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ICI Arthritis Tied to Cancer Progression

Oct 14, 2020

Cancer patients treated with immune checkpoint inhibitors (ICI) who develop severe arthritis may be at risk for progression of the malignancy, a single-center study suggested.

Almost 90% of patients treated with ICI develop immune-related adverse events, which can include pulmonary,

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FDA Issues Final Guidance for Labeling Recommendations on Breast Implants, after review of data & commentary. Implants have been assoc w/anaplastic large cell lymphoma & breast implant illness (BII) w/ fatigue, “brain fog,” rash, myalgia, arthralgia. .

Dr. John Cush RheumNow ( View Tweet)

Oct 02, 2020

In Lupus, Older Age and Male Sex Raise Cancer Risk

Aug 25, 2020

Among patients with systemic lupus erythematosus (SLE), cancer risks overall were associated with older age at diagnosis and male sex, and lung cancer specifically was related to smoking, analysis of data from a large multicenter cohort found.

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Hong Kong study Myositis-specific autoantibodies in 201 pts with idiopathic inflammatory myopathies (IIM) shows MDA-5 (14%), TIFF-1γ (14%), Jo-(12.4%). MDA5 seen w/ DM, digital ulcers, amyopathy, ILD.

Dr. John Cush RheumNow ( View Tweet)

Aug 07, 2020
Systematic review of DYSPHAGIA in inflammatory myositis finds it may be an initial or sole symptom. Prevalence in IIM was 36% and higher 56% inclusion body myositis, cancer or NXP2 -associated myositis.

Dr. John Cush RheumNow ( View Tweet)

Jul 16, 2020
Nested case-control study of 5858 SLE patients - 51 developed cancer; most common were thyroid CA (27%), cervical (20%), & lung (14%). No risk imposed by steroids, CTX, MTX or azathioprine.

Dr. John Cush RheumNow ( View Tweet)

Jul 01, 2020
High uric acid is associated with a higher risk of kidney cancer, especially in women; Data from a UK biobank of 444 462 without cancer w/ 6.5 yrs F/U. Highest Urate quartile had increased risk of renal cancer (HR 1.45, 95%CI 1.08 to 1.93), only in women.

Dr. John Cush RheumNow ( View Tweet)

Jun 26, 2020

Adverse Events With Rheum Biologics Rise With Age

Jun 23, 2020

Among patients with rheumatic diseases, age and female sex were important factors associated with the development of a first adverse event after initiating biologic treatment, Spanish researchers reported.

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#EULAR2020 #op0143 a nationwide study concludes GCA pts at higher risk for sarcoma (HR 2.14), kidney cancer (1.6), hematological malignancies (HL2.42&non-HL1.66). Overall cancer HR 1.29.
Olga Petryna DrPetryna ( View Tweet)
Jun 07, 2020
GCA and cancer: it's been hard to tease apart, lots of cofounders. We've needed large cohorts with comparators & detail. Large Israeli database says there are links (EMR/claims/prescribing combined, n = 4.4m w validated incident GCA set).
David Liew drdavidliew ( View Tweet)
Jun 05, 2020
AAV/PAN and cancer: risk from meds has always been the question. Interesting therefore that GPA/MPA pts accumulated incident cancer risk over time, whereas other AAV/PAN pts had risk early after dx... Jo Tieu 🇦🇺@earlyARA @helenkeen73 @CatherineL_Hill OP0145 #EULAR2020 @RheumNow
David Liew drdavidliew ( View Tweet)
Jun 05, 2020

No Certain Link between Biologics and Melanoma Risk

May 21, 2020

A review of available data fails to show an increased risk of melanoma in IMID (inflammatory bowel disease, rheumatoid arthritis, and psoriasis) patients treated with systemic biologic therapies.  

There have been sporadic uncontrolled observational reports suggesting a link between

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FDA Consumer Warnings on Cannabis and CBD

Apr 23, 2020

The FDA issued a new consumer update on what you need to know about Cannabis or Cannabis-derived Compounds, Including CBD. This is part of the FDA effort to answer questions about the science, safety, and quality of products containing cannabis and cannabis-derived compounds, particularly CBD

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ACR COVID-19 Guidance for Rheumatic Disease Patients

Apr 14, 2020

On April 11th, the ACR Board of Directors approved a COVID-19 guidance document written by an ACR task force charged with updating and clarifying recommendations for rheumatologists and rheumatic disease patient management during the current COVID-19 crisis.

This ACR release, in its

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Post 9/11 Autoimmune Disease Risk

Apr 14, 2020

The 9/11/01 terrorist attach on the World Trade Center (WTC)  resulted in at least 2,977 fatalities, over 25,000 injuries, and caused at least $10 billion in infrastructure and property damage.  Arthritis & Rheumatology reports that dust cloud exposure among responders and PTSD

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TNR - Grand Rounds: Safety of Biologics & New Agents

Apr 08, 2020

On Tuesday, April 7th, RheumNow hosted its first Tuesday Nite Rheumatology webinar - kicking off a two-month series of Rheumatology Grand Rounds lectures.  The first session featured Jack Cush, MD (UT Southwestern) who lectured on "The Safety of Biologics and Newer Agents".

This 30

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NICE Guidelines on Managing Rheumatologic Conditions During COVID-19 Pandemic

Apr 07, 2020

On April 3rd, the National Institute for Health and Care Excellence (NICE) in the UK, published a rapid guideline for managing children and adults with rheumatological autoimmune, inflammatory and metabolic bone disorders during the COVID-19 pandemic, while protecting staff from infection.

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Malignancies with Giant Cell Arteritis

Mar 11, 2020

The Journal of Rheumatology reports the findings of a Swedish population-based cohort study of biopsy-proven giant cell arteritis (GCA) patients showing that the overall risk for cancer was not increased; yet there appears to be an increased risk for leukemia and a decreased risk for breast

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No Cancer Increase in Psoriatic Arthritis or with Biologics in Psoriasis

Feb 21, 2020

JAMA Dermatology reports that psoriasis is associated with a slightly increased risk of cancer, particularly keratinocyte cancer and lymphomas.

A systematic review and meta-analysis of 112 studies including more than 2 million patients, also shows no increase in when psoriasis

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RheumNow Podcast- Knee Pain Knockout (1.10.20)

Jan 10, 2020

Dr. Jack Cush reviews the news and journal reports from this past week on The podcast covers: best therapies for dactylitis and enthesitis; we have a new knockout for knee pain in OA; and are you on the naughty or nice list when it comes to the new ACR-AF guidelines for arthritis?

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CORRONA registry 880 RA pts developed a solid cancer. 42% taking bDMARD/tsDMARD; 5% switched biologics w/in 36 mos & 10% started a new biologic- w/ most changing to a TNFi (53%). ACR guidelines say to Rx regardless of solid tumor

Dr. John Cush RheumNow ( View Tweet)

Jan 07, 2020

Best of 2019 - Biologic Safety Guidelines from the British Society for Rheumatology

Jan 01, 2020

In the United Kingdom, NICE has looked to the British Society of Rheumatology (BSR) to develop evidence based guidance on the safe use of biologic DMARDs in patients with inflammatory arthritis. This guidance document on biologic safety covers baseline screening, monitoring, effect of co-

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Best of 2019 - Ups and Downs with Abatacept

Dec 31, 2019

Two recent studies have examined the effect of starting abatacept upon the risk of serious hospitalized infections or cancer, showing divergent results from claims data analyses.

Chen and colleagues reported in Arthritis Care & Research on a propensity score-matched cohort

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No Cancer Risk with Systemic Necrotizing Vasculitis

Dec 16, 2019

The French Vasculitis Study Group has published that patients with systemic necrotizing vasculitis do not have an increased risk of malignancy; in fact they have a risk that is similar to the general population.

Previous reports have suggested either no risk or a declining risk in the

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