Dr. Quotes (11.8.2024)
Dr. Jack Cush reviews the news and journal reports from this past week from RheumNow.com.
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Dengue fever, a mosquitoborne viral illness, is increasing worldwide; during 2024, approximately 13 million cases have been reported in the Americas. 2010–2024, a total of 15,077 (38.6%) patients were hospitalized But the fatality rate is unchanged. 2023 DENV-3 recent outbreak in… https://t.co/BKrEmN4F6G https://t.co/WIXaPeex8Z
Dr. John Cush @RheumNow( View Tweet )
Small, suspended, post COVID randomized trial, guselkumab failed to show efficacy at reducing proteinuria in 33 SLE pts. Wk24 results, 56% placebo vs. 35% GUS for primary end point., No differences in secondary outcomes or adverse events https://t.co/27imkXkbUn https://t.co/yGdDQlu5v3
Dr. John Cush @RheumNow( View Tweet )
JAMA Patient Quiz - Joint Pain in a Woman Wearing a Face Mask https://t.co/fbUERrmzW4 https://t.co/KMJZqsSyMG
Dr. John Cush @RheumNow( View Tweet )
COVID Associated Immune Disease
Dr. Len Calabrese reports on a session he participated in discussing if Covid-19 is associated or causal for autoimmune disease. Reporting from #ACR24
https://t.co/vFdlf9XVzf https://t.co/JhpglNVIt7
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Dr. John Cush @RheumNow( View Tweet )
A systematic review & meta-analysis by Dr. JBCorrea et al show that the ff immune-mediated dses are assocd w/⬆️ ocurrence risk after covid19 infection 👇
Behcets
SpA
SS
SLE
PMR
Pso
RA
Sjogrens
T1DM
Vasculitis
IBD
Ask prior covid infexn in pts history
@RheumNow #ACR24 abs2614 https://t.co/TIEglPrmvL
sheila @RHEUMarampa( View Tweet )
Long COVID outcomes in Autoimmune diseases (AID)
Abstract 1897:
- Long COVID symptoms higher among AID pts vs controls
- vaccinated may have protective benefit
@RheumNow #ACR24 https://t.co/2SEcbkxfcU
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Akhil Sood MD @AkhilSoodMD( View Tweet )
To stop tsDMARD / bDMARD To improve #COVIDVACCINE response in those w several previous #COVID19 #vaccinations is NOT necessary
This will change my practice!
#ACR24 @RheumNow @ACRheum https://t.co/WXeqMOEfuA
Janet Pope @Janetbirdope( View Tweet )
Is #IL1 inhibition for 4 months a winner in #GCA —NOPE
Anakinra daily 100mg sc 4/12
Underpowered but equal relapses and d/c #steroids not different
#relapses esp after d/c #anakinra
N=30 d/c due to #COVIDpandemic
#1699 #ACR24 @RheumNow @ACRheum https://t.co/1TgloS5x8O
Janet Pope @Janetbirdope( View Tweet )
Study on SLE treatments:
Compared adverse events of anifrolumab vs. belimumab
Similar risks for mortality, sepsis, herpes zoster, dialysis, MACE, PE/VTE, COVID-19, URI, pneumonia, and mental illness #ACR24 @RheumNow abst#1527
Bella Mehta @bella_mehta( View Tweet )
If high +ANA and NO #rheumatic #disease LOOK 👀 at #LIVER #Autoimmune #hepatitis And #alcoholic #liver #dx #ACRBest #ACR24 @rheumnow abst#0627 https://t.co/EVLUyvpBfD
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Janet Pope @Janetbirdope( View Tweet )
CKD keeps a persistent low grade inflammatory state! Implications: CKD ⬆️risk for CV dz through different mech @RheumNow #ACR24 https://t.co/KcCvyTVaav
TheDaoIndex @KDAO2011( View Tweet )
COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders
A Korean population based study found that people infected with COVID-19, especially severe COVID-19, had an increased risk of autoimmune and autoinflammatory connective tissue disorders.… https://t.co/zlJrusJDM4 https://t.co/cuumClbN6b
Dr. John Cush @RheumNow( View Tweet )
Long Covid Defined
While COVID-19 has infected over 7 million worldwide, it is estimated that 7% of adults (and >1% of children) or 15 to 20 million Americans have developed long COVID, a chronic condition with systemic and often disabling symptoms.
https://t.co/9njt8Kqe7P https://t.co/2V5OVlUrfQ
Dr. John Cush @RheumNow( View Tweet )
COVID-19 and Long-Term Risk of Autoimmune and Autoinflammatory Disorders
A Korean population based study found that people infected with COVID-19, especially severe COVID-19, had an increased risk of autoimmune and autoinflammatory connective tissue disorders.
While several observational studies have suggested an association between COVID-19 and future
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Singapore study of Autoimmune (AIRD) risk w/ COVID infx compared 104 179 DELTA + pts vs 666 575 PCR neg controls (~80+% Vax) & 375 903 Omicron+ vs 619 379 controls (~75% boosted). Found no signif incr risk of AIRD w/ COVID infx. https://t.co/gXzWdotzvL https://t.co/UsQpwgsyTD
Dr. John Cush @RheumNow( View Tweet )
The new Covid KP.2 booster vaccines are becoming available throughout the US. Besides high-risk (e.g. age 65+, immunocompromised, comorbidities), one of the most important reasons to get boosted, often overlooked, is to reduce #LongCovid risk by ~50%. Agree with Marks at FDA… https://t.co/SgX7JiPRzH https://t.co/i0W4xadxjW
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Eric Topol @EricTopol( View Tweet )
Anti-Inflammatory Diet yields a lower risk of Dementia. UK Biobank study shows patients w/ type 2 diabetes, heart disease, or stroke who were on an anti-inflammatory diet had a 31% lower risk for dementia vs. a pro-inflammatory diet https://t.co/OjHq3BBOfd https://t.co/tG9vO59IEc
Dr. John Cush @RheumNow( View Tweet )
3+ million persons died in USA in 2023. Overall age-adjusted death rate in 2023 was 6.1% lower than 2022. Overall death rate highest among non-Hispanic Blacks or African Americans. The number of COVID-19 deaths was 68.9% lower than in 2022 https://t.co/Oqgxcs4yUz https://t.co/lDn1PuEQ5Z
Dr. John Cush @RheumNow( View Tweet )
Study of 4378 pts COVID tested betw 2020-22, found low risk (3-4%)of myalgic encephalomyelitis/chronic fatigue syndr (ME/CFS) subsequent to SARS-CoV-2 infx, w/ no difference betw COVID test pos & neg. (OR 0.84; 0.42-1.67) Not supporting long COVID as FM? https://t.co/M0NWvuxT2n https://t.co/hoW5sVOYcN
Dr. John Cush @RheumNow( View Tweet )
Decline in Physician Trust During the COVID-19 Pandemic
AMA reports that following the COVID-19 pandemic US adults trust in physicians and hospitals decreased, and was associated with lower odds of COVID vaccination.
https://t.co/3XcMYcnzD3 https://t.co/yiIvOp1o5a
Dr. John Cush @RheumNow( View Tweet )
Arthritis drugs may relieve long COVID lung symptoms
University of Virginia SOM researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs.
https://t.co/4gqVhzOEMg https://t.co/NEysSjRE8c
Dr. John Cush @RheumNow( View Tweet )
Decline in Physician Trust During the COVID-19 Pandemic
JAMA reports that following the COVID-19 pandemic US adults trust in physicians and hospitals decreased, and was associated with lower odds of COVID vaccination.
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Arthritis drugs may relieve long COVID lung symptoms
EurekAlert!
University of Virginia School of Medicine researchers have identified a potential treatment for the respiratory symptoms of long COVID after discovering an unknown cause of the condition inside the lungs.
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@RheumNow The always erudite @LCalabreseDO is no slouch of a debating opponent, however. He acknowledges that the science has been imperfect, too much is wrapped up in it, and that fibromyalgia can teach a lot to long COVID. #EULAR2024 @RheumNow https://t.co/TzR4SMZh9f
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David Liew @drdavidliew( View Tweet )
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