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Why Would Hand OA Be Less Severe in Black People?

MedPage Today

Osteoarthritis (OA) of the hand was less severe according to objective and pain-related markers in Black patients versus those of other racial/ethnic groups after adjustment for known risk factors, researchers found.

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ICYMI: Approximately 61% of patients with rheumatoid arthritis or psoriatic arthritis who use methotrexate report side effects following weekly dosing, including fatigue and nausea, according to data published in Rheumatology and Therapy https://t.co/65OMw9A96h
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Data from 2 phase III studies of psoriatic arthritis using tofacitinib, adalimumab shows that a significant meaningful clinical response is achieved in 29-53 days -- why then are we not making go vs no-go decisions with modern biologics at 6-8 weeks? https://t.co/F56P9c3Rb5
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CARRA Registry looked at TNFi use in JIA and found a nearly 3 fold increased risk of psoriasis. 8225 pts w/ 3.9 yrs of F/U. 54% recv TNFi; the aHR of new onset of psoriasis after TNFi exposure was 2.93 (2.15 to 3.98). MTX had lower risk (HR 0.45) https://t.co/Z6qvlS26M9
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Osteoarthritis Initiative study looked at Hand OA. Among 3588 participants, 41% had hand OA by xray and 12.4 % by Sxs. Over 4 yrs, 27.3 % showed Xray OA progression. More in women (DIPs)>men (MCPs), but less in blacks https://t.co/WRZYcL7zFH
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Scandinavian study of cardiac abnl. in idiopathic inflammatory myopathies showed prolonged QTc abnormalities was more common in IIM pts (16%) & Anti-Mi2, anti-Pl-7, elevated CRP are associated with prolonged QTc (potential biomarkers?) https://t.co/vkEDaum9aY
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Among 10,205 admissions for psychosis, 19% were tested for ANA, 15% of those were ≥1:160; BUT ONLY 4 patients met 2019 ACR/EULAR criteria for SLE, & 2 met criteria for Neuropsychiatric SLE - NPSLE prevalence of 1.5% ANA+ psychosis pts https://t.co/r2sTSVKC66
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NEJM study of ~2000 persons showed that prior PCR proven SARS-CoV-2 infection was effective at preventing Symptomatic Reinfection against alpha variant (90.2%), beta ( 85.7%), delta (92%), but not omicron variant (56%). https://t.co/xlyGmJPRnj
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Retrospective study of 179 antiphospholipid syndr pts, looked at noncriteria findings- their presence incr relapse rates (59% vs 34%;p=0.018) triple positivity & need for Rx. (cytopenias, APS nephropathy, livedo, CNS, Libman Sachs endocarditis) https://t.co/KW6WO1tc1l
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A prospective study of 124 pediatric SLE pts from UK - estimated Incidence 0.36/100 000. In 1st year 71% on systemic steroids, 98.2% on immunosuppressives, 20.4% accruing damage (mostly neuropsychiatric); most needing multiple speciality team care https://t.co/wdh52pn1Fd
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Prevalence of PsA, axSpA & RA (2017) in Norwegian adults is 0.46%, 0.41%, & 0.78%. In 2017, 27.3% of RA patients, 25.7% of PsA patients and 35.1% of axSpA patients used biologic DMARDs (biologics more freq in youngers; infrequent if ≥55 yrs https://t.co/oqlpPmam6R
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