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Cost Efficacy of Knee Replacement in Obese Osteoarthritis

Apr 05, 2021

Total knee replacement (TKR) in obese patients with end-stage knee osteoarthritis appears to be a beneficial and cost-effective strategy for treating. The only potential limitation is a greater risk for adverse events in those with a body mass index (BMI) of 40 kg/m2 or greater.

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Aortic Calcification and Lumbar Fracture Risk in Older Men

Mar 30, 2021

Fractures of the spine and abdominal aortic calcification (AAC) can both be visualized with spinal imaging; a new report shows that finding both radiographic vertebral fracture and AAC on the same lateral spine images may predict the risk of future incident major osteoporotic fracture in

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News Feature: FDA Panel Rejects Tanezumab for Osteoarthritis A 2 day FDA review by the Drug Safety and Risk Management and Arthritis Advisory Committees has yielded a 19-1 vote against the approval of tanezumab for use in OA. https://t.co/ltKmm9Nl1y https://t.co/qTWhSX9LBd
Dr. John Cush @RheumNow( View Tweet )
Mar 26, 2021

FDA Panel Rejects Tanezumab for Osteoarthritis

Mar 25, 2021

A two day FDA review by the Drug Safety and Risk Management and Arthritis Advisory Committees has yielded a 19-1 vote against the approval of tanezumab, a nerve growth factor inhibitor, for use in osteoarthritis (OA).



Tanezumab (TAN) has been developed by Pfizer and Eli Lilly over the

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News Feature: Are You a Super Rheum? https://t.co/LsGpFNXlkp https://t.co/Q9iojEQNqL
Dr. John Cush @RheumNow( View Tweet )
Mar 19, 2021
RCT shows Stepped Exercise Program to be effective in Knee Osteoarthritis. VAMC study of 345 knee OA pts given either STEP-KOA (internet based progr) or an arthritis education (control). WOMAC scores at 9 mos were 6.8 points lower in the STEP-KOA group.https://t.co/EuoPyJkTif

Dr. John Cush @RheumNow( View Tweet )

Mar 19, 2021

RheumNow Podcast – Great Associations (3.19.2021)

Mar 18, 2021

Dr. Jack Cush rants on the journal reports, news and FDA actions featured this past week on RheumNow.com.

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β-blockers may lower risk of knee OA and knee pain. Matched cohort study of 100K pts from UK registry shows β-blocker use associated with 10-12% lower risk of knee OA, knee pain & hip pain consultations, moreso w/ Propranolol and atenolol (9-22%) https://t.co/38RoeP1Pmw

Dr. John Cush @RheumNow( View Tweet )

Mar 16, 2021
Intraarticular Steroids in OA - They Dont work & Not Safe https://t.co/fB9SDFMVgf https://t.co/u14ibcRpvZ
Dr. John Cush @RheumNow( View Tweet )
Mar 15, 2021

RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

Feb 26, 2021

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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News Feature: Diagnosis & Treatment of Osteoarthritis Reviewed Katz, Arant and Loeser have published a comprehensive open-read overview of OA of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth https://t.co/VVnUk02KiP https://t.co/97dFC56Jcb
Dr. John Cush @RheumNow( View Tweet )
Feb 24, 2021

Diagnosis & Treatment of Osteoarthritis Reviewed

Feb 22, 2021

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth. 



OA affects an estimated more than 240 million people worldwide, and more

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Population based study of smoking cessation & risk of TKR in knee OA. TKR higher in recent quitters (26.7/1000PY vs 17.4/1000PY in smokers). adjusted HR=1.30 (95%CI:1.05-1.59). TKR risk was higher among quitters with weight gain (HR=1.42) https://t.co/6onQWQeFcI

Dr. John Cush @RheumNow( View Tweet )

Feb 22, 2021
SF analysis usually confirms dx, but changes dx 14%. 264 SF samples showed MSU crystals in 89% gout, 9% of CPPD pts. CPP crystals found in 54% of CPPD, 43% of OA & 7% of gout pts. Ca hydroxyapatite seen 1/3 RA, 1/2 OA & 2/3 CPPD https://t.co/B8UkHagXK3 https://t.co/UTncLo6Fyu
Dr. John Cush @RheumNow( View Tweet )
Feb 19, 2021
On March 24, 2021 the FDA Arthritis Advisory Committee and Drug Safety .... Committees will meet online to will discuss biologics license application, for tanezumab, from Pfizer, for the proposed treatment of moderate to severe osteoarthritis in adults https://t.co/NSlutqdHzu

Dr. John Cush @RheumNow( View Tweet )

Feb 18, 2021
RWCS Highlights - Day 4 from Dr. Rachel Tate ( @uptotate) -Novel Therapies Year in Review (RA, SLE, OA) -Novel concepts in Pediatric Rheumatology -TeleRheumatology Update: Post-COVID, Pre-?? https://t.co/JoTV25suxD https://t.co/Id19zgRT37
Dr. John Cush @RheumNow( View Tweet )
Feb 17, 2021

RWCS Highlights - Day 3

Feb 15, 2021

Day 3 report from the 2021 RWCS meeting in Maui (and virtually) includes pearls from the PsA 2020 Year in Review; fact vs. fiction on evidence based medicine: diet and rheumatic diseases; hot topics in allergy/immunology; and pediatric rheumatology highlights.

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NSAIDs in Osteoarthritis: Study Suggests Need for New Look Knee osteoarthritis (OA) patients using NSAIDs showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated. https://t.co/KNbAnNOkva https://t.co/s9mMmAR6TD
Dr. John Cush @RheumNow( View Tweet )
Feb 10, 2021

NSAIDs in Osteoarthritis: Study Suggests Need for New Look

Feb 08, 2021

Knee osteoarthritis (OA) patients using nonsteroidal anti-inflammatory drugs (NSAIDs) showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated.



Compared with current non-users of NSAIDs, those who were treated with these

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QD Clinic - Chronic Monarthritis Treatment Considerations on Chronic Monarthritis https://t.co/7VmH1skHhb

Dr. John Cush @RheumNow( View Tweet )

Feb 07, 2021
OpenSAFELY analysis shows that NSAIDs safe w/ COVID. Study 1: 1/2 million NSAID users vs ~2 mill non-users found no difference in COVID-19 death (HR 0.96); Study 2: 1.7 million RA/OA pts, 10% on NSAIDs had a lower risk of COVID-19 death (HR 0.78) https://t.co/1f3JBmaf2e

Dr. John Cush @RheumNow( View Tweet )

Feb 05, 2021
Download Available-- Osteoarthritis vs. Rheumatoid Arthritis https://t.co/qvVEcKqNAM

Dr. John Cush @RheumNow( View Tweet )

Feb 03, 2021

RheumNow Podcast – Don’t Hold the Benlysta, Take the Vaccine (1.22.2021)

Jan 22, 2021

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com, with more than a dozen items to discuss on this week's podcast.

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Denosumab inhibiting osteolysis? 22 pts undergoing revision THR surgery for osteolysis, 10 Rx w/ denosumab had 83% fewer osteoclasts @ osteolysis membrane–bone interface. Proof concept: DEN may have osteoclast effects at implant interface https://t.co/dJ06rk0SR3

Dr. John Cush @RheumNow( View Tweet )

Jan 21, 2021
Results from Cohort Hip & Cohort Knee study (early symptomatic hip OA pts) finds that 1/9 went on to receive hip replacement during the 10-year follow-up. Clinical hip and Xray (ROA) OA increased over 10 yrs - ROA 19% to 49%, and clinical hip OA 27% to 43% https://t.co/AJXlkAxZiF https://t.co/PSY4ueXOsC
Dr. John Cush @RheumNow( View Tweet )
Jan 20, 2021
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