Retrospective claims analysis shows that psoriasis patients treated with either an IL-12/23 inhibitor or an IL-23 inhibitor had a lower risk of developing incident psoriatic arthritis, compared to TNF inhibitors or IL-17 inhibitors.
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A small cohort trial of rituximab (RTX) in 29 systemic sclerosis patients showed significantly improved skin sclerosis and lung function after a follow-up of 96 weeks.
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Bearing in mind that renal impairment is among the worst complications of ANCA-associated vasculitis (AAV), researchers have identified four different trajectories of kidney function over time in AAV patients, with implications for personalized treatment, as well as future research.
Renal Involvement is Pivotal in ANCA-Associated Vasculitis
Researchers have identified four different trajectories of kidney function over time in AAV patients, with implications for personalized treatment, as well as future research.
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ENT involvement studied in 320 ANCA associated vasculitis pts: 65% had ENT involvement w/ median age =52 yrs, & median BVAS3 = 12. Relapse seen in 29% despite immunosupp Rx. No diff in outcomes betw pts Rx w/ oral or IV CTX or RTX https://t.co/MwZSnVVd32 https://t.co/YbrHxnqDw9
Systemic sclerosis current therapy:
- early dcSSc: MMF, CTX, RTX, TCZ
- rapidly progressive dcSSc - ?Stem cell transpl?
- SSc-ILD: MMF>CTX, possibly nintedanib, perfinidone
- Raynauds w/ digital ulcers: CA channel block, PDE5 inhib, iloprost, Bosentan https://t.co/87giuQR4YZ https://t.co/z2TPlJnu5e
Long-Term Benefit of Rituximab in Systemic Sclerosis
A small cohort trial of rituximab (RTX) in 29 systemic sclerosis patients showed significantly improved skin sclerosis and lung function after a follow-up of 96 weeks.
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I Wanna Get Pregnant
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Managing Septic Arthritis in RA
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QD Clinic - Double Positive, but Few Joints
Lessons from the clinic brought to you by RheumNow Live, March 18 &19, 2023 - Dallas, TX
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Recurrent Fevers; 3 Days at 103F QD Clinic - Lessons from the clinic, brought to you by RheumNow Live March 18 &19, 2023 - Dallas, TX https://t.co/pWrCVrxamD https://t.co/C6q9aVJ2gg
NSAIDs in Pregnancy
Dr. Jack Cush reviews the lastest journal articles, news, and FDA announcements from the past week on RheumNow. This week, the importance of IFNa, Subclinical PsA and NSAID safety during Pregnancy.
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Serum beta-2 microglobulin (B2M) in 100 #SLE pts - strong correlations betw B2M & 24 hr urinary protein, BUN, creatinine, disease activity, & damage score (p < 0.001), & negatively correlated with GFR, C3, C4 (p < 0.001). B2M predicted lupus LN https://t.co/XujdKvjjoS https://t.co/vl8XXQDhXM
2017 Prevalence of Psoriatic arthritis (PsA) in Sweden estimated to be 0.34% (range 0.32-0.50% across all sensitivity analyses); lower in males & w/ higher level of education. 0.24% have seen rheumatology care- 32% on b/ts-DMARDs, 41% csDMARDs https://t.co/Jh2WUYVJR2 https://t.co/ZdFVIq2iQ0
ARTIS Swedish study of Cancer in RA or PSA pts (~15k pts) starting JAKi vs TNFi. With ~2 yrs F/U, the risk of Cancer (excluding NMSC) was similar betw JAKi and TNFi (HR 0.94; 0.65 to 1.38), but more incident NMSC w/ JAKi (HR 2.12; 1.15 to 3.89) at 2 yrs https://t.co/BiPWF1T0lZ https://t.co/nrmaCGBcce
Metanalysis of 3 RCTs & 19 observational studies, showed hematopoietic stem cell transplantation . (HSCT) significantly improved skin thickness and lung function. While HSCT had more deaths than IV CTX, HSCT had higher 2 yr survival rate https://t.co/6qvLJKjFES https://t.co/VHiha5FbUJ
Metanalysis shows Takayasu's arteritis pts are at higher risk of adverse pregnancy outcomes. (27 studies, 825 pregs) showed more miscarriage (16%), hypertension (37%) and pre-eclampsia (14%) in TA patients (p < 0.01) https://t.co/kyUNgcsIPD https://t.co/KA1otftKTc
Study of 197 AAV pts in RAVE trial (RTX vs CTX; followed by AZA) showed most serious infections (82%) occurred in 6 mos (68% Resp infx) & assoc w/ lower#s CD19+ cells. TMP/SMX prophylaxis against P. jirovecii decreased SIE rates https://t.co/oz530OkGs8 https://t.co/YFW7PD6wrW
Massachusetts Medical Society workforce survey (600 MDs) shows that >half have cut back patient time, 55% admitted to burnout (more in women), & 1 in 4 physicians plan to leave medicine in the next two years. https://t.co/VUd101BrEi https://t.co/Hc6UyGMW1E
Periodontal Mucosal Breaks Trigger RA Disease Activity
Periodontal disease (PD) is more common in RA, especially those with anti-citrullinated protein antibodies (ACPAs). RA activity has been linked to the severity of PD and mucosal inflammation.
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