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No Certain Link between Biologics and Melanoma Risk

May 21, 2020

A review of available data fails to show an increased risk of melanoma in IMID (inflammatory bowel disease, rheumatoid arthritis, and psoriasis) patients treated with systemic biologic therapies.  



There have been sporadic uncontrolled observational reports suggesting a link between

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FDA Consumer Warnings on Cannabis and CBD

Apr 23, 2020

The FDA issued a new consumer update on what you need to know about Cannabis or Cannabis-derived Compounds, Including CBD. This is part of the FDA effort to answer questions about the science, safety, and quality of products containing cannabis and cannabis-derived compounds, particularly CBD

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ACR COVID-19 Guidance for Rheumatic Disease Patients

Apr 14, 2020

On April 11th, the ACR Board of Directors approved a COVID-19 guidance document written by an ACR task force charged with updating and clarifying recommendations for rheumatologists and rheumatic disease patient management during the current COVID-19 crisis.

This ACR release, in its

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Post 9/11 Autoimmune Disease Risk

Apr 14, 2020

The 9/11/01 terrorist attach on the World Trade Center (WTC)  resulted in at least 2,977 fatalities, over 25,000 injuries, and caused at least $10 billion in infrastructure and property damage.  Arthritis & Rheumatology reports that dust cloud exposure among responders and PTSD

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TNR - Grand Rounds: Safety of Biologics & New Agents

Apr 08, 2020

On Tuesday, April 7th, RheumNow hosted its first Tuesday Nite Rheumatology webinar - kicking off a two-month series of Rheumatology Grand Rounds lectures.  The first session featured Jack Cush, MD (UT Southwestern) who lectured on "The Safety of Biologics and Newer Agents".

This 30

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NICE Guidelines on Managing Rheumatologic Conditions During COVID-19 Pandemic

Apr 07, 2020

On April 3rd, the National Institute for Health and Care Excellence (NICE) in the UK, published a rapid guideline for managing children and adults with rheumatological autoimmune, inflammatory and metabolic bone disorders during the COVID-19 pandemic, while protecting staff from infection.

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Malignancies with Giant Cell Arteritis

Mar 11, 2020

The Journal of Rheumatology reports the findings of a Swedish population-based cohort study of biopsy-proven giant cell arteritis (GCA) patients showing that the overall risk for cancer was not increased; yet there appears to be an increased risk for leukemia and a decreased risk for breast

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No Cancer Increase in Psoriatic Arthritis or with Biologics in Psoriasis

Feb 21, 2020

JAMA Dermatology reports that psoriasis is associated with a slightly increased risk of cancer, particularly keratinocyte cancer and lymphomas.

A systematic review and meta-analysis of 112 studies including more than 2 million patients, also shows no increase in when psoriasis

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RheumNow Podcast- Knee Pain Knockout (1.10.20)

Jan 10, 2020

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com. The podcast covers: best therapies for dactylitis and enthesitis; we have a new knockout for knee pain in OA; and are you on the naughty or nice list when it comes to the new ACR-AF guidelines for arthritis?

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CORRONA registry 880 RA pts developed a solid cancer. 42% taking bDMARD/tsDMARD; 5% switched biologics w/in 36 mos & 10% started a new biologic- w/ most changing to a TNFi (53%). ACR guidelines say to Rx regardless of solid tumor https://t.co/pPgnYNdT7Q

Dr. John Cush RheumNow ( View Tweet)

Jan 07, 2020

Best of 2019 - Biologic Safety Guidelines from the British Society for Rheumatology

Jan 01, 2020

In the United Kingdom, NICE has looked to the British Society of Rheumatology (BSR) to develop evidence based guidance on the safe use of biologic DMARDs in patients with inflammatory arthritis. This guidance document on biologic safety covers baseline screening, monitoring, effect of co-

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Best of 2019 - Ups and Downs with Abatacept

Dec 31, 2019

Two recent studies have examined the effect of starting abatacept upon the risk of serious hospitalized infections or cancer, showing divergent results from claims data analyses.

Chen and colleagues reported in Arthritis Care & Research on a propensity score-matched cohort

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No Cancer Risk with Systemic Necrotizing Vasculitis

Dec 16, 2019

The French Vasculitis Study Group has published that patients with systemic necrotizing vasculitis do not have an increased risk of malignancy; in fact they have a risk that is similar to the general population.

Previous reports have suggested either no risk or a declining risk in the

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Biologic Safety Guidelines from the British Society for Rheumatology

Dec 05, 2019

In the United Kingdom, NICE has looked to the British Society of Rheumatology (BSR) to develop evidence based guidance on the safe use of biologic DMARDs in patients with inflammatory arthritis. This guidance document on biologic safety covers baseline screening, monitoring, effect of co-

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RheumNow Podcast – Better Ways to Treat Gout (11.8.19)

Nov 08, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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RheumNow Podcast – The Shoes Maketh the Doctor (10.25.19)

Oct 25, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com.

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Interleukin Targeted Biologics Increase Risks of Infection

Oct 21, 2019

A systematic review of the literature shows that, compared to placebo, the use of non-TNF, interleukin inhibitor biologics may be associated with significantly higher rates of serious infections, opportunistic infections, and cancer.

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RheumNow Podcast – When You’re Hot You’re Hot (10.11.19)

Oct 11, 2019

Dr. Jack Cush delivers select commentary on select news and journal articles from the past week on RheumNow.com.

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RheumNow Podcast – Women Take Over Rheumatology (10.4.19)

Oct 04, 2019

Dr. Jack Cush reviews the News and Journal Reports from this week on RheumNow.com.

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RheumNow Podcast – Cancer Risk in Systemic Sclerosis (9.27.19)

Sep 27, 2019

Dr. Jack Cush reviews the news and articles from the past week on RheumNow.com.

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Checkpoint Inhibitors: Who Gets Myocarditis?

Aug 28, 2019

The usual risk factors for myocarditis may not apply to who gets it while on immune checkpoint inhibiting cancer drugs, an FDA adverse event database suggested.

Myocarditis associated with immune checkpoint inhibitors (ICIs) was nearly twice as likely in women (OR 1.92, 95% CI 1.24-2.97

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With Autoimmunity, Checkpoint Inhibitors Can Be Used

Aug 14, 2019

Among patients with pre-existing autoimmune diseases who developed cancer and were treated with immune checkpoint inhibitors (ICI), flares of the underlying disease and other immune-related adverse events were common, a retrospective study conducted in France showed.

During a median

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RheumNow Podcast – Don’t Take My Advice (7.19.19)

Jul 19, 2019

Dr. Jack Cush reports the news and new journal articles from the past week on RheumNow.com.

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Understanding Non-arthritic Rheumatic iRAEs

Jun 17, 2019

A better understanding of rheumatic immune-related adverse event phenotypes beyond inflammatory arthritis has been furthered by work from three abstracts presented at EULAR 2019 in Madrid.

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