Skip to main content

Dermatology

Overview of New VEXAS Syndrome

Apr 08, 2021

Medscape offers up an informative overview of the newly described syndrome called VEXAS discovered by researchers at the National Institutes of Health. These patients were previously misdiagnosed with Sweets syndrome, relapsing polychondritis, myelodysplastic syndrome, MGUS, or polyarteritis

Read Article

Reactogenicity Following mRNA COVID-19 Vaccines

Apr 06, 2021

JAMA has published the real-world reporting of mRNA vaccine side effects (reactogenicity) gathered from CDC V-safe Surveillance system and shows that local and systemic reactions were often mild and transient and most commonly seen during the first day following their second dose.

Read Article

Rituximab in Systemic Sclerosis?

Apr 05, 2021

No drug is FDA approved to manage the skin or joint complaints of systemic sclerosis (SSc); a recent metanalysis suggests that rituximab may improve skin score and disease activity indices (DAS, mRSS) while stabilizing organ involvement in SSc patients.

Read Article

RheumNow Podcast – Upadacitinib Wins in PsA (4.2.2021)

Apr 02, 2021

Dr Jack Cush reviews the news and Journal reports and takes "Back Talk" questions from viewers.

Read Article

Upadacitinib Clinical Efficacy in Psoriatic Arthritis

Apr 01, 2021

McInnes and colleagues have published the results of the SELECT - PsA trial in NEJM showing updacitinib (UPA) to be superior to placebo in active psoriatic arthritis (PsA) patients, with 15 mg UPA equal to adalimumab (ADA) and 30 mg UPA qd being superior to ADA.



Janus kinase

Read Article

Psoriatic Disease Management - RNL 2021 Highlights

Mar 29, 2021

This year’s coverage of psoriatic arthritis was once again, both exciting and informative. Topics included an overview of the latest therapeutic options, an excellent discussion on psoriasis specifically, and the epidemiology of psoriatic arthritis. 

Read Article
Takeaways from #RNL2021 from Dr. Rachel Tate ( @uptoTate ) "Severe flares in PsO pts previously well controlled: look for infection (HIV or other) and/or underlying malignancy. Melodie Young, NP #RNL2021" #RheumNow

Dr. John Cush @RheumNow( View Tweet )

Mar 29, 2021

RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Mar 26, 2021

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.




  1. Analysis of CPRD registry and 15,670 MTX treated pts (46,571 PYs) showed discontinuation for abnormal or severely abnormal labs was 42/1000PY and 6/1,000PY and half that

Read Article

RheumNow Podcast – Great Associations (3.19.2021)

Mar 18, 2021

Dr. Jack Cush rants on the journal reports, news and FDA actions featured this past week on RheumNow.com.

Read Article

Apremilast Equals MTX in Palmoplantar Psoriasis

Mar 18, 2021

Palmoplantar psoriasis (PPP) is a therapeutically challenging variant of psoriasis; nonetheless, a prospective, randomized, active-controlled trial from India suggests that apremilast is effective and safe in patients with PPP.

Read Article

Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures

Mar 17, 2021

JAMA Dermatology has published a Danish national cohort study showing that potent topical corticosteroid use was associated with an increased risk of osteoporosis and major osteoporotic fractures with a dose-response association for cumulative use.



Clearly systemic and inhaled

Read Article

MDA-5 Antibodies and Juvenile Dermatomyositis

Mar 17, 2021

A multicentre, retrospective study examined MSA profiles (by immunoprecipitation) from 96 juvenile idiopathic inflammatory myopathies (JIIM) at nine pediatric rheumatology centres in Japan. MSA were found in 85 of 96 cases with over 90% of patients having one of the following three MSA types

Read Article

Enthesitis Responses to Secukinumab in Spondylitis Patients

Mar 16, 2021

Schett and colleagues studies the secukinumab (an IL-17 inhibitor) response in patients from 3 clinical trials with enthesitis and ankylosing spondylitis (AS) and demonstrated consistent efficacy with improved enthesitis scores at both peripheral and axial sites.



Pooled data from the

Read Article

RheumNow Podcast – Pounds of Prevention (3.5.2021)

Mar 04, 2021

Dr. Jack Cush reviews and discusses nearly a dozen news reports and journal articles from the past week on RheumNow.com.

Read Article
Report from DANBIO Danish register looked at chronic pain in a matched cohort study of Psoriasis. Chronic pain was not associated with excess mortality (hence not PsA) (OR 0.99,0.95-1.03). Mortality was increased with steriods, COPD, DM, CA, CV disease.  https://t.co/91JW3BOPtw

Dr. John Cush @RheumNow( View Tweet )

Mar 02, 2021

RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

Feb 26, 2021

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

Read Article
Psoriasis has greatest risk of MTX liver dz - a Danish Population study of PsO, PsA & RA pts taking MTX. Risk of liver Dz was most in PsO, followed by PsA, then RA. PsO had 1.6-3.4 fold risk (mild-severe) liver dz (vs RA). PsA was 1.3-1.6x higher) https://t.co/9YiGqVr66w

Dr. John Cush @RheumNow( View Tweet )

Feb 25, 2021

Lung Preservation with Tocilizumab in Early Systemic Sclerosis

Feb 21, 2021

Arthritis & Rheumatology has published the results of a subanalysis from tocilizumab (TCZ) clinical trials showing that Il-6 inhibition was associated with preservation of lung function patients with early systemic sclerosis (SSc).

Read Article
Dr. Shenoi Suspect autoinflammatory Dz: patterned fevers MSK and skin involvement Serositis Other - aphthous ulcers, CNS (stroke, basal ganglia calcification,) ILD, LN, lipodystrophy) ethnicity (FMF or Mediterranean) Family Hx -- Testing options! #RWCS2021 @RheumNow @RWCSmtg https://t.co/DZk4hsxbk4
Dr. Rachel Tate @uptoTate( View Tweet )
Feb 13, 2021
Dr. Phil Teh's #RWCS2021 poster: Wheal of Misfortune https://t.co/sGRPtjrSrl via @YouTube @RWCSmtg @rhemnow

Dr. Rachel Tate @uptoTate( View Tweet )

Feb 13, 2021

ACR Promotes New COVID-19 Vaccine Clinical Guidance for Rheumatic Patients

Feb 10, 2021

The American College of Rheumatology has published a draft guidance on the use of COVID-19 vaccination in rheumatic disease and musculoskeletal disease patients, based on the efforts of the North American Task force. The document provides guidance to rheumatology providers on the use of the

Read Article
Bimekizumab, a bispecific mAb inhibits IL-7F & IL-17A, was testedin PhIII trial in Active psoriasis and show to be more effective than ustekinumab and placebo. 567 PSO pts - at wk 16, PASI90 was BMKZ 85% vs Ustekinumab 50%, vs 5% in placeob (p<0·0001) https://t.co/Z4ZQEHO4rX

Dr. John Cush @RheumNow( View Tweet )

Feb 08, 2021
PSOLAR study of 298 pregnancies in 220 women with mod-severe psoriasis. 82% resulted in live births and rates of spontaneous abortion and congenital anomalies same as US population. Biologic exposure pregnancy outcomes same as those not on biologics https://t.co/GKXyDGRILD

Dr. John Cush @RheumNow( View Tweet )

Feb 05, 2021

Low Persistence of Biologics in Psoriatic Arthritis

Feb 02, 2021

A longitudinal observational cohort study of psoriatic arthritis (PsA) patients treated with biologic therapy finds relatively low persistence of selected biologic therapy in PsA patients



Analysis of PsA patients (n=2301) from a large healthcare provider database, seen between 2002

Read Article

RheumNow Podcast – Rheumatology Burnout (1.29.2021)

Jan 28, 2021

Dr. Jack Cush reviews this past week's journal articles and news features on RheumNow.com. Colchicine, vaccine rollout, risk of RA in endometriosis patients, tREACH trial, lupus nephritis news, rheumatology burnout and more.

Read Article
×