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Disease Modification in Lupus and Lupus Nephritis: Modifying the Natural Course of the Disease

  • Sponsored by GSK US Medical Affairs
May 01, 2023 9:00 am

Disease Modifications

A definition for disease modification in lupus and lupus nephritis has recently been proposed in a paper by van Vollenhoven et al.1

In this infographic and interactive activity, learn about the outcomes that should be assessed to prevent organ damage, and potential detours to be aware of along a patient’s journey to disease modification.

Infographic: Disease Modification in Lupus

Lupus Infographic

New to the concept of disease modification? Learn how it could be used to help treat patients with lupus in your clinical practice.

View the infographic


Interactive Patient Journey: Disease Modification in Lupus Nephritis

Image of a game of a patient journey

Follow a patient with lupus nephritis through their disease modification journey.

Open the interactive patient journey




1van Vollenhoven R, et al. Lupus Sci Med. 2022; 9(1):e000634. 

Learn About Scientific Advances in Monitoring for Renal Damage Accrual in Lupus Nephritis


Complete renal response is a key outcome to monitor renal damage accrual in lupus nephritis,1 and is usually defined as proteinuria <0.5 g/24 hours.2 However, patients who have achieved this proteinuria goal often still have renal disease activity.2-4

This video and podcast presented by Dr. Michelle Petri, Professor of Medicine at the Hopkins Lupus Center, describes how estimated glomerular filtration rate (eGFR) slope may be a valid surrogate endpoint for monitoring renal damage accrual in lupus nephritis.5


This content is also available as a 10-minute podcast

Podcast: how does complete renal response correlate with renal damage accrual in lupus nephritis?

Listen to the podcast



  1. Fanouriakis A, et al. Ann Rheum Dis. 2020;79:713–23.
  2. Weeding E et al. Lupus Sci Med. 2022;9:e000684.
  3. Malvar A et al. Nephrol Dial Transplant. 2017;32:1338–44.
  4. De Rosa M et al. Kidney Int. 2018;94:788–94.
  5. Levey AS et al. Am J Kidney Dis. 2020;75(1):84–104.



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PSE-US-1796 | April 2023