Are antiphospholipid antibodies (aPL) associated with atherosclerotic cardiovascular (ASCVD) event risk? A cohort study has shown that aPL Abs are found in a substantial proportion of adults with ASCVD events and finding both positive aCL IgA and aβ2GPI IgA Abs independently predicted future ASCVD events.
As I was training as a rheumatologist, I found myself drawn to rheumatologic disorders in older patients. In particular, I was intrigued by programmatic development that could improve both disease outcomes and older adults’ quality of life. This was not the “sexiest” topic in rheumatology and it was hard to figure out how to get started. I was extremely fortunate to find a mentor.
Sensitive women and stoical men are the prevalent images of people in chronic pain. Unwarranted differences in medical treatment may result, as a University of Gothenburg doctoral thesis emphasizes.
Fibromyalgia is a mysterious chronic pain disorder that is difficult to treat. Its causes are also still largely in the dark. A study conducted by the team at the Clinic for Psychosomatic Medicine and Psychotherapy at Ruhr University Bochum, Germany, provides evidence that certain brain areas involved in processing pain don’t function normally in fibromyalgia patients.
Dr. Megan Clowse from Duke University talks about changing how she talks to patients with lupus, exploring and treating two types of lupus.
When I first took on the role as the American College of Rheumatology (ACR) Committee on Government Affairs chair, I was keenly aware of being the first woman to be nominated to this position. While the demographics of government officials have changed over the past several decades, governance positions are held overwhelmingly by men. Having my voice heard and advocating for my colleagues at the ACR, and most importantly for our patients, were
BRIDGE-PMR proof-of-concept trial assessed the efficacy of rituximab (RTX) in patients with polymyalgia rheumatica (PMR) and showed that a single 1000 mg dose of lead to a significant number of glucocorticoid-free remissions after 1 year.
British Society for Rheumatology (BSR) last published its guideline for systemic sclerosis (SSc) in 2016. Given the many advances in the field the BSR has outlined their plans to update the management of SSc.
The EMA has updated recommendations regarding the use of JAK inhibitors by issuing a direct healthcare professional communication summarizing the data and warnings regarding an increased risk of malignancy, major adverse cardiovascular events (MACE), serious infections, VTE, and mortality in some patients receiving JAKi for the treatment of chronic inflammatory disorders.
Origin stories have captivated me ever since my childhood spent reading Greek Mythology and Marvel comic books. Superheroes have different powers and personalities. Some could fly, others were strong and seemed invincible, most were intelligent, but all fought for the good of humanity.
Dr. Jack Cush reviews the CV advantage to walking, the OA risk with running and the eczema-OA connection; these articles and journal reports from the past week on RheumNow.com.
Does serum urate elevation differ with different types of alcohol consumption? A Japanese study shows beer and wine was associated with high and moderate increases in uric acid but less so with sake.
A number of new reports this month shed new light on old issues in Gout.
Analysis of commercial insurance claims suggests that patients with asthma or atopic dermatitis have a significantly increased risk of osteoarthritis.
NIH researchers have have described a novel autoinflammatory disorder called "Lyn kinase-associated vasculopathy and liver fibrosis" (LAVLI), based on a mutation in the LYN gene (that encodes the Lyn kinase protein). They discovered that increased Lyn kinase activity promotes systemic inflammation, by altering microvascular permeability and neutrophil recruitment, while at the same time promoting hepatic fibrosis.
