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Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review
A metanalysis shows that social determinants of health adversely impacts patients with lupus nephritis. Lupus nephritis is a significant complication of SLE, often with dramatic increases in morbid and mortal risks. Outcomes are likely to be augmented by social determinants of health, including socio-economic status, and social risk factors.
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Featured BSR Abstracts (5.2.2024)
Dr. Jack Cush muses on the news, journal reports, FDA announcements and the 2024 BSR abstracts just released.
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10 Lupus Tips on May 10 (World Lupus Day) by @LupusMore
https://t.co/mON5ZyTpUE
#lupus #SLE #LupusAwarenessMonth
Links:
Donald Thomas, MD lupuscyclopedia ( View Tweet)
✅ Holistic #Lupus Management in 2024 👍 #LupusAwarenessMonth https://t.co/RY6AcHS9WQ
Laurent ARNAUD Lupusreference ( View Tweet)
Multiplicative Adverse Effects of Social Determinants of Health in Lupus Nephritis: A Meta-analysis and Systematic Review
https://t.co/C6G3VePklU https://t.co/zVoLeI8ZxA
Dr. John Cush RheumNow ( View Tweet)
ICYMI: Tuesday Night Rheumatology- Mastering SLE
This webinar will feature highlights from these lectures followed by live audience Q & A
https://t.co/CLJbtvJKOT https://t.co/hGSK4P7NlF
Dr. John Cush RheumNow ( View Tweet)
CD19 is not expressed on Plasma Cells or Plasmacytoid dendritic cells. Yet, Selective CAR-T cell mediated B cell depletion suppresses interferon signature in SLE !! https://t.co/3DsonHZiWp https://t.co/dk5ZtQRnOm
Dr. John Cush RheumNow ( View Tweet)
SLE Faculty Panel Q&A
https://t.co/2OWlhfmKaP https://t.co/jx6MPDtojS
Dr. John Cush RheumNow ( View Tweet)
FDA issued a drug safety warning linking thiopurine (AZA, 6MP) use in pregnancy & a rare risk of intrahepatic cholestasis of pregnancy (ICP). ICP has been reported in pts w/ CD, UC, or SLE; however thiopurines are not FDA approved for these Dx https://t.co/s37eRuAtQx
Dr. John Cush RheumNow ( View Tweet)
Very late onset Lupus (>60) is less female, less arthritis/dz activity, lower dsDNA, C3, SSA, SSB and ANA but more Sjogrens & RA? Single clinic study of 845 SLE - jSLE (<18), aSLE (18-49), lSLE (50-60), and vlSLE (>60).vlSLE had lowest survival (20yrs) https://t.co/VwDSArDhrc https://t.co/3pSr0xSCKn
Dr. John Cush RheumNow ( View Tweet)
“50% of pts with lupus nephritis are asymptomatic . You have to have a degree of kidney damage before you have proteinuria. Proteinuria does not correlate with intrarenal activity.” – Dr. A Fava #RNL2024 @rheumnow https://t.co/w6UktVozsj
Links:
Dr. John Cush RheumNow ( View Tweet)
Full-read Overview of Macrophage Activation Syndrome - a rare complication of autoimmune inflammatory rheumatic dz; assoc w/ Still’s disease SLE, Kawasaki, dermatomyositis, RA, Sjögren’s. Precipitating factors, including genetics & infections reviewed https://t.co/LmL3BPmo6c https://t.co/OkfwpzNLAL
Dr. John Cush RheumNow ( View Tweet)
"Clinical Pearl!
Lupus flare mimics with Dr. Kahlenberg
- FM
- Stress
- Infection
- Lack of sleep
- Iron deficiency
- Vitamin D deficiency
- Celiac or other concomitant inflammatory disease
- thyroid issues
@Kahlenberglab #RNL2024 https://t.co/byNpSPuzC0"
Links:
Dr. John Cush RheumNow ( View Tweet)
Biology and Rx of Lupus Flares
https://t.co/VlaI1PK8X8 https://t.co/oFXqGUvL4b
Dr. John Cush RheumNow ( View Tweet)
TLR Antagonist in Lupus
An investigational TLR ) antagonist was effective in reducing biomarkers and clinical symptoms of SLE in a pilot trial, evidence that the innate immune system may hold the key to lupus pathophysiology.
https://t.co/QSX3fRXRLs https://t.co/jt5nVer2ZQ
Dr. John Cush RheumNow ( View Tweet)
ICYMI: What are the Early Stages of Lupus?
https://t.co/2ACuh2WirF
Dr. John Cush RheumNow ( View Tweet)
Mexican study 202 #SLE pts shows 89 (45.1%) were hospitalized; their profile was they were younger, shorter Dz duration, higher disease activity scores (SLEDAI), and more damage. Hosp were for Dz activity (61%), Renal Dz, infection, drug toxicity (5.6%)https://t.co/3TKb1ck18V https://t.co/om2R3kfpFY
Dr. John Cush RheumNow ( View Tweet)
Dr. Gabalawy: "How do you know what disease patients will develop in this preclinical autoimmunity state?"
@drdavidkarp ""it's like when weeds pop up in a garden, it's random ...if ACPA Ab pops up, you might have RA, if it's dsDNA, maybe lupus."" #RNL2024 https://t.co/kDkDaDRP8X
Links:
Dr. John Cush RheumNow ( View Tweet)
Low urinary IL16 levels at 12 months predicts kidney survival at 3 years better than proteinuria - @Andreafava @rheumnow #RNL2024 https://t.co/4GLmJQr46C
Links:
Dr. John Cush RheumNow ( View Tweet)
Predicting Infection in Lupus Nephritis
Machine learning (ML) models were applied to 3 cohorts of lupus nephritis (LN) patients and established algorithms to predict co-infection in LN.
https://t.co/BnV7jVfqj1 https://t.co/LYQd6w1DvD
Dr. John Cush RheumNow ( View Tweet)
