OP/Bone

Blood Flow Restriction to Reduce Pain in Knee OA A technique now widely used in sports medicine to speed recovery from leg injuries helped reduce symptoms and improve function in people with osteoarthritis (OA) of the knee, a randomized trial showed. https://t.co/IF1tkT5yvC https://t.co/0zQn8oBjeG

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Dr. John Cush @RheumNow( View Tweet )
FDA has sent a Drug Safety Letter to VETERINARIANS about the use of Librela (bedinvetmab) & reported adverse reactions, deaths and neurological problems (ataxia, seizures, paresis). Rx was approved 5/23 to treat pain from osteoarthritis in dogs. https://t.co/LIZ4ZzXtmk https://t.co/uOVc2xsD5g

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Dr. John Cush @RheumNow( View Tweet )
Screening for Osteoporosis to Prevent Fractures - USPSTF Recommendations The US Preventive Services Task Force (USPSTF) has done a systematic review on osteoporosis screening to prevent fractures and put forth its recent recommendations. These recommendations pertain to adults… https://t.co/u8LsIf453d https://t.co/I5DsQkkV2X
Dr. John Cush @RheumNow( View Tweet )
Screening for Osteoporosis to Prevent Fractures - USPSTF Recommendations The US Preventive Services Task Force (USPSTF) has done a systematic review on osteoporosis screening to prevent fractures and put forth its recent recommendations. These recommendations pertain to adults… https://t.co/gQ1vcpxih7 https://t.co/SQLJPALq3f
Dr. John Cush @RheumNow( View Tweet )
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Screening for Osteoporosis to Prevent Fractures - USPSTF Recommendations

Jack Cush, MD

The US Preventive Services Task Force (USPSTF) has done a systematic review on osteoporosis screening to prevent fractures and put forth its recent recommendations. These recommendations pertain to adults 40 years or older with no known diagnosis of osteoporosis or history of fragility

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GLP-1 Agonists Alleviate Knee Osteoarthritis In October, the NEJM published a randomized clinical trial demonstrating the efficacy of glucagon-like peptide-1 receptor agonists (GLP-1ra) in patients with obesity and knee osteoarthritis. https://t.co/3ETmyFWpWY https://t.co/wn1QDwKi3R

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Dr. John Cush @RheumNow( View Tweet )
Study of 1032 adults > 50 yrs on dialysis compared denosumab vs or oral bisphosphonates. 3 yr results showed compared with oral bisphosphonates, denosumab lowered the risk for fractures by 45% and increased the risk for MACE by 36% https://t.co/aogIFBrccy https://t.co/cnlxt5OEjj

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Dr. John Cush @RheumNow( View Tweet )
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Alive in 2025 (1.10.2025)

Jack Cush, MD

Dr. Jack Cush brings in the new year with a review of the latest from RheumNow.com

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Study of 1032 adults > 50 yrs on dialysis compared denosumab vs or oral bisphosphonates. 3 yr results showed compared with oral bisphosphonates, denosumab lowered the risk for fractures by 45% and increased the risk for MACE by 36% https://t.co/evaTc8Ag5Y https://t.co/wps14UddgP

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Dr. John Cush @RheumNow( View Tweet )
Best of 2024: Mixed Long-term Effects of Calcium and Vitamin D in Postmenopausal Women https://t.co/RxI1zlZ9YR https://t.co/vhsLi6HQAS

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Dr. John Cush @RheumNow( View Tweet )
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Best of 2024: Mixed Long-term Effects of Calcium and Vitamin D in Postmenopausal Women

Jack Cush, MD

A follow-up analysis of a randomized clinical trial found that the use of calcium and vitamin D supplements among postmenopausal women was associated with decreased risk for cancer mortality, but increased risk for cardiovascular disease mortality. The analysis is published in Annals of

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Best of 2024: Consensus Statements on Vitamin D

Jack Cush, MD

The “Controversies in Vitamin D” International Conference has published their proceedings on vitamin D metabolism, assessment, actions, and supplementation. Interestingly, optimal levels of 25-hydroxy vitamin D (25(OH)D) are still being debated.

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Bah Humbug Vitamin D (12.20.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

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U.S. Preventive Services Task Force (USPSTF) has recommended AGAINST use of vitamin D +/- Ca for the primary prevention of fractures (or falls) in postmenopausal women/men > 60 years of age. or older.https://t.co/1bUBqTVaX0 https://t.co/AXWxduVkOT

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Dr. John Cush @RheumNow( View Tweet )
What are the predictors of fracture in #SLE? 🦴Prednisone! Even at low doses ≤5mg 🦴Stroke 🦴Caucasian race 🦴Female 🦴Low BMD Try to avoid steroid use. If they are needed, IM triamcinolone or IVMP preferable to oral GC. Ab2679 #ACR24 @RheumNow

Mrinalini Dey @DrMiniDey( View Tweet )

Conaghan et al. LEVI-04, neurotrophin-3 inhibitor in knee OA. 518 patients. Significant improvements in WOMAC pain and function, and PGA. So sign of any increase in rapidly progressive OA (as with NGF inhibitors) @RheumNow #ACR24 Abstr#L15 https://t.co/qud4wTAikY https://t.co/0wjjG4U4bf

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Richard Conway @RichardPAConway( View Tweet )
How long is a long acting #intra-articular #steroid #injection in #knee #osteoarthritis? #IA steroids can be q3monthly #RCT of IA #fluticasone #propionate Was superior to #placebo Seemed to last approx 24 weeks ➡️ sub analysis in moderate pain, BMI<30 #ACR24 @RheumNow #2106 https://t.co/QBFCqXd1Q8

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Janet Pope @Janetbirdope( View Tweet )
#Artificial #Intelligence can detect #osteoporosis On #CXR To detect #thoracic #vertebral #fractures > 100000 #chest #radiographs - test and validation cohorts found + results on ROC Helpful -sometimes vertebral changes are Not read on CXRs #ACR24 @RheumNow @ACRheum #2116 https://t.co/NxEaH0AKJv

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Janet Pope @Janetbirdope( View Tweet )
#Publication #bias to Nth degree. >1/3 of registered #postmeno #osteoporosis trials are NOT #published 👇search of trials 673 published Vs 489 not published 890000 pts MOSTLY when performed in the USA No accountability for NOT publishing #ACRbest #ACR24 @RheumNow #2122 https://t.co/UyMMbHhvvV

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Janet Pope @Janetbirdope( View Tweet )
Ren et al. XG005, compound with NSAID and neuropathic like effects, in knee OA. At week 4 significant improvements in WOMAC pain, stiffness, function, and primary endpoint of walking pain @RheumNow #ACR24 Abstr#L08 https://t.co/gQDwAmzI4G https://t.co/b22XC7rXnE

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Richard Conway @RichardPAConway( View Tweet )
RA patients affected by frailty at a younger age in @VARA frailty associated with lower BMD But frailty is modifiable! #GeriRheum #ACR24 @RheumNow ABST#2140 https://t.co/BoTGoESB43

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Jiha Lee @JihaRheum( View Tweet )
A#2528 Hes1/Piezo1 Pathway - role in osteocyte response to mechanical stimulus Yoda1 - Piezo1 agonist shown to help fx healing in mice Piezo1 decrease in GIOP Basic sci research shows activation of pathway promotes mechanical stress response, decr GIOP #ACR24 @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Does adding a Clofutriben (HSD-1 inhibitor) w/ prednisone minimize the risks of steroid toxicities in #PMR patients? VS placebo, PMR patients who received Clofutriben + Prednisone had substantial reductions in bone, lipid, and glycemic control parameters @RheumNow #ACR24

Akhil Sood MD @AkhilSoodMD( View Tweet )

The precise mechanism of action of GIOP is not known. Decrease in osteocyte LCN is observed. Abstr#2528 @RheumNow #ACR24 https://t.co/fazUUy03fQ

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Antoni Chan MD (Prof) @synovialjoints( View Tweet )

📢Late-breaking #2003 🔑 Cappelli et al @jhrheumatology finds hip OA is NOT a significant risk factor for #ICI-IA 🔴#ICI-IA linked to lower mortality #ACR24 #ACRBest @RheumNow

Caoilfhionn Connolly @CaoilfhionnMD( View Tweet )

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