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Fatigue is Driven by Inflammation, Pain, and Chronicity in Psoriatic Arthritis

Jul 19, 2019 3:00 am

Correlates with fatigue were assessed in psoriatic arthritis (PsA) patients in the DANBIO registry and found to be associated with  clinical inflammatory factors, disease duration, and chronic pain.

A toital of 2062 PsA patients in the Danish nationwide registry DANBIO were studied by cross-sectional survey from December 2013 to June 2014.

Ultimately there were into three co-variables explaining 63% of fatigue in PsA patients:

  1. 31% of fatigue was linked to inflammatory factors (swollen and tender joints, MD global assessment, elevated CRP)
  2. 17% of fatigue was related to increasing age and long disease duration
  3. 15% was associated with chronic pain variables - i.e., high PDQ score, tender joint count, etc.

Fatigue in PsA patients may be driven by clinical inflammatory factors, disease duration, and chronic pain in the absence of inflammation.

(Editors note: the primary drivers of fatigue in the vast majority of patients with musculoskeletal symptoms are a) poor sleep; b) depression; and c) inflammation)

The author has no conflicts of interest to disclose related to this subject

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