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FUTURE 2 Trial Shows Secukinumab to be Effective in Psoriatic Arthritis

Lancet today published the results of the phase 3, prospecitive, multinational, double-blind, randomized controlled trial of secukinumab (an anti-IL-17A monoclonal antibody) in active psoriatic arthritis.

Microscopic Polyangiitis Associated with Pulmonary Fibrosis

Microscopic polyangiitis (MPA) is one of several vasculitides that affects the lung.  Its most common pulmonary complication is diffuse alveolar haemorrhage, which carries a significant morbid risk.

Fresolimumab (anti-TGF beta) Improves Systemic Sclerosis

Transforming growth factor (TGF-β) is known to have potent profibrotic activity and has been implicated in the pathogenesis of systemic sclerosis a futile condition with no effective disease modifying treatments.

Management of Digital Ulcers in Scleroderma

Currently there are no FDA-approved medications for the treatment of digital ulcerations in the United States.  Digital ulcers are a common, unfortunate and difficult to manage consequence of the vascular obliteration and fibrosis that accompanies systemic sclerosis.

ACP Backs Supreme Court Decision on Obamacare

ACP has endorsed the Supreme Court ruling that the premium subsidies created by the Affordable Care Act, essential to making coverage affordable to millions, will continue to be available in states where the federal government manages their health insurance marketplaces.

Drug Shortages - June 2015

RheumNow is committed to reporting safety issues in our monthly Drug Safety Bulletins. Each month we will update you with reports of new, ongoing and resolved Drug Shortages that will affect the practicing rheumatologist.

Fibromyalgia Update: Genes, Hyperbaric Therapy & Conflicts of Interest

An Israeli crossover trial analyzed the efficacy of hyperbaric oxygen therapy (HBOT) in 60 patients with fibromyalgia.

IM Residents Concerned about Cost, But Don't Have Access to Cost of Care Numbers

A large ACP survey of over 18,000 US internal medicine residents shows they often incorporate cost of care in discussions and decisions, but may not know the data (citation source http://buff.ly/1KeLq0D).

Doctors are Unaware How Opioids are Abused

A survey of internists and family practitioners shows that half of physicians are unaware of how opioids are abused.

Adherence to Lupus Meds Linked to Increased Acute Hospitalizations

Using Medicaid data from 2000-2006, 9,600 hydroxychloroquine new users were compared to 3,829 new users of immunosuppressive agents (IS) in patients with SLE. They assessed adherence using the MPR - the medication possession ratio.

Adherence to ETN/MTX is Greater Than Triple DMARD Therapy

Rheumatoid management hinges on choosing your best therapies first.

Right Knee Pain - What's Your Dx?

A 36 year-old white male butcher has right knee pain for 3 weeks. He noted a similar episode 5 years earlier and admits to a traumatic fall on that knee years ago. He denies fever, redness, warmth, other joints or other past medical problems. He only takes OTC ibuprofen prn. 

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