COVID-19 and the Slippery Road of Cytokine Storms
Early reports on the COVID-19 pandemic allude to a cytokine storm or hyper-inflammation, especially in patients who succumbed to the illness.
Lower Risk of Diabetes with Abatacept
Patients with rheumatoid arthritis (RA) treated with abatacept (Orencia) had a lower risk of developing diabetes mellitus compared with those receiving certain tumor necrosis factor (TNF) inhibitors, a large cohort study suggested.
Post 9/11 Autoimmune Disease Risk
The 9/11/01 terrorist attach on the World Trade Center (WTC) resulted in at least 2,977 fatalities, over 25,000 injuries, and caused at least $10 billion in infrastructure and property damage. Arthritis & Rheumatology reports that dust cloud exposure among responders and
RheumNow Podcast – The Beginning of Something Else (4.10.20)
Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com
TNR - Grand Rounds: Safety of Biologics & New Agents
On Tuesday, April 7th, RheumNow hosted its first Tuesday Nite Rheumatology webinar - kicking off a two-month series of Rheumatology Grand Rounds lectures. The first session featured Jack Cush, MD (UT Southwestern) who lectured on "The Safety of Biologics and Newer Agents".
NICE Guidelines on Managing Rheumatologic Conditions During COVID-19 Pandemic
On April 3rd, the National Institute for Health and Care Excellence (NICE) in the UK, published a rapid guideline for managing children and adults with rheumatological autoimmune, inflammatory and metabolic bone disorders during the COVID-19 pandemic, while protecting staff from infection.
The Immunologic Basis of Wellness in the COVID-19 Era
We indeed are living in interesting times and we all are seeking not to contract COVID-19 - this is logical. While our goal is to avoid infection, I think we all must agree that our aspirations must encompass more than disease avoidance.
RheumNow Podcast – Pandemic Numbers (4.3.20)
Dr. Jack Cush reviews the news on COVID-19 and FDA actions this past week. Be sure to check out:
CDC: Impact of Underlying Health Conditions Among COVID-19 Patients
The March 31 release of the Morbidity and Mortality Weekly Report (MMWR) reviews the impact of several key comorbidities, most commonly diabetes mellitus, chronic lung disease, and cardiovascular disease, as cofactors leading to worse outcomes with COVID-19 infections. Below are e
Telemedicine Bloopers and Successes
At my COVID home command center, I feel pretty prepared for everything. From here, I can run my practice, manage and home-school 3 children and keep the family afloat.
RheumNow Podcast – New World Order (3.27.20)
Dr. Jack Cush reviews the news and COVID developments from this past week.
RheumNow PSA - 1-4 patient support announcements on dealing with medications, their health, COVID, Safety, Myths and Stress.
Social
SLE: Belimumab + standard rx significantly⬇️risk of severe flares vs placebo.
Greatest in those with:
🔹+dsDNA
🔹low C3 or C4
🔹SLICC/ACR Damage index of 0 (argument for early treatment!)
https://t.co/UcGXEklqwJ
#ACR21 Abst#1295
@RheumNow
Pedro Castillo @_Castillo_Pedro ( View Tweet )
3 years 10 months ago
Trauma associates with subsequent increased flares of SLE. Abstr#1446 #ACR21 @RheumNow https://t.co/QeNXOjHAjn
Richard Conway @RichardPAConway ( View Tweet )
3 years 10 months ago
#volcosporin good ~lupus nephritis added to #MMF but underbelly - side effects like but ?less than #cyclosporin. #FDA update - ⬆️hypertension and nephrotoxicity, infection #ACR21 @RheumNow https://t.co/w5nLLSTlrB
Janet Pope @Janetbirdope ( View Tweet )
3 years 10 months ago
BAFF & APRIL support B cell development, diff, survival.
ALPN-303: Antagonist of both BAFF & APRIL
💠⬇️B cell fxn & Ab production,⬇️Plasma cells
💠⬇️UProt, dsDNA, renal immune complexes (mouse model)
💠Pending human studies
https://t.co/kzVpUDuNWs
#ACR21 Abst#1429 @RheumNow
Pedro Castillo @_Castillo_Pedro ( View Tweet )
3 years 10 months ago
Are you using less #rituximab in #SLE during #COVID #ACR21 @RheumNow #Lupus hub
Janet Pope @Janetbirdope ( View Tweet )
3 years 10 months ago
"Baseline and routine EKGS are NOT required for SLE patients just because they are on HCQ!" - Dr. HM Belmont. "The drug has been demonized due to its use in COVID patients. We don't need to hold HCQ for EMR alerts (e.g, with cipro, SSRIs, etc)." Abstr#1743 #ACR21 @rheumnow https://t.co/5Bxavo6dRg
TheDaoIndex @KDAO2011 ( View Tweet )
3 years 10 months ago
#PJP prophylaxis debate at #lupus hub if on #prednisone + immune suppression. #SLE has ⤴️septra side effects. Don’t know right answer. NNT v NNH is unknown. I don’t use it in #SLE. @RheumNow #ACR21 8M212
Janet Pope @Janetbirdope ( View Tweet )
3 years 10 months ago
#SLE study hub re #Lupus nephritis rocks. #Rituximab ⬇️antiDNA but then rebound ⤴️. Thus design of adding #belimumab to Rituximab=Less flares. Love the Hubs. #ACR21 @RheumNow https://t.co/MAhxJdmkWO 10.7326/M21-2078 #ACRBest https://t.co/qWPk5x1ZtM
Janet Pope @Janetbirdope ( View Tweet )
3 years 10 months ago
#ACR21 Ab#1029 - Great poster by Dr. Guttmann, IRAD in Summit NJ:
▶️2019 EULAR/ACR SLE criteria vs to 1997 ACR & SLICC
⭐️64% SLE pts: all 3 criteria. 10% only SLICC, 3% '97 ACR, 2% EULAR/ACR
⭐️Simliar gender, racial disparities to prior criteria
@Rheumnow https://t.co/QzG78HJgw5 https://t.co/eyuYhj4Acf
Links:
Eric Dein @ericdeinmd ( View Tweet )
3 years 10 months ago
#ACR21 Abst#1029 @Rheumnow https://t.co/QzG78HJgw5
What is your preferred SLE classification criteria?
Links:
Eric Dein @ericdeinmd ( View Tweet )
3 years 10 months ago
