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Data came from the UK Rheumatoid Arthritis Medication Study (RAMS), a prospective cohort of early RA patients starting methotrexate (MTX) shows that in the first year, adverse events (AE) were common, but not serious.
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The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH).
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Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. He discusses the GI side effects of IL-17 inhibitors, downstream revenues from rheumatology care and dietary prevention of gout.
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Two recent analyses from the USA and Canada point to a significant unmet need with regard to pediatric rheumatologists.
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The 2022 ACR/EULAR revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA) have been revised and validated for use in clinical research.
Dr. John Cush
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Hip fractures in elderly occur at >250 000/YR in US w/ a 1-yr mortality rate, 12%-37%. During COVID-19, surgery volumes among older individuals were lower than 2 years previously starting spring 2020 until vaccine was widely available https://t.co/80YQq1gyhA
Dr. John Cush
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The July 2021 RheumNow “Live Vote” surveyed US and non-US rheumatologists on their knowledge and practices when dealing with the bone disorder, X-linked hypophosphatemia (XLH).
https://t.co/6ztalAZrII https://t.co/ONXaGJI15v
Dr. John Cush
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ICYMI: Radiographic progression in AxSpA studied in 101 Spanish Pts - pts w/ sustained low ASDAS had less XRay progression than those with active Dz (2.33 vs 1.76, p=0.027). Long term TNFi use didnt influence progression until the 3rd Yr https://t.co/TchcLL2ivN
Dr. John Cush
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Despite guidelines rec against hyaluronic acid knee injections, HA injx by ortho significantly increased from 1,090,503 in 2012 to 1,209,489 in 2018 (p = 0.04).amongsts Medicare beneficiaries https://t.co/fIEb5pq20I
Dr. John Cush
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Psychosis is rare in SLE; Retrospective cohort review finds 18/709 SLE or 2.5% developed lupus psychosis. Psychosis remitted in 12/18 w/ a combo of antipsyschotic (in 38.9%) and immunosuppressive (steroid 72%, CTX 56%, RTX 17%, etc) https://t.co/AnCPaPS8QE
Dr. John Cush
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BMJ reports that dementia is associated with multimorbidity (>2 chronic diseases) in midlife (before ge 55 yrs)rather than late life; and greater risk with greater multimorbidity before 55 yrs. https://t.co/hCo8b8ufYG
Dr. John Cush
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We are excited to announce that Dr. Philip Mease will be joining us at RheumNow Live, leading a presentation and discussion on Axial Psoriatic Arthritis & Fatigue and Central Sensitization.
Join the discussion on March 19-20, on site or virtually!
https://t.co/3CeULLDgf5 https://t.co/M2ZUoXzlAK
Dr. John Cush
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ICYMI: Top Tweet in January
Clinical trials generally fail in Sjögren's syndrome; but now a study shows that a biologic B cell inhibitor, ianalumab, met its primary endpoint with a dose-related decrease in disease activity (measured by ESSDAI) at week 24.
https://t.co/SLn2qs8En4 https://t.co/nMOUm2C9It
Dr. John Cush
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TB is uncommon in idiopathic inflamm myopathies (3.58%), esp in endemic areas (eg, Asia). Disseminated and Extra-pulmonary (47%) was as common as pulmonary TB (49%); TB Muscle dz seen in 24%. More with M. TB than Non-tuberculous Mycobacteria https://t.co/h6uDsdWj3f
Dr. John Cush
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Retrospective study of 84 pts with Erosive Hand OsteoArthritis (EHOA)- 89% females DIPs erosions scores were higher than PIP’s. Comorbid dz = crystal arthritis (8%), RA (5%) & PsA (1%), Pain usually >5/10 w/ 1/3 responding to NSAIDs. Big Unmet need! https://t.co/jQ3yNgaZBA
Dr. John Cush
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Treatment of Complex regional pain syndrome type-I (CRPS-I) in adults is difficult! A Systematic review shows that only parenteral bisphosphonates (and maybe ketamine) lowered VAS/NRS pain scales vs placebo. https://t.co/m4SpO4P96J
Dr. John Cush
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Persons living with diagnosed HIV (PLWDH) have more hospitalizations and death from COVID-19 than those not HIV+. In 100K PLWDH, 63%) were fully vaccinated, 4% partly Vax & 32% no Vax. VAX in PLWDH was lower than gen population (63% vs 75%) https://t.co/oegf5WjmNF
Dr. John Cush
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In the USA, the prevalence of Vitiligo in adults is between 0.76% (1.9 million cases in 2020) and 1.11% (2.8 million cases in 2020). Approximately 40% of adult vitiligo in the US may be undiagnosed. https://t.co/rsyoIbHmS8
Dr. John Cush
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Radiographic progression in AxSpA studied in 101 Spanish Pts - pts w/ sustained low ASDAS had less XRay progression than those with active Dz (2.33 vs 1.76, p=0.027). Long term TNFi use didnt influence progression until the 3rd Yr https://t.co/KHCdzbqhzr
Dr. John Cush
Tweet
FDA has expanded its approval of REMDESIVIR for use in non-hospitalizedadults and pediatric patients for the treatment of mild-to-moderate COVID-19 disease. Previously, Veklury was limited to hospitalized COVID-19 pts. https://t.co/dHbomchfB5
