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Dermatology

2025 ACR Guideline for the Treatment of SLE

The ACR has released its 2025 Systemic Lupus Erythematosus (SLE) treatment guidelines and consensus-based good practice statements, applicable to children and adults with SLE. 

Overall, the goals of SLE management are to achieve remission or a low level disease activity, reduce

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Using publicly available FAERS safety data, drug-induced photosensitivity (DIP) - among 17+ million safety reports, there 20,236 linked to DIP. The most common wereimmunosuppressants, monoclonal Abs, neoplastic agents, including adalimumab, adapalene, secukinumab, fingolimod https://t.co/zA9UdYASKB
Dr. John Cush @RheumNow( View Tweet )
Lupus Clinical Slides: Set 1 https://t.co/zFQqHfl8Ch https://t.co/kvVNAS17ec
Dr. John Cush @RheumNow( View Tweet )
Lupus QD Clinic - Rhupus dsDNA+ SLE Plus CCP+ RA = Rhupus https://t.co/lyV7fgd1vp https://t.co/Ptw0dmyqCj
Dr. John Cush @RheumNow( View Tweet )
The ANA pattern I hate #DFS Why Dense fine speckled should R/O #SLE But mimicking patterns that MAY Have #lupus AC-2 pattern mimickers ex AC-4 Machine learning models to help ▶️improved accuracy Fast saving hrs #Artificial #intelligence May Choi #LUPUS2025 @RheumNow https://t.co/9tk80ZOAWg
Janet Pope @Janetbirdope( View Tweet )
Any ‘toll’ in #toll #like #receptors 7,8 in #SLE Cutaneous #lupus In #systemic or #cutaneous wk16 Rx PBO V #enpatoran No obvious dose response - all 3 dose >PBO Safe so far improves IFN No toll to pay! 👍 But need Ph3 data #LUPUS2025 @EricFMorand @RheumNow https://t.co/2DDztlVsUm
Janet Pope @Janetbirdope( View Tweet )
Vitiligo affects up to 2% of people globally; more in blacks & hispanics than whites & more common in women > men. The prevalence has increased over time. Oral corticosteroids are most frequently prescribed, followed by other immunosuppressive drugs https://t.co/wNh6z3lKg1 https://t.co/hQo9sNn4kg
Dr. John Cush @RheumNow( View Tweet )

Biologics in Pregnancy Patients With Autoimmune Disease

A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients than those with rheumatoid arthritis (RA), psoriasis (PsO) or psoriatic

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Panacea of Prednisone & Cannabis (5.16.2025)

Dr. Jack Cush reviews the news, journal and regulatory reports from this week on RheumNow.com.  Interesting trends and results with prednisone in lupus, cannabis in RA and opioid deaths too!

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J&J announced results of Phase 3 ICONIC-TOTAL study of qd icotrokinra, an oral IL-23 receptor inhibitor, in 311 ps w/ difficult scalp and genital psoriasis (PSO) -success in 57%; skin clearance in 66% & genital psoriasis resp in 77% treated https://t.co/WftyEcDh8u https://t.co/Ydy37Eo0jX
Dr. John Cush @RheumNow( View Tweet )
Full read overview of Discoid Lupus. https://t.co/G6lXWTRSFn https://t.co/yjVsDg0D5d
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TONIGHT! Tuesday Night Rheumatology: 🔓 Lupus Unlocked: Cutaneous SLE Join us for a discussion of the diagnosis, management, and latest insights into cutaneous manifestations of SLE. Featuring: Dr. Victoria P. Werth Dr. Matilda Nicholas Dr. Anthony Fernandez Dr. Christopher https://t.co/l0QjM9obk2
Dr. John Cush @RheumNow( View Tweet )
Full read overview of Discoid Lupus. https://t.co/aXgveR2NwF https://t.co/9JK6CNqedO
Dr. John Cush @RheumNow( View Tweet )
Tuesday Night Rheumatology: 🔓 Lupus Unlocked: Cutaneous SLE Join us for a discussion of the diagnosis, management, and latest insights into cutaneous manifestations of SLE. Featuring: Dr. Victoria P. Werth Dr. Matilda Nicholas Dr. Anthony Fernandez Dr. Christopher Richardson https://t.co/UNazbo9TuZ
Dr. John Cush @RheumNow( View Tweet )
Single-centre retrospective study, 27 children with refractory juvenile dermatomyositis (jDM) Rx with baricitinib (F/U of 25 mos)-- 77% (21/27) improved skin rashes (62% complete resolution) & Dz activity improved (6 vs 0.8, p<0.01) 70% (19/27) achieved inactive disease https://t.co/rRlhoY9O4q
Dr. John Cush @RheumNow( View Tweet )

Vitamin D Headlines (5.9.2025)

Dr. Jack Cush reviews the news, journal reports and lupus highlights from the past week on RheumNow.com. Triple positivity, the gut and CRPS, and hope for better outcomes with Vitamin D therapy. 

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Hyperpigmentation in SLE Young complex SLE patient develops blue-grey/slate colored hyperpigmentation on her arms and legs - From? Features Dr. Jack Cush https://t.co/yoKU7rJp8y https://t.co/Kh0tZLJ8SX
Dr. John Cush @RheumNow( View Tweet )
Tuesday Night Rheumatology: 🔓 Lupus Unlocked: Cutaneous SLE Join us for a discussion of the diagnosis, management, and latest insights into cutaneous manifestations of SLE. Featuring: Dr. Victoria P. Werth Dr. Matilda Nicholas Dr. Anthony Fernandez Dr. Christopher Richardson https://t.co/w7cYVNUI9t
Dr. John Cush @RheumNow( View Tweet )
An emulation trial shows that Humira biosimilars (Amjevita & Imraldi) were equivalent to Humira in psoriasis & achieving PASI <=2, both for new biologic starts and for biologic switchers. https://t.co/8lTGGs2rbP https://t.co/T6rTJ5ESj2
Dr. John Cush @RheumNow( View Tweet )
Bullhead Sign in #SAPHO Syndrome ▶️Synovitis, ▶️Acne ▶️Pustulosis ▶️Hyperostosis ▶️Osteitis 👉🏽https://t.co/ownI4Q543w via @MayoProceedings https://t.co/FXlTtmsDDX
Dr Ai Lyn Tan @DrAiLynTan( View Tweet )
✅ Management of #REFRACTORY skin manifestations in patients with #LUPUS ➡️ my practical tips 💪 for #PANLAR2025 🇲🇽 https://t.co/KnJO0eXI4W
Laurent ARNAUD @Lupusreference( View Tweet )
JAMA Pt Education handout - Scleroderma https://t.co/UpK24WfyNF

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Osteoarthritis Risky Business (4.18.2025)

Dr. Jack Cush reviews the news and Journal reports from this week on RheumNow.com.  Osteoarthritis patients have unique risks and synovial fluid WBC numbers can tell you when to worry about septic arthritis in gout and pseudogout patients.

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The Increasing Cost of First-Line Biologics for Plaque Psoriasis

A national commercial claims analysis of first-line use of biologics in biologic−naive plaque psoriasis patients found a near doubling of net treatment costs from 2007 to 2021 ($21 236 to $47 125). Despite the increasing costs, the 2021 average cost could have been 44% lower if the lowest-

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JAMA Pt Education handout - Scleroderma https://t.co/UpK24WfyNF

Dr. John Cush @RheumNow( View Tweet )

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