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RECOVERY study of hospitalized COVID-19 pts compared colchicine to PBO (+usual care). Colchicine had no effect on 28d mortality (21% vs 21%), time to D/C(10 d vs 10d), LIve D/C (70 vs 70%), mechanical vent or death (25 vs 25%) https://t.co/dYZglKzwxC
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
JAMA reports the COVID-19 combined infection- and vaccination-induced seroprevalence estimate in May 2021 was 83.3% By May 2021, there were 2.1 SARS-CoV-2 infections per reported COVID-19 case. https://t.co/bUZ5AqYnxM
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
EULAR has updated its recommendations (points to consider - PtC) for rheumatologists managing patients during COVID-19; now with 2 overarching principles and 12 PtC.
Read more on #RheumNow
https://t.co/Q422Sl5Csj
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
In case you missed it…
Still’s Disease Following COVID-19 Vaccination
Read more on #RheumNow
https://t.co/23R41Pydve https://t.co/a44cYIkc98
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
For best practices in managing the Delta wave, the US would have done well to consult Puerto Rico
US 26 cases/100,000 people, 19/100K hospitalized 57% vaccinated
PR 3 cases/100,000 people, 3/100K hospitalized, 68% vaccinated https://t.co/kqlXBlmYpu
Eric Topol @EricTopol ( View Tweet )
2 years 6 months ago
A case of reactive arthritis following COVID-19 infection; manifest as dactylitis, psoriatic skin/nail lesions, painful oral & vaginal ulcers, subungual hyperkeratosis, but no oligoarthritis, or lumbar pain. https://t.co/nobMHGgKfZ
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
Could Auranofin work in COVID-19 infection? it may do so by inhibiting IL-6 production, as auranofin inhibits TLR3/TLR4, STAT3/JAK1 and thioredoxin reductase that regulates NF-kB (later IL-6); and may inhibit viral replication too. https://t.co/efLG4tzpTZ
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
Anakinra appears to lower mortality risk (OR 0·32 vs historic controls) in hospitalized severe COVID-19 pneumonia (esp w/ hyperinflammation, CRP >100 mg/L). Metanalysis of nearly 2000 pts; better resp if given w/ dexamethasone (OR 0·23) https://t.co/7nFAkLgpGK
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
WHO's Strategic Advisory Group on immunisation has advised an addition COVID vaccination in those >60 years and the immunosuppressed (due to a higher risk of breakthrough infections) https://t.co/NcGr8EMDaO
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
SLE hospitalized with ARDS from COVID-19 have significantly higher risks of death and poor outcomes (RR=1.7), compared 319 SLE vs 251,800 nonSLE - SLE was more impactful than other comorbidities in such poor outcomes https://t.co/8VJjdOmTbi https://t.co/jYTg6k1QNq
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Dr. John Cush @RheumNow ( View Tweet )
2 years 6 months ago
