All News

knee.surgery.jpg (keep)

Biologics Reduce Surgical Needs in RA

d Jack Cush, MD

In Canada, biologic DMARDs (bDMARDs) were introduced after 2001, and since that time there have been significant reductions in hip and knee arthroplasty (THA/TKA) among patients with rheumatoid arthritis (RA), but not in patients with osteoarthritis (OA).

Read Article
COVID vaccine vials

Rare Risk of Serious Adverse Events After COVID Vaccination

d CDC/MMWR

The CDC had reported the Advisory Committee on Immunization Practices (ACIP) study of rare serious adverse events after COVID-19 vaccination and assert that the excessive morbidity and mortality from COVID-19 (and the protection afforded by vaccination) far exceeds the risk of rare safety signals

Read Article
tea

More Tea, Less Rheumatoid

d Jack Cush, MD

A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.

Read Article
SI,Sacroiliac,Erosion,MRI

Early MRI Sacroiliac Improvement with JAK Inhibition

d Jack Cush, MD

The TORTUGA trial tested filgotinib, a JAK1 inhibitor, in active ankylosing spondylitis (AS) patients and was shown to be both effective and capable of retarding sacroiliac (SI) joint erosions as early as 12 weeks.

Read Article
Drs. Jack Cush, Kathryn Dao, Janet Pope, Eric Dein and Yuz Yusof discuss a number of lupus presentations as well as abstracts presented at the virtual EULAR 2021 meeting. Lupus nephritis and treat-to-remission presentations were discussed by the panel. https://t.co/dfRdeveeLp

Links:

Dr. John Cush RheumNow ( View Tweet)

85 rheumatic kids RTX treated - New hypogammaglobulinemia in 27% w/in 18 mos AND 26% w/ infections (half being serious infx). Prior pulse steriods ups risk of inx (OR 15.3) and hypogamma (OR 3.9). Hypogamm predicts risk of SIE (OR 7.9)

Dr. John Cush RheumNow ( View Tweet)

In 206 #SLE pts (mean 62 yrs) polypharmacy (≥10 meds) seen in 35%. 31% used benzodiazepines & 24% opioids. Polypharmacy greater with prednisone, comorbidity & rural. Polypharmacy assoc w/ 4X Benzo & 7X opioid use https://t.co/4U0UakoIRr

Links:

Dr. John Cush RheumNow ( View Tweet)

Takayasu's responds to Tofacitinib - 53 pts given TOF + glucocorticoids (GCs) (n=27) or MTX + GCs (n=26). At 12 mos complete remission (CR) more with TOF (88% vs 56%, p=0.02), w/ lower GC use and relapse rates ((12% vs 35%, p=0.052) https://t.co/qgziyIhKgV

Links:

Dr. John Cush RheumNow ( View Tweet)

Current Israel data for mRNA vaccination in people age >60, 1st to get vaccines >6 months ago, now confronting Delta infections 1. Vaccines work but their apparent effectiveness is diminished over time + Delta 2. Boosters showing some preliminary evidence of working via @dvir_a https://t.co/YKgF9dlFz3
Eric Topol EricTopol ( View Tweet)
Today, the 5 most vaccinated states (14M people) had 580 people in hospital, 12 deaths In the 5 least vaccinated states (16M people)? 6,600 hospitalized, 104 deaths Per capita , least vaccinated states have 10X hospitalizations and 7X deaths So yeah, vaccines are working

Ashish K. Jha, MD, MPH ashishkjha ( View Tweet)

Nice rvw of tx for SSc-ILD by @sclerodermaUM et al Endorse: "MMF is now considered the standard of care as first line therapy for the treatment of SSc-ILD" Reasonable chart, but wish we could offer more HSCT Also, I'm seeing a LOT of INappropriate early use of nintedanib https://t.co/n1R73EbrXZ
Mike Putman EBRheum ( View Tweet)
Smart, concise, insightful short video by Dr Marwan Bukhari (Editor-in-Chief of Rheumatology) on how to write an abstract. https://t.co/M8AUFZsxMF

Links:

Dr. John Cush RheumNow ( View Tweet)

The TORTUGA trial tested filgotinib, a JAK1 inhibitor, in active ankylosing spondylitis (AS) patients and was shown to be both effective and capable of retarding sacroiliac (SI) joint erosions as early as 12 weeks. https://t.co/awfZdiTUBt https://t.co/ST2JIkavhy

Links:

Dr. John Cush RheumNow ( View Tweet)
TB rarely causes arthritis; accounts for 1-5% of all TB (10-30% of pulmonary TB) cases. May present as mono/oligoarthritis, tenosynovitis, dactylitis, Spondylitis (Potts disease), reactive arthritis (Poncets dz) or polyarthritis. https://t.co/RpMrRLQbEa

Links:

Dr. John Cush RheumNow ( View Tweet)

Safety and Tolerability of Subcutaneous Methotrexate A large, single-rheum center analysis of oral and SC MTX use in daily clinical practice suggests that SC MTX has fewer drug discontinuations and is better tolerated compared to other DMARD therapies. https://t.co/TZwZO9j5xd https://t.co/tx9dWoHUj0

Links:

Dr. John Cush RheumNow ( View Tweet)
It was a banner week at the FDA; a new drug approval you should know about; a lot of information about pregnancy and safety; and an interesting case plus a question from one of our readers--this and more in this week's podcast. Let's dive in. https://t.co/5K8ejJ4jj2 https://t.co/RDEM0BMZLC

Links:

Dr. John Cush RheumNow ( View Tweet)
Lumbar Spine Decompression Alone is Superior to Decompression with Fusion https://t.co/EjLoVZaJf5 https://t.co/OJHJl3EWsv

Links:

Dr. John Cush RheumNow ( View Tweet)
Can you manage FM without opioids? Study of 698 Fibromyalgia pts from a tertiary center finds 27.1% taking opioids. Opioid associated with longer Sx duration (>3 yrs), increased age, worse functional impairment & pain catastrophizing https://t.co/N1G4ZtkUE5

Links:

Dr. John Cush RheumNow ( View Tweet)

Delays in Joint Replacement as JIA Patients Reach Adulthood https://t.co/EQNZPD8d7o The JIA category, year of implant, and presence of complications significantly affected implant survivorship. https://t.co/yiD74AElPC

Links:

Dr. John Cush RheumNow ( View Tweet)
FDA issued Drug Safety Communication to statin manufacturers requesting they remove strong warnings against statin use during pregnancy. While statins appear in breast milk, they should not be contraindicated, if needed, during Pregnancy https://t.co/AeFwpsLMXT

Links:

Dr. John Cush RheumNow ( View Tweet)

×