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OP/Bone

Knee Replacement in Obese OA is Cost Effective

Jun 24, 2021

Debates over ideal candidates for total knee replacement (TKR) in osteoarthritis patients often excludes those who are obese, but a recent article in the Annals of Internal Medicine suggests that TKR is both effective and cost-effective in obese patients (BMI >40 kg/m2)

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How many of your postmenopausal RA ♀️ patients are on osteoporotic treatment? #EULAR2021 POS0164 ⭐️28% had prior fragility FX ⭐️50.5% at very high or high risk of fx according to FRAX 10 yr major fx risk Over 1/2 of patients at risk & indicated for treatment! @RheumNow

Eric Dein @ejdein1( View Tweet )

Jun 04, 2021

EULAR Guidelines on Intraarticular Therapy

May 26, 2021

EULAR has published evidence-based recommendations on the use of intra-articular therapies (IAT) based on the literature review and recommendations of a multidisciplinary international task force. These IAT recommendations apply to adult patients with peripheral arthropathies.



The

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Total Ankle Arthroplasty vs. Arthodeisis?

May 19, 2021

 The Journal of Bone & Joint Surgery reports the findings of a 4-year trial comparing outcomes of total ankle arthroplasty (TAA) versus ankle arthrodesis (AA) in patients with severe ankle arthritis; finding that while both groups improved, TAA was associated with less pain and better

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Severity Associated with Erosive Hand Osteoarthritis

May 18, 2021

Erosive hand osteoarthritis (EHOA) was studied as part of the Osteoarthritis Initiative, and shown to increase with advanced age and female sex, with developmental findings to suggest that EHOA as a disorder of skeletal frailty.



The Osteoarthritis Initiative is a longitudinal study of

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Little Effect with Multimodal Treatment of CMC1 Osteoarthritis

Apr 26, 2021

A randomized clinical trial of patients with CMC1 osteoarthritis shows modest benefits when a combination of conservative treatments (education, splinting, hand exercises, 1% diclofenac sodium gel) was used compared to education alone. While there were small to medium benefits with regard to

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Clinical pearl: Bisphosphonates can cause posterior iritis (consider this in patients with negative labs and long term use of bisphosphonates.) Dr. Wang #RNL2021 @RheumNow

Dr. Rachel Tate @uptoTate( View Tweet )

Apr 24, 2021

RheumNow Podcast – Coconspirators: RA and Lung Disease

Apr 23, 2021

Dr. Jack Cush reviews and discusses more than a dozen news and journal articles from the past week on RheumNow.com.

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RheumNow Podcast – Combination Biologics

Apr 16, 2021

Dr. Jack Cush serves up this week's news and articles from RheumNow.com.

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USPSTF - No Need to Screen for Vitamin D Deficiency

Apr 14, 2021

JAMA has published the new recommendation from the US Preventive Services Task Force (USPSTF) stating that screening for vitamin D deficiency is unnecessary and unwarranted in asymptomatic adults.

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NICE Guidelines on Chronic Pain Management

Apr 14, 2021

In the United Kingdom, where it is estimated that chronic pain affects one‑third to one‑half of the population, NICE (National Institute for Health and Care Excellence) has recently released an updated guideline on the management of chronic pain for people aged 16 years and over. This

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GLP-1 Therapy in Knee Osteoarthritis

Apr 08, 2021

Knee osteoarthritis is best managed by weight loss, as the effects of most analgesic therapies have been marginal and debatable. The use of anti-diabetic glucagon-like peptide-1 therapies have demonstrated significant weight loss benefits; hence this trial evaluated the potential weight loss and

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Can Targeting RANKL in RA Heal Erosions?

MedPage Today
Apr 07, 2021

Treatment with denosumab (Prolia) helped heal bone erosions over 2 years among patients with rheumatoid arthritis whose disease activity was well controlled, researchers reported.

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News Feature: Aortic Calcification and Lumbar Fracture Risk in Older Men https://t.co/6gcoP9EFey #RheumNow https://t.co/BTTrYAoyNp
Dr. John Cush @RheumNow( View Tweet )
Apr 02, 2021

Aortic Calcification and Lumbar Fracture Risk in Older Men

Mar 30, 2021

Fractures of the spine and abdominal aortic calcification (AAC) can both be visualized with spinal imaging; a new report shows that finding both radiographic vertebral fracture and AAC on the same lateral spine images may predict the risk of future incident major osteoporotic fracture in

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Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/OHohMKveik

Dr. John Cush @RheumNow( View Tweet )

Mar 28, 2021

RheumNow Podcast – Infection in ANCA-Associated Vasculitis (3.26.2021)

Mar 26, 2021

Dr. Jack Cush reviews the news, FDA Denials and journal articles from the past week on RheumNow.com.




  1. Analysis of CPRD registry and 15,670 MTX treated pts (46,571 PYs) showed discontinuation for abnormal or severely abnormal labs was 42/1000PY and 6/1,000PY and half that

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Using both glucocorticoids & PPI leads to additive risk of osteoporotic fractures - UK database studiedd 12351 RA pts - 1411 w/ OP Fx. Concomitant GCs + PPIs assoc w/ 1.6-fold risk of OP Fx (adj HR: 1.60) vs nonuse; more than 1.2-fold risk w/ either alone https://t.co/vvA6P5LEgs

Dr. John Cush @RheumNow( View Tweet )

Mar 22, 2021
News Feature: Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures https://t.co/KazNPRXKNx https://t.co/pykBdbexzF
Dr. John Cush @RheumNow( View Tweet )
Mar 20, 2021

Potent Topical Corticosteroids and the Risk of Osteoporotic Fractures

Mar 17, 2021

JAMA Dermatology has published a Danish national cohort study showing that potent topical corticosteroid use was associated with an increased risk of osteoporosis and major osteoporotic fractures with a dose-response association for cumulative use.



Clearly systemic and inhaled

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RheumNow Podcast – Sweet Lies or Hard Truths? (2.26.2021)

Feb 26, 2021

Dr. Jack Cush reviews and discusses the news and Journal reports from the past week on RheumNow.com.

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Diagnosis & Treatment of Osteoarthritis Reviewed

Feb 22, 2021

Katz, Arant and Loeser have published a comprehensive open-read overview of osteoarthritis (OA) of the hip and knee in JAMA; underscoring the impact, advances, disappointments and guidelines put forth. 



OA affects an estimated more than 240 million people worldwide, and more

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RWCS Highlights - Day 2 by Dr. Rachel Tate ( @uptotate) -What’s new in Spondyloarthritis -Osteoporosis and Beyond -Immunologic basis and clinical characteristics https://t.co/q4lI2BYhfz https://t.co/Q79CHaQrHf
Dr. John Cush @RheumNow( View Tweet )
Feb 15, 2021

NSAIDs in Osteoarthritis: Study Suggests Need for New Look

Feb 08, 2021

Knee osteoarthritis (OA) patients using nonsteroidal anti-inflammatory drugs (NSAIDs) showed greater loss of medial minimum joint space width than did others taking other drugs, registry data indicated.



Compared with current non-users of NSAIDs, those who were treated with these

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Abrupt Cessation of Long-Term Opioid Prescribing Common

MedPage Today
Feb 05, 2021

Medicare beneficiaries were increasingly likely to have long-term opioid therapy stopped in recent years and medication changes often were abrupt, not tapered, an observational study showed.



Long-term opioid discontinuations among Medicare Part D beneficiaries increased by 49% from

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