a pragmatic trial to figure it out. A Kavanaugh #RNL2022 @RheumNow https://t.co/lVIno6FBqJ
Janet Pope Janetbirdope ( View Tweet)
#RNL2022 Drs. Kavanaugh, Ogdie and Kirkham join Dr. Cush for the PsA panel Q & A. https://t.co/0ElGIe21S6
Dr. John Cush RheumNow ( View Tweet)
Cellular source of IL17 in SpA
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/vDMks0RtBb
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Synergetic effect of IL17 and TNF in PSA.
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/acfqiluJWR
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. Bruce Kirkham
Drug Targeting in Psoriatic Arthritis
SEAM PsA study - MTX monotherapy not AS efficacious as MTX and TNFi combo therapy, but STILL effective
@RheumNow #RNL2022 https://t.co/qsSGgD9bq7
Robert B Chao, MD doctorRBC ( View Tweet)
Dr. B. Kirkman reviews research and development timeline for IL17A. I've started explaining this trajectory to patients when discussing "newer" drugs to market that have been around since I was in elementary school. #RNL2022 @RheumNow https://t.co/TgaOYmkBO4
Dr. Rachel Tate uptoTate ( View Tweet)
Dr. Kirkman reviews IL12, IL23, and IL17s. #RNL2022 @RheumNow https://t.co/nFHBzrdz2D
Dr. Rachel Tate uptoTate ( View Tweet)
Excellent graphic on mechanisms of action of PsA and their effects on specific cytokines
@RheumNow #RNL2022 https://t.co/B0ZT6qlpbE
Robert B Chao, MD doctorRBC ( View Tweet)
Use questionnaire if you sense something is not right!!
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/tuBZiA7Dqf
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
T rm cells
▶️Found in skin and joint.
▶️Found in skin and Joint
▶️Unregulated easily in case of inflammation
▶️Releases IL17
▶️Specific role in PSA
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/apFXhzIpFo
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
We always want Real World Data (RWD) but where does this come from? Dr. @AlexisOgdie reviews RWD and RWE (evidence) which "ideally reflects patients we actually see in clinic." #RNL2022 @RheumNow https://t.co/KLJlQ6wzqC
Dr. Rachel Tate uptoTate ( View Tweet)
Enthesitis in PsA is multi-faceted.
Environmental triggers, microbiome, microdamage in combination with innate immune response in genetically susceptible patients can active the IL-23 and IL-17 pathway
Leading to cartilage damage and degradation
@RheumNow #RNL2022 https://t.co/hvkCmJ0V1S
Robert B Chao, MD doctorRBC ( View Tweet)
PSA management:
MTX can be used alone
TNF and MTX are more effective
Other agents
Bruce Kirkham @RheumNow #Rnl2022 https://t.co/rgdylgYDSb
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Get the skinny on THIN. Large EMR database in UK with real world evidence #RWE in #PsA. #Psoriatic arthritis. Teaches about safety, drug retention & comparative effectiveness. Latter is a problem as loss of retention could be ineffective, side effects A Ogdie #RNL2022 @RheumNow https://t.co/V1mYiE3GbI
Janet Pope Janetbirdope ( View Tweet)
This is important in real world practice #RNL2022 https://t.co/YSJgx3QxVx
madan madanpadmajan1 ( View Tweet)
#RNL2022 the true hybrid conference since "before hybrid was cool." @RheumNow @AlexisOgdie @RWCSmtg Dr. B. Kirkham joining us live and by Zoom. https://t.co/6BaYSMFjsR
Dr. Rachel Tate uptoTate ( View Tweet)
RWE (real world evidence) helps in informed disease decisions!! Very interesting!!!!!
@AlexisOgdie @RheumNow #Rnl2022 https://t.co/Pyv2KJz3uO
Nouf Al hemmadi NoufAhmedAlham2 ( View Tweet)
Dr. @AlexisOgdie reminds us the RWE informs tx decisions, methods matter (so review these!), tx outcomes and disease subsets in the real world are important and we need to fill in gaps! #RNL2022 @RheumNow https://t.co/O4ni5EnZmr
Dr. Rachel Tate uptoTate ( View Tweet)
#ClinicalPearl #psoriatic arthritis arthroscopy show cork screw angiogenesis in knee. Active disease w 😜 wild vasculature. Bruce Kirkham also worked on IL17a w several drugs now if #IL17 inhibitors @RheumNow #RNL2022 https://t.co/Hr04RDGD6F
Janet Pope Janetbirdope ( View Tweet)