Pollution and Autoimmunity (7.12.2024)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.
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RT @drminidey
OP0165- incidence & risk factors of D2T RA in an early RA cohort
Factors assoc with D2T RA:
🩸 Seropositivity
🦴 Erosions
📈 Disease activity
📊 D2T pts have higher steroid doses & more commonly develop iatrogenic-related #comorbidities, e.g. osteoporosis
Dr. John Cush @RheumNow( View Tweet )
ICYMI: 2023 EULAR Non-pharmacological Management of Hip and Knee Osteoarthritis: 2023 update
EULAR has published the 2023 updated recommendations for the optimal non-pharmacological management of hip and knee osteoarthritis (OA).
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Late “Breaking”: Reducing Osteoporotic Fractures in Postmenopausal Women
Dr. Janet Pope discusses abstract POS0583 presented at Eular 2024 in Vienna, Austria.
https://t.co/HIXV4EUkJb https://t.co/p38e6pzAvC
Dr. John Cush @RheumNow( View Tweet )
When would I use
#Aclasta vs #Prolia since #denosumab has LESS #fractures
▶️younger women with #osteoporosis requiring Rx due to long safety
▶️less wearing off when stopping it
▶️noncompliant Pts as prolia reverses effect when dose is missed
@RheumNow #EULAR2024 @eular_org https://t.co/0RTGx0sCTd
Janet Pope @Janetbirdope( View Tweet )
What is better for #Rx of
#osteoporosis?
#Denosumab or ##Zoledronic acid?
#Prolia compared to #Aclasta
Giant admin US data of 125,000 Rx niaive women with #OP
▶️Prolia has LESS fractures!
POS0583 #EULAR2024 @eular_org @RheumNow https://t.co/eo1ny2VIRf
Links:
Janet Pope @Janetbirdope( View Tweet )
Check point inhibitors may cause bone loss and fractures. Lems W #EULAR2024 @RheumNow https://t.co/rf1AU60Eah
Dr. Antoni Chan @synovialjoints( View Tweet )
Can we withdraw treatment in post-menopausal osteoporosis?
EurekAlert!
Analysis of French claims data, found over half of women initiating oral bisphosphonates (BP) between 2015 and 2020 discontinued treatment for at least one year, which was associated with a 12% increase in fracture risk. While not recommended, 42.5% of women initiating Dmab discontinued
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OP0165- incidence & risk factors of D2T RA in an early RA cohort
Factors assoc with D2T RA:
🩸 Seropositivity
🦴 Erosions
📈 Disease activity
📊 D2T pts have higher steroid doses & more commonly develop iatrogenic-related #comorbidities, e.g. osteoporosis
#EULAR24 @RheumNow
Mrinalini Dey @DrMiniDey( View Tweet )
2023 EULAR classification criteria for hand osteoarthritis
A EULAR consensus group has established classification criteria for overall hand osteoarthritis (OA) and its subtypes (interphalangeal OA and thumb base OA).
The criteria require two mandatory criteria to be met:
must have
The ability to predict hip fractures just went to a new level
https://t.co/k9cAPIJigd
A proteomic risk score was found to be strongly predictive of incident hip fractures in multiple independent populations
@NatureAging https://t.co/WZemPZqsev
Links:
Eric Topol @EricTopol( View Tweet )
The Window of Opportunity (5.24.2024)
Dr. Jack Cush reviews the journal reports and news from the past week on RheumNow.com. This week: blockbuster drugs, opioids in rheumatology and nontreatment of inflammatory arthritis?
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Lille Univ Hosp study of 485 systemic sclerosis pts, found osteoporosis in 23% (18% w/ fragility Fx). OP independently linked to age (OR1.06), topoisomerase I Ab+ positivity (OR 2.22) & GC treatment (OR 4.48) https://t.co/9KN5VQnl4A https://t.co/L7RwDdzaFZ
Dr. John Cush @RheumNow( View Tweet )
Legal (Not So) Merry-Go-Round of Alendronate Atypical Fractures
Dr. Gregory Curfman, MD writes on the chronological legal progress of a lawsuit stemming from rare instances of atypical femoral fractures associated with bisphosphonate (alendronate) use.
https://t.co/6Ipvw7tcKr https://t.co/VNrMg88AsH
Dr. John Cush @RheumNow( View Tweet )
Legal (Not So) Merry-Go-Round of Alendronate Atypical Fractures
Dr. Gregory Curfman, MD (Executive editor of JAMA) writes on the chronological legal progress of a lawsuit stemming from rare instances of atypical femoral fractures associated with bisphosphonate (alendronate) use. While alendronate was FDA approved in 1995 for the prevention and
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Antacids can Diminish Bone Density
EurekAlert!
Proton pump inhibitors (PPIs), a specific class of antacid drugs, are among the most widely used medications of all. They are frequently prescribed to many groups of patients, including those with rheumatism. PPIs are used to prevent the stomach problems that can arise from taking certain
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Consensus Statements on Vitamin D
The “Controversies in Vitamin D” International Conference has published their proceedings on vitamin D metabolism, assessment, actions, and supplementation. Interestingly, optimal levels of 25-hydroxy vitamin D (25(OH)D) are still being debated.
Varying recommendations by society
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RECIPE Study: Non-opioid Analgesics following Total Hip Arthroplasty
Patients undergoing total hip arthroplasty using a combo of paracetamol, ibuprofen, + dexamethasone, had optimal responses with the lowest morphine consumption, & fewer adverse events.
https://t.co/PXmPGscwu3 https://t.co/2Lse0gNx70
Dr. John Cush @RheumNow( View Tweet )
Does Good Sleep Prevent Osteoporosis?
https://t.co/hA9O1UIItx https://t.co/SoEX6p4xNH
Dr. John Cush @RheumNow( View Tweet )
Does Good Sleep Prevent Osteoporosis
EurekAlert!
As part of the University of Colorado Department of Medicine’s annual Research Day, held on April 23, faculty member Christine Swanson, MD, MCR, described her National Institutes of Health-funded clinical research on whether adequate sleep can help prevent osteoporosis.
“Osteoporosis
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Lower Limb Muscle Mass Influences Osteoarthritis Risk
The Rotterdam study shows that weight-bearing recreational physical activity caused more incident knee osteoarthritis (KOA), but mainly when there was low muscle mass. KOA risk is traditionally linked to either obesity or injury. This study assesses whether muscle mass may influence
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Biomarker Predictors of Osteoarthritis
Science Advances has reported that Duke University researchers have validated a biomarkers of osteoarthritis that may be identified 2 years before the appearance of radiographic OA. Six peptides (biomarker) demonstrated an AUC 77% probability of successfully predicting knee
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Rheum Chapter Notes (4.26.2024)
Dr. Jack Cush reviews this past week’s news and journal articles from RheumNow.com.
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Prospective look at 25 280 older adults (mean 74yrs) w/ incident fracture, shows impact of multimorbidity by Charlson Comorbid Index (CCI). If CCI =2-3, Incr risk of subseq Fx (16-25%) & death (HR ~2); If CCI=4+, Fx Risk ^33-48%, death HR~4. https://t.co/6wnhFNiSXH https://t.co/Xy2y0ANDRd
Dr. John Cush @RheumNow( View Tweet )
Prevalence of MSK presentations in practice = 21.1%, based on UK practice cohort. Most common: pain in LS spine (18%) & knee (17%). Re-presentations of existing Dx made up 74% all MSK consultations. Steroid injx given to 1/3 of knee consults https://t.co/nTioq1lCEB https://t.co/ecm8Kxz2cu
Dr. John Cush @RheumNow( View Tweet )
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