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OP/Bone

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Fracture Risk with Osteoporosis Drug Holidays

Jan 17, 2022

While bisphosphonate drug holidays are recommended, there are few comparative studies. Annals of Internal Medicine describes a propensity matched comparison study of risedronate and alendronate, showing that, compared to alendronate, risedronate drug holidays were associated with a small

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Best of 2021: Jack of All Subspecialties

Dec 31, 2021

It's great to be a rheumatologist, but boy, it's getting harder and harder. You have to be a jack of all trades. You have to be good at cardiovascular disease, osteoporosis, vaccination, inflammatory bowel disease - it just never ends. This and more, as Dr. Cush summarizes more than a dozen

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Best of 2021: Tofacitinib Safety Concerns

Dec 29, 2021

Dr. Jack Cush reviews and discusses the news and journal reports from the past week on RheumNow.com.

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Best of 2021: EULAR Guidelines on Intraarticular Therapy

Dec 20, 2021

EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.



The

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NYC Hosp for Special Surgery is the 1st to use a "smart" knee arthroplasty - TKR with a smart sensor capable of monitoring steps, speed, range of motion & other knee functions fed back to the orthopedist = called Persona IQ, FDA authorized https://t.co/QR49JC7oCz

Dr. John Cush @RheumNow( View Tweet )

Dec 13, 2021
Geriatric Rheumatology:Improving care of aging patients Dr.Kathryn Dao ( @KDAO2011) moderates a panel w/ Drs.Una Makris, Katherine Wysham, Sebastian Sattui + Devyani Misra, as they discuss aspects of improving care of/outcomes for aging patients. #ACR21 https://t.co/lF3yUZBEkd https://t.co/hYufA8ptqj
Dr. John Cush @RheumNow( View Tweet )
Nov 19, 2021
Osteoporosis in PsA: Dr. Rachel Tate ( @uptoTate) discusses Abstract #1325, presented at the #ACR21 annual meeting.https://t.co/xnRkPnHeTr https://t.co/nE3ehhCB4j
Dr. John Cush @RheumNow( View Tweet )
Nov 18, 2021
Dr. Lane on Ca/Vitamin D in Osteoporosis ⭐️🎯serum vitamin D 25OH ~38 ⭐️Studies since 2008 Auckland Calcium trial DO NOT support incr CV risk with Ca supplementation ⭐️Ca calculator: https://t.co/PLPMfZdIwb⭐️No sig change in fracture risk with supp #ACR21 #ACRAmbassador https://t.co/KUa52vf4gT
Veena Katikineni @VeenaRheumMD( View Tweet )
Nov 09, 2021
Dr Adachi presents ⬆️BMD gain with denosumab than risedronate in RA. Non-significant reduction in fractures (very small numbers) Interesting, but need to see fracture benefit in larger study to justify dmab as first line Abstr#0445 #ACR21 @RheumNow https://t.co/GgaS9JZGzb
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
A meta-analysis of 5 cohort studies showed that PsA is significantly associated with vertebral fractures pooled OR 2.09 (95% CI, 1.11 – 3.96; I2 70%). The review was not suggestive of publication bias @RheumNow #ACR21 Abst#1304 https://t.co/rjC776FXUA https://t.co/QvMWxN6ZZ7
Dr. Antoni Chan @synovialjoints( View Tweet )
Nov 08, 2021
Meta-analysis shows increased risk of vertebral fracture in PsA, OR 2.09. Abstr#1304 #ACR21 @RheumNow https://t.co/kTrR7I3HA0
Richard Conway @RichardPAConway( View Tweet )
Nov 08, 2021
#ACR21 A#0563 - Is FRAX score applicable for RA? 10 yr Olmsted County epi study: Yes ▶️ 76 osteoporotic fxs in RA pts, FRAX predicted 67 fx (SIR 1.13, not signif) ▶️ 21 observed hip fx, FRAX predicted 23.3 (SIR 0.9) ⭐️ No differences by ages/sexhttps://t.co/vWy7EmseZp @Rheumnow https://t.co/8BlzgQYqaV
Nov 07, 2021
@jhrheumatology Dr. Petri at #ACR21 Great Debate. Safety issues with Voclosporin: 1) Nephrotoxicity 2) Infection 3) CV Risk Factors 4) Malignancy 5) Neurologic toxicity 6) Osteoporosis 7) Drug interactions 8) Deaths 9) Pregnancy contraindication @RheumNow https://t.co/wjluivmKNt
Nov 06, 2021
While psoriasis and Psoriatic arthritis patients have an increased risk of fractures, there is no increased risk of osteoporosis or osteopenia. Data from 12 studies an 199 million individuals https://t.co/G4Ya7CUWYX

Dr. John Cush @RheumNow( View Tweet )

Oct 27, 2021
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Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis

Oct 27, 2021

A controlled trial of intra-articular platelet-rich plasma (PRP) injections into the ankle of osteoarthritis (OA) patients failed to improve ankle symptoms and function when compared to placebo injections - yet another trial showing that intraarticular injections are seldom beneficial.

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Pfizer/Lilly Pull Tanezumab Development

Oct 26, 2021

Today, Lilly and Pfizer announced their global clinical development of the NGF inhibitor, tanezumab, has been discontinued due to recent negative opinions from the EMA and FDA advisory committee.



This decision mirrors that of other companies (AbbVie, AstraZeneca, Johnson & Johnson

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ATOM study - Phase 3 RCT testing abaloparatide (Tymlos) in 228 men with osteoporosis. At 12 mos Tymlos shows signif increase in lumbar BMD of 1.2%. Also increased were hip and femoral neck BMD at 12 months. https://t.co/WC3ygkyMZH

Dr. John Cush @RheumNow( View Tweet )

Oct 25, 2021
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Are You a High or Low Glucocorticoid Prescriber?

Oct 15, 2021

A recent analysis shows thta glucocorticoids (GCs), usually recommended for short-term use in rheumatoid arthritis (RA), are variably used by rheumatologists, and that provider preference is a strong predictors of long-term glucocorticoid use.

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RheumNow Podcast – #ACA: Ask Cush Anything (10.8.2021)

Oct 08, 2021

Arthritis numbers are rising, and people are finally talking about osteoarthritis. Also, ACR 2021 is just a few weeks away - are you ready? Finally, I'll review cases and questions submitted by viewers in Ask Cush Anything (#ACA). This, and nearly a dozen news items and reports, are discussed in

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Prevalence of Arthritis Rising in the USA

MMWR
Oct 07, 2021

The latest CDC estimates of the national prevalence of arthritis and arthritis-attributable activity limitations (AAAL) show a continued increase in absolute number: 58.5 million (23.7%) U.S. adults have arthritis, 25.7 million (43.9%) of whom have AAAL. 

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Hip fractures represent a major global public health problem - data from ASBMR meeting suggests this is from an aging population and suboptimal OP treatment. Global study shows incr # hip fractures per year, but Post-fracture Rx only at 11-50% https://t.co/LlMDTrH93E https://t.co/ucrPzcnLZh
Dr. John Cush @RheumNow( View Tweet )
Oct 07, 2021
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Erosive Hand Osteoarthritis Portends Worse OA

Oct 06, 2021

An erosive hand osteoarthritis (EOA) study from the Osteoarthritis Initiative shows that EOA is more common in older women and is strongly linked to further progressive, articular structural damage.

This was a longitudinal cohort study of 3,365 individuals without prevalent erosive hand OA at

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AAOS Clinical Practice Guideline for Knee Osteoarthritis

Oct 04, 2021

The American Academy of Orthopaedic Surgeons has published their Clinical Practice Guideline for Management of Osteoarthritis of the Knee (Non-Arthroplasty); updating 19 of the 29 evidence-based recommendations and focuses on nonsurgical treatmentss to provide pain and patient function.

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RheumNow Podcast – Jack of All Subspecialties (10.1.2021)

Oct 01, 2021

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com




  1. A population based Swedish study of birth records shows that antibiotic exposure in first three years of life to be associated with a future risk of JIA, although infections during fetal

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PROCEED study of 300 pts with chronic, DXA proven bone loss in half (osteopenia in 39% and osteoporosis in 17%) with higher fracture rates. Such pts should undergo screening for osteoporosis. https://t.co/7fgeAk85vu

Dr. John Cush @RheumNow( View Tweet )

Sep 30, 2021
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