Labs/Biomarkers

🔬 Can baseline T cell phenotype predict PsA treatment response? COLIPSO cohort (n=17): YES! Higher Treg & activated CD4+ cells predict DAPSA & joint improvement #POS0083 #EULAR2026 @RheumNow https://t.co/UIs6LXAWAY

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
Window of opportunity in stills disease is early. With IL1 / IL6 agents #sJIA and #AOSD are the same disease. - may need a standard new crieteria IL18 measuremnet should be encouraged. @RheumNow #EULAR2026 plenary https://t.co/EQbs9mDYjS

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Bella Mehta @bella_mehta( View Tweet )
Who should we screen for RA-ILD? RA-ILD remains a serious extra-articular manifestation, contributing to morbidity and mortality. At #EULAR2026, two abstracts shed light on clinical phenotyping and risk profiling. Read my report for @RheumNow: https://t.co/CTtYHINXxU

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Mrinalini Dey @DrMiniDey( View Tweet )

🧬 Do biomarkers predict #zasocitinib response in PsA? YES: TYK2/IL-17 pathway markers predict ACR20 in 290pts Phase 2b RCT #OP0184 #EULAR2026 @RheumNow https://t.co/AVlyrauI5q

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
🔎 Can US predict PsA progression from psoriasis? YES: synovio-entheseal inflammation predicts progression in 183pts prospective cohort #OP0183 #EULAR2026 @RheumNow https://t.co/7B9KU60qFd

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
Defining the TRM- SLE patient response. Patient eligibility would be the key #EULAR2026 @RheumNow https://t.co/5CzQYgc12K

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Bella Mehta @bella_mehta( View Tweet )
DESIR Cohort 10-year data (OP0102): SIJ structural lesions in #axSpA progress slowly, but prior MRI bone marrow oedema predicts later structural damage. bDMARD exposure was associated with less erosion progression supporting early biologic treatment Abstr OP0102 @RheumNow

Antoni Chan MD (Prof) @synovialjoints( View Tweet )

#EULAR2026 OP022 We need to think beyond proteinuria to assess activity & response in #lupusnephritis. ReBioLup study showed 67% of patients with persistent histologic activity at 12 months (NIH=>4) still met criteria for complete clinical response @RheumNow https://t.co/bRFNrNLjJX

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
#EULAR2026 OP0228 Is there “something in the air?” Data from US Market Scan: poor quality index was associated with increased risk of #SLE. Although causal inference cannot be deduced, seems an important environmental factor. To check air quality assoc with UV index @RheumNow https://t.co/1FOw7RDA9a

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Which ‘CAR’ to drive in #SLE? Comparison of #CD19 #CAR-T #allogenic vs #Autologous ➡️ comparing #molecular #responses from 2 #lupus studies N=12 Both improved cytokine signatures For #IFN & #neutrophils Results similar not identical ?either #POS0678 #EULAR2026 @RheumNow https://t.co/Lcpv3qJ6tU

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Janet Pope @Janetbirdope( View Tweet )
#OP006 - Urine proteomics in LN tracks histo activity & treatment response better than proteinuria. Paired biopsies linked active disease to IFNI, IL12, complement & neut pathways- normalised in responders but persisted in non-responders. @RheumNow #EULAR2026 #EULARBest #Plenary

Mrinalini Dey @DrMiniDey( View Tweet )

🔬 Does synovial biopsy-guided treatment outperform standard care in PsA? YES - 68% vs 45% DAPSA remission/LDA in 45pts OP071 #EULAR2026 @RheumNow https://t.co/cLCR7I8QAm

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
#EULAR2026 OP002 In 20 active #lupus nephritis patients with paired kidney biopsy at baseline & 1 yr, urine proteomics showed histology response correlated with restoration of immune, coagulation and ECM-remodelling pathways. Need to advance this liquid biopsy in clinic @RheumNow https://t.co/KaZSYlA9V1

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
ACPA and the Transition from Arthralgia to Rheumatoid Arthritis Patients with clinically suspect arthralgia (CSA), a common prequel to rheumatoid arthritis (RA), showed different patterns of symptoms and progression depending on whether they tested positive for https://t.co/pCaYdEg1gZ
Dr. John Cush @RheumNow( View Tweet )
#EULAR2026 OP0125 It’s a case of “teamwork makes the dream work!” Instead of an index to capture heterogeneity in #Sjogren activity, the NECESSITY validated using data from 16 RCTs that a new composite tool, STAR has high sensitivity & specificity. Vital for use in RCTs @RheumNow https://t.co/ftx1uBP11A

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
🔍 What defines a positive MRI for #axSpA? SPARTAN-SSR consensus (n=1,050): BME≥3 slices or 2/3 lesions in ≥3 SIJ quadrants #OP0100 #EULAR2026 @RheumNow https://t.co/nfhzGxBZOm

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
HLA-Cw6: a marker of more severe and difficult to manage psoriatic arthritis? POS0484 #EULAR2026 @RheumNow https://t.co/MIYZxuYT4v

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Nelly ZIADE 🍀 @Nellziade( View Tweet )
Psoriatic arthritis #PsA sessions raised important topics on intercepting arthritis in psoriasis, treating obesity as a disease target, synovial biopsy to guide treatment, molecular imaging to reveal subclinical disease. More tomorrow. #Rheumatology @RheumNow #EULAR2026

Antoni Chan MD (Prof) @synovialjoints( View Tweet )

❎HIGH Type 1 #interferon = Worse #scleroderma In both #limited #lcSSc & #diffuse #dcSSc Leeds cohort ?biomarker #EULAR2026 @RheumNow ABST#POS1092 ABST#POS0395 https://t.co/cRrBIpLgP9

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Janet Pope @Janetbirdope( View Tweet )
#OP088 at #EULAR2026 found that rare deleterious variants in telomere-related genes were associated with increased RA-ILD risk, independent of MUC5B status. The effect size was similar to that seen in idiopathic pulmonary fibrosis. @RheumNow

Mrinalini Dey @DrMiniDey( View Tweet )

Multiparametric renal MRI in LN: Structural MRI can differentiate bet. active and stable dse Exudative = active inflamm In quanti analysis, low ADC values may reflect fibrosis. A potential non-invasive biomarker? OP092 @rheumNow #EULAR2026 https://t.co/IarTGOen7v

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sheila @RHEUMarampa( View Tweet )
#OP087 explored cancer polygenic risk scores (PRS) in RA. RA was assoc with lower risks of breast and colorectal cancer across all PRS categories, while high prostate cancer PRS may identify RA patients with increased early prostate cancer diagnoses. @RheumNow #EULAR2026 https://t.co/WMqqSFADlW

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Mrinalini Dey @DrMiniDey( View Tweet )
68Ga-RGD PET/CT in PsA reveals large chunk of “silent” synovitis 15 pts 1020 joints 35% affected joints clinically silent PET signal correlation w/ disease burden: DAPSA (ρ=0.66) CRP (ρ=0.69) Pilot study — not confirmed with US Needs validation but intriguing signal #OP068 https://t.co/nhS7PDZN0A

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Aurelie Najm @AurelieRheumo( View Tweet )
Kicking off Clinical Abstracts: Comorbidities in RA session at #EULAR2026 with #OP084 ANCHOR-RA found 9.1% at-risk RA patients had previous undiagnosed ILD on screening HRCT. Older age, smoking, male sex & ⬆️DAS28 linked to RA-ILD. Important data for earlier detection @RheumNow

Mrinalini Dey @DrMiniDey( View Tweet )

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Progress of biologics/targeted therapy in SLE

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We are in a transformative era in SLE which generates excitement to both physicians and people living with lupus. We now have four licensed biologics/targeted therapies (i.e., belimumab, voclosporin and obinutuzumab for active lupus nephritis, and belimumab and anifrolumab for active non-renal

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