Hand Pain Related to Obesity and Inflammatory Markers Save
Arthritis & Rheumatology has published the results of the Nor-Hand study, showing that pain hand osteoarthritis (OA) was related to a higher body mass index (BMI) and also to inflammatory adipokines, such as leptin.
The Nor-Hand study enrolled 281 hand OA patients, assessed their pain in multiple joints, overall pain with several indices, including the WOMAC, NRS and AUSCAN and measured inflammatory biomarkers.
Per 5 unit increase in the BMI hand pain was significantly worse, according to AUSCAN, NRS (foot pain) and WOMAC (assessing knee/hip pain).
Increases in hand and total body joint pain was associated with higher levels of leptin and high-sensitivity C-reactive protein (hs-CRP), especially in the hands.
In hand OA patients, higher BMI was associated with greater pain severity in hands, feet and knees/hips. The biomarker findings suggest that low-grade inflammation, may contribute to generalized pain in overweight/obese individuals.
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