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virus,injection,COVID,vaccine

ACR Guidance on Timing of 3rd Dose Booster with Immunomodulatory Drugs

d ACR Press Release

The American College of Rheumatology has issued an updated version of its COVID-19 Vaccine Clinical Guidance for Patients with Rheumatic and Musculoskeletal Diseases following recent recommendations from the CDC that certain immunocompromised patients receive a third dose of an availabl

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Stiffness,hand,MCP,joint,pain

The Predictive Value of Morning Stiffness

d Jack Cush, MD

A prospective study evaluated the value and associations with morning stiffness in patients with clinically suspect arthralgia, and found that the presence of morning stiffness increases the odds of inflammation (as detected by CRP and MRI synovitis).

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Rheumatic Events With Checkpoint Inhibitors: Tumor Type Matters

d MedPage Today

Among the factors that were associated with an increased risk for the development of rheumatic immune-related adverse events following cancer treatment with immune checkpoint inhibitors (ICIs) was the type of malignancy involved, a large case-control study found.

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PSORIASIS.LH_.jpg

Biologic Therapy of Psoriasis May Prevent Psoriatic Arthritis

d Jack Cush, MD

Another retrospective cohort study has shown that biologic treatment of psoriasis may reduce the subsequent incidence of psoriatic arthritis (PsA).

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MTX impairs COVID Vax responses in IMID pts from Ehrlangen & NYU. BNT162b2 mRNA COVID-19 vaccination in rheumatic pts (82) & 206 controls. Adequate immunogenicity seen in IMID & TNFi Rx >90%, but less (50-72%) w/ MTX (45) https://t.co/EvxZSAD6ve

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Dr. John Cush RheumNow ( View Tweet)

#ClinicalPearl My pt’s rheumatoid nodules ⬇️ when she continued off her #methotrexate post #CovidVaccine. She restarted her JAKi + #plaquenil https://t.co/FqNX9k7FUN
Janet Pope Janetbirdope ( View Tweet)
Why do they always say larger RCTs are needed? RCT was >1000 and superiority of Bimekizumab to Secukinumab was shown. Maybe it is better to inhibit more than IL17A with added value of IL17F @RheumNow https://t.co/DAwZKxxinM

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Janet Pope Janetbirdope ( View Tweet)

In the land of a surfeit of free vaccines, this is the dark day when we crossed the line of over 100,000 hospitalizations, more than 25,000 patients in the ICU (highest for the pandemic), over 1300 deaths, and over 186,000 new cases. https://t.co/A8KNIClCwX
Eric Topol EricTopol ( View Tweet)
Cognitive impairment (CI) is not a consequence of having rheumatoid arthritis (OR = 1.12, 0.80–1.58). Population survey study of 4262 adults >50 yrs. 63% of RA had normal cognition , 25% w/ CI, 12% dementia (similar to non-RA- 66%, 22%, 12%) https://t.co/7RFOk8Nrkm

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Dr. John Cush RheumNow ( View Tweet)

A current report in Arthritis & Rheumatology examined the Nurses Health Study II data set and shows that parental smoking, and passive exposure to children, can later lead to an increased risk of adult-onset incident seropositive RA. https://t.co/szl5L7DGJG https://t.co/ScV51iJsA9

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Dr. John Cush RheumNow ( View Tweet)
European Commission approves upadacitinib (Rinvoq)-first JAK Inhibitor for use in adults & adolescents with Moderate to Severe Atopic Dermatitis. UPA is approved for atopic dermatitis in other nations, Russia, Saudi Arabia; pending review in US https://t.co/hiPkJoJCex

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Dr. John Cush RheumNow ( View Tweet)

Rheumatic Events With Checkpoint Inhibitors: Tumor Type Matters https://t.co/vT6185ycoG https://t.co/ImEejSrOPW

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Dr. John Cush RheumNow ( View Tweet)
Given the DELTA breakthrough surge how do you feel about live medical meetings (n> 50) in the next 6 weeks @Janetbirdope @KDAO2011 @psufka @AngusWorthing @RonanTKavanagh @RheumNow @MattieRheumMD @rheum_cat @jeffsparks @hausmannMD @CCalabreseDO @DrSwamyV

Leonard Calabrese LCalabreseDO ( View Tweet)

Among pregnant women, receipt of the BNT162b2 vaccine was associated with a 78% lower risk of incident SARS-CoV-2 infection. Cohort study tincluded 15 060 pregnant women in Israel. No adverse pregnancy outcome difference in Vax Pts https://t.co/jXUjaKIfUV

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Dr. John Cush RheumNow ( View Tweet)

Biologic Therapy of Psoriasis May Prevent Psoriatic Arthritis Another retrospective cohort study has shown that biologic treatment of psoriasis may reduce the subsequent incidence of psoriatic arthritis (PsA). https://t.co/2YbLBsFedv https://t.co/yn47Ipu6K9

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Dr. John Cush RheumNow ( View Tweet)
Novel tech Sorrento's SOFUSA system, in Phase Ib trial, etanercept given by transdermal nanotopography microneedles to deliver higher concentration of drugs to lymphatic system. An enbrel refractory pt treated & showed 34% improved DAS scores https://t.co/S79HUBT7rE

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Dr. John Cush RheumNow ( View Tweet)

CDC: LA county breakthrough COVID infections: In 43,000 new COVID, 10,895, or 25.3%, occurred in fully vaccinated persons, 1,431, or 3.3%, were in partially vaccinated persons, and 30,801, or 71.4%, were in unvaccinated individuals. https://t.co/gbgaV7THch

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Dr. John Cush RheumNow ( View Tweet)

European Commission has approved bimekizumab (Bimzelx) for the Treatment of Adults with Moderate to Severe Plaque Psoriasis. Bimekizumab is a dual IL-17 inhibitor (IL-17A and IL-17F). https://t.co/viRNbx2cbt

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Dr. John Cush RheumNow ( View Tweet)

Most recent numbers from the CDC - The agency said 202,041,893 people had received at least one dose while 171,367,657 people are fully vaccinated as of Tuesday. https://t.co/3rp7QMt84y

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Dr. John Cush RheumNow ( View Tweet)

Safety study of 97 AAV (72 GPA, 25 MPA) pts Rx with Rituxan, median 8 infusions, followed median 3.9 yrs (0.05–4.32). Serious Risks (per 100 Pt-Yrs): serious infections 7.11, cardiac events 5.0, & vascular events 2.37. No deaths related to RTX. https://t.co/WLMQoq79gd

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Dr. John Cush RheumNow ( View Tweet)

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