OP/Bone

Sleep disturbance increases disability progression - Prospective cohort data from from 70K Nurses’ Health Study w/ 392 having MS, 7,302 DM, & 25K OA. Having Sleep apnea or disturbances signif incr disability in OA & DM (OR~1.4) as was excessive daytime sleepiness… https://t.co/5PP18gqDqi https://t.co/u1HFOstv8W
Dr. John Cush @RheumNow( View Tweet )
Knee,injection

Intraarticular Steroids in OA Lowers Need for Pain Meds

MedPage Today

Is it possible that intra-articular corticosteroid injections for osteoarthritis might affect the use of opioids?

British patients with osteoarthritis (OA) who received intra-articular corticosteroid injections had less usage of

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Schnitzler Syndrome: A Rare Autoinflammatory Disorder A credible, quick overview Chronic Urticaria Monoclonal Gammopathy ( Recurrent Fever Bone & Joint Pain Elevated CRP &ESR https://t.co/sQ22t8Z46m https://t.co/nJOVCghoFa

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Dr. John Cush @RheumNow( View Tweet )
Peking Univ long term F/U of Knee replacement (TKA) in 226 patients (246 knees) shows prosthesis survival rates of 93.6%, 92.4%, 89.8%, and 71.8% at 10, 15, 20, and 25 years post-TKA, respectively. 20yr function somewhat less than 10yr, but still much better than preop… https://t.co/gJbedIEr91 https://t.co/q799oV8TNm
Dr. John Cush @RheumNow( View Tweet )
JAMA Review on Dx & Rx of Monoclonal Gammopathy of Undetermined Significance. MGUS has NO Sxs or organ damage. MGUS & Dz associations (OP, Autoimmune) were likely overestimated; M protein testing should be done if malignancy or MGCS is suspected. Risk of progression to malignancy… https://t.co/Jikc5q3BJL https://t.co/hxhcD4bJ2X
Dr. John Cush @RheumNow( View Tweet )
Blood Flow Restriction to Reduce Pain in Knee OA A technique now widely used in sports medicine to speed recovery from leg injuries helped reduce symptoms and improve function in people with osteoarthritis (OA) of the knee, a randomized trial showed. https://t.co/IF1tkT5yvC https://t.co/0zQn8oBjeG

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Dr. John Cush @RheumNow( View Tweet )
FDA has sent a Drug Safety Letter to VETERINARIANS about the use of Librela (bedinvetmab) & reported adverse reactions, deaths and neurological problems (ataxia, seizures, paresis). Rx was approved 5/23 to treat pain from osteoarthritis in dogs. https://t.co/LIZ4ZzXtmk https://t.co/uOVc2xsD5g

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Dr. John Cush @RheumNow( View Tweet )
Screening for Osteoporosis to Prevent Fractures - USPSTF Recommendations The US Preventive Services Task Force (USPSTF) has done a systematic review on osteoporosis screening to prevent fractures and put forth its recent recommendations. These recommendations pertain to adults… https://t.co/u8LsIf453d https://t.co/I5DsQkkV2X
Dr. John Cush @RheumNow( View Tweet )
Screening for Osteoporosis to Prevent Fractures - USPSTF Recommendations The US Preventive Services Task Force (USPSTF) has done a systematic review on osteoporosis screening to prevent fractures and put forth its recent recommendations. These recommendations pertain to adults… https://t.co/gQ1vcpxih7 https://t.co/SQLJPALq3f
Dr. John Cush @RheumNow( View Tweet )
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Screening for Osteoporosis to Prevent Fractures - USPSTF Recommendations

Jack Cush, MD

The US Preventive Services Task Force (USPSTF) has done a systematic review on osteoporosis screening to prevent fractures and put forth its recent recommendations. These recommendations pertain to adults 40 years or older with no known diagnosis of osteoporosis or history of fragility

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GLP-1 Agonists Alleviate Knee Osteoarthritis In October, the NEJM published a randomized clinical trial demonstrating the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1ra) in patients with obesity and knee osteoarthritis. https://t.co/3ETmyFWpWY https://t.co/wn1QDwKi3R

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Dr. John Cush @RheumNow( View Tweet )
Study of 1032 adults > 50 yrs on dialysis compared denosumab vs or oral bisphosphonates. 3 yr results showed compared with oral bisphosphonates, denosumab lowered the risk for fractures by 45% and increased the risk for MACE by 36% https://t.co/aogIFBrccy https://t.co/cnlxt5OEjj

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Dr. John Cush @RheumNow( View Tweet )
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Alive in 2025 (1.10.2025)

Jack Cush, MD

Dr. Jack Cush brings in the new year with a review of the latest from RheumNow.com

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Study of 1032 adults > 50 yrs on dialysis compared denosumab vs or oral bisphosphonates. 3 yr results showed compared with oral bisphosphonates, denosumab lowered the risk for fractures by 45% and increased the risk for MACE by 36% https://t.co/evaTc8Ag5Y https://t.co/wps14UddgP

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Dr. John Cush @RheumNow( View Tweet )
Best of 2024: Mixed Long-term Effects of Calcium and Vitamin D in Postmenopausal Women https://t.co/RxI1zlZ9YR https://t.co/vhsLi6HQAS

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Dr. John Cush @RheumNow( View Tweet )
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Best of 2024: Mixed Long-term Effects of Calcium and Vitamin D in Postmenopausal Women

Jack Cush, MD

A follow-up analysis of a randomized clinical trial found that the use of calcium and vitamin D supplements among postmenopausal women was associated with decreased risk for cancer mortality, but increased risk for cardiovascular disease mortality. The analysis is published in Annals of

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Best of 2024: Consensus Statements on Vitamin D

Jack Cush, MD

The “Controversies in Vitamin D” International Conference has published their proceedings on vitamin D metabolism, assessment, actions, and supplementation. Interestingly, optimal levels of 25-hydroxy vitamin D (25(OH)D) are still being debated.

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Bah Humbug Vitamin D (12.20.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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U.S. Preventive Services Task Force (USPSTF) has recommended AGAINST use of vitamin D +/- Ca for the primary prevention of fractures (or falls) in postmenopausal women/men > 60 years of age. or older.https://t.co/1bUBqTVaX0 https://t.co/AXWxduVkOT

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Dr. John Cush @RheumNow( View Tweet )
What are the predictors of fracture in #SLE? 🦴Prednisone! Even at low doses ≤5mg 🦴Stroke 🦴Caucasian race 🦴Female 🦴Low BMD Try to avoid steroid use. If they are needed, IM triamcinolone or IVMP preferable to oral GC. Ab2679 #ACR24 @RheumNow

Mrinalini Dey @DrMiniDey( View Tweet )

Conaghan et al. LEVI-04, neurotrophin-3 inhibitor in knee OA. 518 patients. Significant improvements in WOMAC pain and function, and PGA. So sign of any increase in rapidly progressive OA (as with NGF inhibitors) @RheumNow #ACR24 Abstr#L15 https://t.co/qud4wTAikY https://t.co/0wjjG4U4bf

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Richard Conway @RichardPAConway( View Tweet )
How long is a long acting #intra-articular #steroid #injection in #knee #osteoarthritis? #IA steroids can be q3monthly #RCT of IA #fluticasone #propionate Was superior to #placebo Seemed to last approx 24 weeks ➡️ sub analysis in moderate pain, BMI<30 #ACR24 @RheumNow #2106 https://t.co/QBFCqXd1Q8

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Janet Pope @Janetbirdope( View Tweet )
#Artificial #Intelligence can detect #osteoporosis On #CXR To detect #thoracic #vertebral #fractures > 100000 #chest #radiographs - test and validation cohorts found + results on ROC Helpful -sometimes vertebral changes are Not read on CXRs #ACR24 @RheumNow @ACRheum #2116 https://t.co/NxEaH0AKJv

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Janet Pope @Janetbirdope( View Tweet )
#Publication #bias to Nth degree. >1/3 of registered #postmeno #osteoporosis trials are NOT #published 👇search of trials 673 published Vs 489 not published 890000 pts MOSTLY when performed in the USA No accountability for NOT publishing #ACRbest #ACR24 @RheumNow #2122 https://t.co/UyMMbHhvvV

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Janet Pope @Janetbirdope( View Tweet )
Ren et al. XG005, compound with NSAID and neuropathic like effects, in knee OA. At week 4 significant improvements in WOMAC pain, stiffness, function, and primary endpoint of walking pain @RheumNow #ACR24 Abstr#L08 https://t.co/gQDwAmzI4G https://t.co/b22XC7rXnE

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Richard Conway @RichardPAConway( View Tweet )

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PMR might be one of the most rewarding diagnoses to make in real practice: the patient comes to you in severe debilitating pain, and you prescribe steroids, giving them their lives back! As much as this impressive response makes your intervention appear almost magical, there is the often-forgotten story about the implications of such a diagnosis and treatment on patients' daily lives.  Read Post

ICYMI: Telemedicine Bloopers and Successes

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At my COVID home command center, I feel pretty prepared for everything. From here, I can run my practice, manage and home-school 3 children and keep the family afloat.  I have 2 computers: one for telemedicine/business meetings and one for e-learning lessons/school updates that teachers and school administrators email me throughout the day for my children.  As a no-nonsense, organized mom and doctor, I felt ready to handle any issues that would arise.  Read Post
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