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Positive Results from the DOA (Duloxetine in OsteoArthritis) Study
A pragmatic, open-label trial of osteoarthritis (OA) patients demonstrated that adding duloxetine treatment seems to be beneficial for end-stage knee OA patients with neuropathic-like symptoms (at risk of central sensitization).
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RheumNow Podcast - RWCS 2022 Roundup (2.19.2022)
Drs. Jack Cush and Artie Kavanaugh review the highlights of the RWCS (Rheumatology Winter Clinical Symposium) from Maui.
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C.D.C. Proposes New Guidelines for Treating Pain; the main msg - use "nonopioid therapies” for chronic & acute pain, including gabapentin, ibuprofen, PT, massage and acupuncture., https://t.co/vJeGeq8mHz
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CSF aptamer (short nucleic acid sequences) discovery of neuropsychiatric lupus pts finds increase in few CSF proteins that are discriminatory -- CSF Lipocalin-2, M-CSF, IgM and complement C3, the latter assoc w/ acute confusional state. https://t.co/Mvp2U8DMh8
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Dr. John Cush RheumNow ( View Tweet)
Using whole gut scintigraphy & gastric emptying studies on 97 systemic sclerosis pts, researchers found 35% had gastroparesis, and these pts also had abnormal transit thru out the GI tract. High anti-CENP-B titers assoc w/ slower gastric emptying https://t.co/lQgQe5Uo9H
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Dr Steen's recipe to dealing with digital ulcers.#RWCS2022 @RWCSmtg https://t.co/fPblrfaFbS https://t.co/rX0hZ7rKl9
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Dr Artie Kavanaugh presents comparison of targeted therapies in different inflammatory disorders. #RWCS2022 @RWCSmtg https://t.co/P4SzIrWzYJ https://t.co/wnf3vnG4xc
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Retrospective study of 98 patients with X-linked agammaglobulinemia (XLA) shows arthritis seen in 46% - more oligo- than polyarthritis, affecting . Knee, hip, and ankle. IVIG response rates around 70%; many w/ arthritis had missense mutation https://t.co/qT49OXLyKU https://t.co/Drz1poV1AH
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Dr. John Cush RheumNow ( View Tweet)
ICYMI: Voriconazole-induced synovitis, enthesitis and periostitis described in woman treated for invasive aspergillosis. She had polyarthralgias, synovitis, and periostitis on xray. Voriconazole prev. caused periostitis; now drug induced arthritis? https://t.co/6HfLGIaEsU
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Dr. John Cush RheumNow ( View Tweet)
Best treatments for NAFLD? WEIGHT loss, but E, pioglitazone, stations, bariatric surgery. And multidisciplinary approach @UmaMahadevanIBD @RWCSmtg https://t.co/ubdFfOrWIu
Dr. John Cush RheumNow ( View Tweet)
NAFLD is increased in #RA. Risk factors include male, BMI, MTX dose, inflammation. @UmaMahadevanIBD @RWCSmtg #rwcs https://t.co/V94aaO5vEH
Dr. John Cush RheumNow ( View Tweet)
When to suspect an interferonopathy (when suspected you should offer an autoinflammatory panel from https://t.co/F9bat3YS1d) #RWCS2022 @RWCSmtg Dr. Susan Shenoi https://t.co/qUts9X8gwJ
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Interferonopathies may respond well to JAK inhibitors. #RWCS2022 @RWCSmtg https://t.co/X64iRs8fNt
Dr. John Cush RheumNow ( View Tweet)
COPA, a rare syndrome w polyarthritis, ILD, pulmonary hemorrhage, w excessive STING signaling. #RWCS2022 @RWCSmtg https://t.co/qjek5MuC7W
Dr. John Cush RheumNow ( View Tweet)
Acardi-Goutietes syndrome type 2 (an interferon party) w mutation presenting as adults, looks like cerebral palsy. Pernio, cerebral calcifications. Dr. Susan Shenoi @RWCSmtg #RWCS2022 https://t.co/x8sF8uWXeU
Dr. John Cush RheumNow ( View Tweet)
Nailfold Capillaroscopy doesnt have to be expensive: use handheld Carson Microbrite (~$10) 10x or 20 x handheld microscope (w/ KY gel) to evaluate #Raynauds #scleroderma https://t.co/8AMsEnaiir https://t.co/JZO0s8xbXA https://t.co/scJTBOD7OS #RWCS2022
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Saphnelo (anifrolumab) has been approved in the European Union as an add-on therapy for the treatment of adult with moderate to severe, active, autoantibody-positive systemic lupus erythematosus (SLE), despite receiving standard therapy.https://t.co/29HupHHOW6
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Dr. John Cush RheumNow ( View Tweet)
Great lecture on disparities in healthcare by Dr Alvin Wells at #RWCS2022 @RWCSmtg - disparities in RA treatment https://t.co/KjvDzbixjc
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Dr Eric Ruderman presents on paraneoplastic syndromes. Many autoantibodies have been possibly implicated. #RWCS2022 https://t.co/R2mfpJLsLo https://t.co/twZLk0v3b6 https://t.co/ex1q8JQDe5
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Challenges in Lupus:
-Mortality greatest in 1st yr
-Dx Delays 6.4 yrs
-Long-term complications increased 50 fold
-Steroids worsen long-term outcomes
-Health care costs increased 3 to 5 years prior to Dx
-Mean delay in drug starts after Dx =177 days https://t.co/ZMHTXBn4vm https://t.co/SX0fSxHoES
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Dr. John Cush RheumNow ( View Tweet)