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Dermatology

CRP and Hidradenitis Supprativa

A post hoc analysis of 2 phase 3 randomized clinical trials (PIONEER I and II)  of adalimumab vs Placebo in patients with active Hidradenitis suppurativa (HS) demonstrated more severe HS that was associated with elevated CRP had a higher BMI. Adalimumab was equally effective in patients

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Deucravacitinib in Psoriasis - 5 Year Outcomes

BMS released new five-year results from the POETYK PSO long-term extension (LTE) trial of deucravacitinib in treating patients with moderate-to-severe plaque psoriasis. The data was presented by Dr. Marc Lebwohl at the Winter Clinical Dermatology Conference in Hawaii

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TheDaoIndex @KDAO2011 80% #hydradenitis suppurativa pts are smokers or former smokers, smoking can predate #HS by 4-5 years. Other associations: DM-2, Spa, obesity, SAPHO, PCOS eval for SCC (squ. cell CA) #RNL2025 https://t.co/XHrFseiAMK
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Eric Dein @ericdeinmd How do you know if Morphea is active? -Erythema -Peripheral induration -New lesions in the past few month Non-active damage? - Dermal atrophy -SQ atrophy -Hyperpigmentation -Skin thickness center #RNL2025

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Eric Dein @ericdeinmd #RNL2025 Treatment of sclerosing skin conditions: Active inflammation? Sclerotic? Atrophic? Target based on activity, depth of involvement and other disease involvement

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Janet Pope @Janetbirdope #ClinicalPearl Insights into #fibrosing #skin conditions Inflammatory Fibrotic Atrophy We treat the #inflammation but need to determine if lesions are active or not Bx May not discern #dx Heidi Jacobe ⁦ #RNL2025 https://t.co/dG1k4fm4aO https://t.co/5TowCCDiTt
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Valentine RNL 2025 Review (2.14.2025)

Dr. Jack Cush reviews highlights from RheumNow Live 2025 held in Dallas, TX on Feb. 8-9, 2025.

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“Preventing” Arthritis in Psoriasis

The always compelling Dr. Alexis Ogdie explored whether aggressive treatment of psoriasis can prevent psoriatic arthritis in an excellent Saturday morning session at RheumNow Live 2025.

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MDA5 + Pts with #ILD in #dermatomyositis can improve! ⁦@RheumNow⁩ ⁦@ACRheum⁩ #RNL2025 Data from Christina Charles-Schoeman #ClinicalPearl Her pearls 👇 #DM is a #vascular #disease #CK is not reliable in chronic DM Neg Abs don’t r/o #myositis https://t.co/hxomz70aq5
Janet Pope @Janetbirdope( View Tweet )
#RNL2025 @RheumNow Dermatomyositis is VASCULAR disease -IVIG may help DM by blocking complement deposition on endomysial capillaries -CK levels not reliable Pruritus common in up to 86% of DM patients Dr. Charles-Schoeman, UCLA

Eric Dein @ericdeinmd( View Tweet )

Drug Naming Games (2.7.2025)

Dr. Jack Cush reviews the news, regulatory and journal reports from the past week on RheumNow.com.

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Cardiovascular Risk in Cutaneous Lupus Erythematosus

A retrospective study of cutaneous lupus erythematosus (CLE) patients finds an increased risk of atherosclerotic cardiovascular disease (ASCVD) on par with systemic lupus patients.

An IBM MarketScan Commercial Claims data analysis from 2018 to 2020 included

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Fallen Angels (1.17.2025)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com; and pays homage to colleagues who passed away in 2024.

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Childhood Maltreatment and the Risk of Rheumatic Diseases

EurekAlert!

A UK retrospective matched open cohort study shows that children who suffered frmo abuse, neglect or domestic abuse carry a significantly increased risk of developing rheumatoid arthritis or psoriasis in later life.    

Researchers used Dexter software and over 16 million

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Dazukibart Effective in Adults with Dermatomyositis

Lancet reports that the use of dazukibart, a selective monoclonal antibody against interferon B (IFNβ), was clinically effective in reducing disease activity in adults with active dermatomyositis (DM).

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Alive in 2025 (1.10.2025)

Dr. Jack Cush brings in the new year with a review of the latest from RheumNow.com

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Anti-Zoster Drug Prevents Shingles in Lupus Patients on Anifrolumab

MedPage Today

The antiviral drug valaciclovir (Valtrex), given prophylactically, kept patients with systemic lupus erythematosus (SLE) under treatment with anifrolumab (Saphnelo) from having herpes zoster attacks, researchers said, offering a potential alternative to zoster vaccination.

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Phase 3 Trial Results of Deucravacitinib in Psoriatic Arthritis

Bristol Myers Squibb announced recently the results from POETYK PsA-1 and POETYK PsA-2, Phase 3 trials pivotal trials of deucravacitinib (DEUC) in adults with active psoriatic arthritis. Both trials met their primary endpoint, demonstrating ACR20 efficacy after 16 weeks of treatment with DEUC

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JAK inhibitors are effective at repigmentation in vitiligo. 5 RCTs, 1,550 pts showed >50% improvement (TVASI50; RR 2.67) or >75% (FVASI75; RR 3.97_ JAKi increased skin AE, but not significantly different from placebo pts. https://t.co/zIreYlUyLt https://t.co/pCWKL2vSVs
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Best of 2024: BSR Guidelines for Systemic Sclerosis Management

The British Society for Rheumatology has updated its 2015 guidelines for the management of patients with systemic sclerosis (SSc) based on published evidence, systematic literature review and expert opinion.

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How do you manage skin in Sscl? -RNA pol III + high risk for skin progression. -Limited+ low risk + stable Sscl no need for immunesuppresors. -Look for EF in pts with generalized morphea. -Ttnt of skin depending on other organ involvements. -If no Raynaud’s/hands spared think of… https://t.co/DZzhShKzS8 https://t.co/J9Qg1Lk2Wl
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Nailfold video-capillaroscopy (NVC) study of 76 dermatomyositis (DM) pts - 74% had anomalous NVC patterns (diminished density, abnl morphology). NVC abnl pts had more Raynaud's, and cluster 1 were more likely to develop ILD.https://t.co/AsZ9CU2TZU https://t.co/TP1TMqotqi
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Bah Humbug Vitamin D (12.20.2024)

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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Nailfold video-capillaroscopy (NVC) study of 76 dermatomyositis (DM) pts - 74% had anomalous NVC patterns (diminished density, abnl morphology). NVC abnl pts had more Raynaud's, and cluster 1 were more likely to develop ILD.https://t.co/OC7jNHdFMn https://t.co/cCCO70Xzoh
Dr. John Cush @RheumNow( View Tweet )
Challenge in Measuring Cutaneous Lupus Activity and Severity JAMA Dermatology features a discussion by Drs. McMichael and Frey on measuring lupus skin disease in clinical trials and practice using the validated Cutaneous Lupus Erythematosus Disease Area and Severity Index… https://t.co/qyZPDzUduO https://t.co/cCoc3sWCJy
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