Labs/Biomarkers

EULAR 2023 – Day 3 Report

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Day 3 was a sunny warm day in Milan at the 2023 EULAR Congress meeting. Here are a few of my favorite abstracts from today.

EULAR 2023 – Day 2 Report

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Day 2 at the international EULAR Congress meeting is always bigger and busier. There were sessions on JIA therapies, crystal arthritis, novel drugs for SLE and Sjogren's, early RA and preclinical RA interventions, IgG4 disease, osteoporosis and the growth and application of artificial

International Consensus on ANCA-Associated Vasculitis with Glomerulonephritis

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Nephrology Dialysis Transplantation has published an overview of the management of anti-neutrophil cytoplasmic antibody associated vasculitis with glomerulonephritis based on several international guidelines, including those frorm the ACR 2021, EULAR 2022 and KDIGO 2021 (Kidney Disease:

Allergic Drug-Induced Arthritis (5.19.2023)

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Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  This week we delve into some odd associations, repeat drug warnings and the consequences of antirheumatic therapies.

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   Subanalysis of the tofacitinib ORAL Surveillance study shows the JAK

Evidence-Based Guidelines for EGPA

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Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare form of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, affecting between 10 and 14 cases per million globally. This adult disorder has a mean age at diagnosis of nearly 50 years and affects both sexes equally,

Low Risk of Venous Thromboembolism with IVIG and Dermatomyositis

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A cohort study analyzed the risk of venous thromboembolism (VTE) in dermatomyositis (DM) patients treated with intravenous immunoglobulin (IVIG).

Previous studies have shown an increased risk of VTE in DM patients, usually within 2 years of onset. Moreover, the FDA has recently

National Population Insights (4.28.2023)

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Dr. Jack Cush reviews the news and journal reports and addresses 3 viewer case questions.

Renal Function Safe With Pegloticase-MTX Combo for Gout

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For patients with uncontrolled gout, estimated glomerular filtration rate (eGFR) remained stable with combination pegloticase (Krystexxa) and methotrexate treatment, researchers reported.

Looking more closely at the 12-month findings from the MIRROR trialopens in a new tab or window 

Clinical Profile of RA-associated Interstitial Lung Disease

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A prospective, cross-sectional analysis of patients with rheumatoid arthritis (RA) shows those with interstitial lung disease (ILD) tend to be older, obese and have a smoking history.

A single-center cohort study of 148 RA-ILD and 410 RA-non ILD patients compared clinical features

Antiphospholipid Antibodies With Incident Cardiovascular Events

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Are antiphospholipid antibodies (aPL) associated with atherosclerotic cardiovascular (ASCVD) event risk?  A cohort study has shown that aPL Abs are found in a substantial proportion of adults with ASCVD events and finding both positive aCL IgA and aβ2GPI IgA Abs independently predicted future

Steroid-Sparing Rituximab in Polymyalgia Rheumatica

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BRIDGE-PMR proof-of-concept trial assessed the efficacy of rituximab (RTX) in patients with polymyalgia rheumatica (PMR) and showed that a single 1000 mg dose of lead to a significant number of glucocorticoid-free remissions after 1 year. 

BRIDGE-PMR was a 21 week randomised

Alcohol Differences in Urate Level Elevation

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Does serum urate elevation differ with different types of alcohol consumption? A Japanese study shows beer and wine was associated with high and moderate increases in uric acid but less so with sake.

A cross-sectional study of Japanese adults (over age 20 yrs) examined effects of

Gout - Hot Topics in March 2023

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A number of new reports this month shed new light on old issues in Gout.

LAVLI - A New Autoinflammatory Disorder

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NIH researchers have have described a novel autoinflammatory disorder called "Lyn kinase-associated vasculopathy and liver fibrosis" (LAVLI), based on a mutation in the LYN gene (that encodes the Lyn kinase protein). They discovered that increased Lyn kinase activity promotes systemic

Anti-mesangial autoantibodies in IgA nephropathy

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IgA nephropathy (IgAN) is a kidney disorder characterized by the buildup of immunoglobin A (IgA) in the glomeruli, which are bundles of capillaries that filter blood in the kidney. In advanced stages of the disease, the buildup of IgA in the glomeruli disrupts kidney functioning and, in

2022 EULAR Recommendations for ANCA-associated Vasculitis

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EULAR has published the 2022 update on recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).

AAV recommendations were last published in 2016, and since, research and clinical trials have advanced our understanding of AAV.  A

A Pilot Trial of Anifrolumab in Discoid Lupus

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A research report in JAMA Dermatology describes the use of the type 1 interferon receptor inhibitor anifrolumab in patients with chronic discoid lupus erythematosus (DLE). 

Long-Term Survival of Idiopathic Inflammatory Myopathies

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A single center cohort study analyzed the outcome and survival of idiopathic inflammatory myositis (IIM) patients and showed good 5 and 10 year survival but showed significant declined 15-25 years post-diagnosis.

This was a retrospective single-centre analysis of IIM patients

Geo-epidemiology of Autoantibodies in Rheumatoid Arthritis

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A multinational study of rheumatoid arthritis (RA) patients shows a variety of post-translationally modified anti-modified protein antibodies (AMPA). While AMPA differed in different ethnic populations, their levels correlated with total serum IgG.