Labs/Biomarkers

Dr. John Cush Tweet
@RheumNow
Beyond HLA-B27: Anti-14-3-3eta Autoantibodies as a Candidate Marker in axSpA 14-3-3 proteins are a conserved family of seven isoforms with diverse cellular functions, found predominantly intracellularly. The 14-3-3eta isoform has been studied as a proinflammatory mediator in RA https://t.co/yC4bhtnTCD
Antoni Chan MD (Prof) Tweet
@synovialjoints
ACR26 summary, AI and documentation: errors on all five AI platforms tested against guidelines, and cDAPSA documented in 4.9% of PsA records @rheumnow #ACR26 Abstract#0869 Abstract#1348
Akhil Sood MD, MS Tweet
@AkhilSoodMD
Erosions and seronegative RA? Abstract 2932 found anti-MFN1 - IgG a/w with inc risk of radiographic erosions at baseline (OR 3.04) & 2 years (OR 3.24) + the adjusted model - IgA a/w erosive disease at baseline only; higher erosion score at baseline & 2 years @RheumNow #ACR26
Daric Mueller, PA-C Tweet
@rheumPAC
(1/2)#ACRBest Dazodalibep (DAZ) for systemically active SjD Ph3 top line results! LB22 648 pts IV DAZ 1500mg Q4W or 3000mg Q12W vs placebo Signf improved ESSDAI in both DAZ arms @ 48W. ESDAI differences vs placebo -1.8 for 1500mg Q4W, -1.4 for 3000mg Q12W @RheumNow #ACR26
Mrinalini Dey Tweet
@DrMiniDey
In 60 RA patients, grayscale ultrasound correlated with biopsy inflammation in early and refractory disease. Power Doppler correlated only in early RA. Biopsies with high ultrasound scores but little inflammation often showed scar tissue. #2934 @Rheumnow #ACR26
Mrinalini Dey Tweet
@DrMiniDey
Higher orosomucoid-1 levels were associated with future difficult-to-treat RA in two cohorts (n=198). Samples were taken years before D2T criteria were met. Independent validation using ELISA showed an AUC of 0.86. #2933 @Rheumnow #ACR26
Mrinalini Dey Tweet
@DrMiniDey
Anti-mitofusin-1 IgG was found in 9.7% of 638 ESPOIR patients with early arthritis. In RF/ACPA-negative patients, positivity was linked to higher odds of erosions at 2 years (aOR 3.47; 95% CI 1.17-11.0). A potential marker of erosive seronegative RA. #2932 @Rheumnow #ACR26
Adela Castro Tweet
@AdelaCastro222
Lip biopsy for Sjogren's disease diagnosis? Great debate at #ACR26 @RheumNow
Mrinalini Dey Tweet
@DrMiniDey
Do we have a marker for RA-ILD severity? Higher MMP7 was assoc with greater CT involvement and lower DLCO; not FVC or respiratory symptom scores. HRCT & DLCO also more sensitive indicators of RAILD progression and severity than FVC and respiratory PROs #2886 @Rheumnow #ACR26
Audrey Gibson Tweet
@Gibson_RheumPAC
Jamaly et al investigated P-selectin glycoprotein ligand-1 as a noninvasive marker of lupus nephritis, with multi-institutional validation. Could we detect renal inflammation earlier and reduce reliance on biopsy? @rheumnow #ACR2026 Abstract#LB06
Bella Mehta Tweet
@bella_mehta
ACR26 Abstract #2243: Can AI see more in an ANA image than we do? Deep-learning models predicted several specific autoantibodies directly from HEp-2 immunofluorescence images, including anti-dsDNA with an AUC of 0.902. Exciting potential for laboratory triage @RheumNow

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