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Genetics

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CC Genotype and Thiopurine Toxicity

Jun 20, 2022

Annals of Internal Medicine reports that thiopurine toxcicity risk is associated with the "CC" genotype and that azathioprine discontinuation was associated with hematopoietic toxicity and lower thiopurine doses. 



Prior studies have shown that azathiprine (AZA) use is associated with

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Polygenic Risk Scores to Identfy Severe Knee and Hip Osteoarthritis

May 09, 2022

Prevention of knee and hip osteoarthritis would obviate considerable disability and future surgery.  We may be one step closer according to a prospective European GWAS study showing polygenic risk scores (PRSs) significantly associated with higher risks for knee and hip OA joint replacement

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Arthritis Predicts Hepatic Fibrosis in Hemochromatosis

Apr 25, 2022

Mayo Clinic Proceedings reports the results of a retrospective, cross-sectional of patients with HFE hemochromatosis showing that advanced hepatic fibrosis is primarily seen in those with arthritis due to HFE hemochromatosis. 



A total of 112 patients with a liver biopsy confirmed

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#Rheumatoid arthritis- is it all or partially in your genes 🧬? Many genes are not sufficient or necessary to produce #RA. Genes were used in a study to predict development of RA better than clinical parameters. But not ready for prime time YET #RNL2022 @RheumNow @karen_kc123 https://t.co/J5aBs4iLbR
Mar 20, 2022
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Consequences of TNF inhibition (3.18.2022)

Mar 18, 2022

This week we're going to talk about the downside of TNF inhibitors, a few interesting observations in gout, and yes, kids do get COVID. We're also going to preview what's coming in April (hint: it's about PsA). This and more as Dr. Jack Cush reviews the news and journal articles from the past

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Environmental Pollutants Ups Autoimmune Disease Risk

Mar 16, 2022

An Italian environmental study shows that air pollution increases the risk of autoimmune diseases, in particular rheumatoid arthritis, connective tissue diseases (CTDs) and inflammatory bowel diseases (IBD).



Previously environmental pollutants have been linked to an increased risk of

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Predicting Spondylitis in At-Risk Relatives

Mar 14, 2022

The risk of developing axial spondyloarthritis (axSpA) if you’re a first-degree relative (FDRs) of an ankylosing spondylitis (AS) patient has been deflined by a 35 year follow-up study showing that if you are a FDR of axSpA you may be at higher risk of acute anterior uveitis (AAU).

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An Ounce of Prevention (2.4.2022)

Feb 03, 2022

Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.  He discusses the GI side effects of IL-17 inhibitors, downstream revenues from rheumatology care and dietary prevention of gout. 

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Genes and Obesity Tied to Higher Gout Risk in Women

Dec 09, 2021

Excess adiposity and genetic predisposition both contributed to risk of gout among U.S. women, with the risks being highest when both factors are present, a large prospective study found.



Analysis of data from the Nurses' Health Study (NHS) found that the relative risk for incident

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Cytokine Inhibitor Lung Disease in Still's Linked to HLA-DRB1 Alleles

Dec 01, 2021

Pulmonary complications in the setting of Still's disease (juvenile and adult) has seldom but consistently been reported, including reports of pneumonitis, pulmonary hypertension and a severe or fatal lung disease, often associated with hypersensitivity to anticytokine therapy. A multicenter

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RheumNow Podcast - ACR 2021 Rehash (the good stuff..)

Nov 12, 2021

The ACR 2021 meeting has concluded. Dr. Jack Cush recounts a few more great abstracts from this past week’s virtual meeting.

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Opening Day Report

Nov 06, 2021

The opening of ACR2 Convergence was a hit for all who signed up and viewed in. The day included the presidential address by outgoing president Dr. David Karp (UT Southwestern) and a keynote talk and interview with Dr. Seema Yasmin (Stanford).



The Year in Review

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Clues to Survival and Mortality with VEXAS Syndrome

ACR
Nov 01, 2021

New research to be presented this week at ACR Convergence, the American College of Rheumatology’s annual meeting, shows a relationship between genotype, bone marrow failure and survival in patients with the rare autoinflammatory disease VEXAS syndrome, which was only identified in 2020.

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Large GWAS Study Reveals Genetic Basis for Osteoarthritis Phenotypes

Oct 29, 2021

Cell has published the results of a multinational, GWAS meta-analyses of 826,690 individuals that included 177,517 osteoarthritis patients, finding 52 previously unknown osteoarthritis (OA) genetic risk variants and linking OA genetic risks with joint distribution and pain-related

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Passive Smoke Exposure and Rheumatoid Risk

Aug 23, 2021

A current report in Arthritis & Rheumatology examined the Nurses Health Study II data set and shows that parental smoking, and passive exposure to children, can later lead to an increased risk of adult-onset incident seropositive rheumatoid arthritis (RA).

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RA Hands Difficult deformity

What Factors Predict RA in First-Degree Relatives?

MedPage Today
Aug 16, 2021

Among a cohort of first-degree relatives of patients with rheumatoid arthritis (RA), certain patient characteristics, as well as symptoms, helped predict a possible increased risk for developing the disease, U.K. researchers reported.



In a group of 870 first-degree relatives, 13.3%

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tea

More Tea, Less Rheumatoid

Aug 09, 2021

A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.



Tea consumption was quantified in 2237 incident RA cases (2005–2018) and 4661 controls, who were matched on age, sex, and residential area. Tea

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Is Pre-Clinical Spondyloarthritis a Real Risk?

Jul 12, 2021

A study of first-degree relatives (FDRs) of HLA-B27-positive axial spondyloarthritis (axSpA) patients shows clinical or imaging features of spondyloarthritis in up to 32% subjects, regardless of HLA-B27 status.



Historically, it has been suggested there is a 20% risk of ankylosing

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RheumNow Podcast – Myth Busters (5.21.2021)

May 21, 2021

Dr Jack Cush reviews the news and journal reports from the past week on RheumNow.com




  1. Metanalysis (11 RCTs, 19 registries) of Pulm arterial HTN assoc. w/ CTD (w/ 1,267 & 4,008 CTD-PAH pts), showed Investigational Rxs reduced morbidity/mortality by 36%. CTD-PAH survival

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Childhood Lupus May Hamper Adult Careers

May 04, 2021

Long-term outcomes of kids with childhood-onset systemic lupus erythematosus (cSLE) are uncommon, but this cSLE cohort analysis suggests that SLE significantly impacts their future education, vocation, and employment as they reach adulthood.



A cohort of 106 cSLE (93% female, 73% White

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New, Improved Therapy for Pompe Disease

Apr 16, 2021

Researchers from the University of Cincinnati Gardner Neuroscience Institute will present data on a new treatment for Pompe disease at the American Academy of Neurology on April 20th; the results show that treatment with avalglucosidase alfa yielded substantial clinical improvements and a more

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RheumNow Podcast – Systemic Sclerosis Pearls (2.19.2021)

Feb 18, 2021

Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on RheumNow.com, including the ACR's new COVID-19 vaccine guidance for patients with rheumatic disease.

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One-Third Rheumatoid Risk from Lifestyle

Feb 01, 2021

Analysis of the NHANES (National Health and Nutrition Examination Survey) data suggests that one-third of the risk of developing rheumatoid arthritis (RA) in the USA is attributable smoking, obesity and alcohol intake.



NHANES was used to determine the prevalence of lifestyle exposures

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Delays in Diagnosis of Axial Spondyloarthritis

Jan 12, 2021

The diagnosis of axial spondyloarthritis (and anklylosing spondylitis) (axSpA) is often delayed and usually not diagnosed by rheumatologists; a recent metanalysis shows that longer delays were attributable to lower education levels, younger age at onset and absence of extra-articular

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ACR20 Podcast

ACR20 - Autoinflammatory & Still's Disease Panel

Nov 24, 2020

This podcast features a discussion of autoinflammatory and Still's disease abstracts from virtual ACR 2020. Dr. Jack Cush is joined by a panel of experts including Drs. Olga Petryna, Bella Metha and Michael Ombrello.



You can listen to this podcast on SoundCloud, iTunes, Apple Car Play

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