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Dermatology

Cardiovascular Risk in Cutaneous Lupus Erythematosus

A retrospective study of cutaneous lupus erythematosus (CLE) patients finds an increased risk of atherosclerotic cardiovascular disease (ASCVD) on par with systemic lupus patients.

An IBM MarketScan Commercial Claims data analysis from 2018 to 2020 included

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Fallen Angels (1.17.2025)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com; and pays homage to colleagues who passed away in 2024.

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Childhood Maltreatment and the Risk of Rheumatic Diseases

EurekAlert!

A UK retrospective matched open cohort study shows that children who suffered frmo abuse, neglect or domestic abuse carry a significantly increased risk of developing rheumatoid arthritis or psoriasis in later life.    

Researchers used Dexter software and over 16 million

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Dazukibart Effective in Adults with Dermatomyositis

Lancet reports that the use of dazukibart, a selective monoclonal antibody against interferon B (IFNβ), was clinically effective in reducing disease activity in adults with active dermatomyositis (DM).

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Alive in 2025 (1.10.2025)

Dr. Jack Cush brings in the new year with a review of the latest from RheumNow.com

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Anti-Zoster Drug Prevents Shingles in Lupus Patients on Anifrolumab

MedPage Today

The antiviral drug valaciclovir (Valtrex), given prophylactically, kept patients with systemic lupus erythematosus (SLE) under treatment with anifrolumab (Saphnelo) from having herpes zoster attacks, researchers said, offering a potential alternative to zoster vaccination.

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Phase 3 Trial Results of Deucravacitinib in Psoriatic Arthritis

Bristol Myers Squibb announced recently the results from POETYK PsA-1 and POETYK PsA-2, Phase 3 trials pivotal trials of deucravacitinib (DEUC) in adults with active psoriatic arthritis. Both trials met their primary endpoint, demonstrating ACR20 efficacy after 16 weeks of treatment with DEUC

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JAK inhibitors are effective at repigmentation in vitiligo. 5 RCTs, 1,550 pts showed >50% improvement (TVASI50; RR 2.67) or >75% (FVASI75; RR 3.97_ JAKi increased skin AE, but not significantly different from placebo pts. https://t.co/zIreYlUyLt https://t.co/pCWKL2vSVs
Dr. John Cush @RheumNow( View Tweet )

Best of 2024: BSR Guidelines for Systemic Sclerosis Management

The British Society for Rheumatology has updated its 2015 guidelines for the management of patients with systemic sclerosis (SSc) based on published evidence, systematic literature review and expert opinion.

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How do you manage skin in Sscl? -RNA pol III + high risk for skin progression. -Limited+ low risk + stable Sscl no need for immunesuppresors. -Look for EF in pts with generalized morphea. -Ttnt of skin depending on other organ involvements. -If no Raynaud’s/hands spared think of… https://t.co/DZzhShKzS8 https://t.co/J9Qg1Lk2Wl
Dr. John Cush @RheumNow( View Tweet )
Nailfold video-capillaroscopy (NVC) study of 76 dermatomyositis (DM) pts - 74% had anomalous NVC patterns (diminished density, abnl morphology). NVC abnl pts had more Raynaud's, and cluster 1 were more likely to develop ILD.https://t.co/AsZ9CU2TZU https://t.co/TP1TMqotqi
Dr. John Cush @RheumNow( View Tweet )

Bah Humbug Vitamin D (12.20.2024)

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Nailfold video-capillaroscopy (NVC) study of 76 dermatomyositis (DM) pts - 74% had anomalous NVC patterns (diminished density, abnl morphology). NVC abnl pts had more Raynaud's, and cluster 1 were more likely to develop ILD.https://t.co/OC7jNHdFMn https://t.co/cCCO70Xzoh
Dr. John Cush @RheumNow( View Tweet )
Challenge in Measuring Cutaneous Lupus Activity and Severity JAMA Dermatology features a discussion by Drs. McMichael and Frey on measuring lupus skin disease in clinical trials and practice using the validated Cutaneous Lupus Erythematosus Disease Area and Severity Index… https://t.co/qyZPDzUduO https://t.co/cCoc3sWCJy
Dr. John Cush @RheumNow( View Tweet )

ICYMI: Evaluation of Bimekizumab in PsA

Bimekizumab (BKZ) is a monoclonal IgG1 antibody that selectively inhibits interleukin (IL)‑17A and F. There have been more updates on the 2 year data on BKZ at #ACR24, and this is a summary of four studies being presented this year at ACR24.

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Challenge in Measuring Cutaneous Lupus Activity and Severity

JAMA Dermatology features a discussion by Drs. McMichael and Frey on measuring lupus skin disease in clinical trials and practice using the validated Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI).

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What Lies Beneath: Understanding Nailfold Capillaroscopy Capillaroscopy is a non-invasive imaging technique used for the in vivo assessment of the microcirculation. It can be performed using various optical instruments, but only the dermatoscope and videocapillaroscope have… https://t.co/JK9EvuxWEV https://t.co/77AcwfKIzE
Dr. John Cush @RheumNow( View Tweet )

Diagnostic Delays in PsA

Despite the remarkable expansion of the therapeutic armamentarium for psoriatic arthritis (PsA), the MONITOR-PsA study highlights a persistent and critical issue: delays in diagnosis. The study findings are stark, with about 25% of patients having erosions at diagnosis.

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💊Litifilimab- another new molecule for SLE Anti BDCA2 🎯 In cutaneous lupus👉 👉Decrease CLASI score 👉Decrease IFN induced MxA expression #ACR2024 #ACRAmbassador https://t.co/AeJOGhVXIR
Ritasman Baisya @RitasmanB( View Tweet )
🌟IgG4RD: Lessons from the first 20 years🌟by Prof John Stone ⭐️Lesson 1- IgG4RD is a variable vessel vasculitis ✨Can cause small vessel vasculitis of the skin ✨One of few vasculitis causing coronary arteritis in adults ⭐️Lesson 2- IgG4RD is more common and severe in males… https://t.co/PvFXyOl5bp https://t.co/hAMelBoZvB
Darpan Thakare @darpan06T( View Tweet )
The #scleroderma-like pattern on NVC is observed in pts with #dermatomyositis and MCTD It consists of a combination of giant capillaries, some microhemorrhages, severe capillary loss and angiogenesis @RheumNow #ACR24 @rheumarhyme https://t.co/WO9BOYn4ir
#Scleroderma #molecular #signatures in #skin predict long term outcomes 👇worst with inflammatory signature This may have clinical and trial applicability Nice work! Abst0711 #ACR24 @RheumNow @ACRheum https://t.co/3CFxu6bACu
Janet Pope @Janetbirdope( View Tweet )
Sullivan et al. Vasculitis in VEXAS. 81 patients. 27% vasculitis. Cutaneous SVV 20%, AAV 2.5%, cutaneous MVV 2.5%, LVV 2.5%. @RheumNow #ACR24 Abstr#2651 https://t.co/AV3RcuSKpV https://t.co/xrax025TzP
Richard Conway @RichardPAConway( View Tweet )
Disseminated acanthamoeba : pt with modular painful skin lesions on his palms and scalp— initially dx’d with a cutaneous vasculitis- he got worse with immunosuppression. Imaging and histology shown #ThievesMarket #ACR24 @RheumNow https://t.co/FjJ0Sk0Kxt
TheDaoIndex @KDAO2011( View Tweet )
Dr. CStone et al. assessed nailfold dermoscopy in distinguishing DM from SLE Almost all DM pts had nailfold changes in at least 1 digit vs. SLE & majority of DM pts had nailfold changes in all 10 digits Dermoscopy is a simple alternative to capillaroscopy @rheumNow #ACR24 ab2404 https://t.co/6tEXAlX7lt
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