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Passive Smoke Exposure and Rheumatoid Risk

Aug 23, 2021

A current report in Arthritis & Rheumatology examined the Nurses Health Study II data set and shows that parental smoking, and passive exposure to children, can later lead to an increased risk of adult-onset incident seropositive rheumatoid arthritis (RA).

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What Factors Predict RA in First-Degree Relatives?

MedPage Today
Aug 16, 2021

Among a cohort of first-degree relatives of patients with rheumatoid arthritis (RA), certain patient characteristics, as well as symptoms, helped predict a possible increased risk for developing the disease, U.K. researchers reported.

In a group of 870 first-degree relatives, 13.3%

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More Tea, Less Rheumatoid

Aug 09, 2021

A large cohort study of rheumatoid arthritis (RA) patients shows that regular tea consumption was associated with a lower risk of RA.

Tea consumption was quantified in 2237 incident RA cases (2005–2018) and 4661 controls, who were matched on age, sex, and residential area. Tea

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Is Pre-Clinical Spondyloarthritis a Real Risk?

Jul 12, 2021

A study of first-degree relatives (FDRs) of HLA-B27-positive axial spondyloarthritis (axSpA) patients shows clinical or imaging features of spondyloarthritis in up to 32% subjects, regardless of HLA-B27 status.

Historically, it has been suggested there is a 20% risk of ankylosing

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RheumNow Podcast – Myth Busters (5.21.2021)

May 21, 2021

Dr Jack Cush reviews the news and journal reports from the past week on

  1. Metanalysis (11 RCTs, 19 registries) of Pulm arterial HTN assoc. w/ CTD (w/ 1,267 & 4,008 CTD-PAH pts), showed Investigational Rxs reduced morbidity/mortality by 36%. CTD-PAH survival

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Childhood Lupus May Hamper Adult Careers

May 04, 2021

Long-term outcomes of kids with childhood-onset systemic lupus erythematosus (cSLE) are uncommon, but this cSLE cohort analysis suggests that SLE significantly impacts their future education, vocation, and employment as they reach adulthood.

A cohort of 106 cSLE (93% female, 73% White

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New, Improved Therapy for Pompe Disease

Apr 16, 2021

Researchers from the University of Cincinnati Gardner Neuroscience Institute will present data on a new treatment for Pompe disease at the American Academy of Neurology on April 20th; the results show that treatment with avalglucosidase alfa yielded substantial clinical improvements and a more

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RheumNow Podcast – Systemic Sclerosis Pearls (2.19.2021)

Feb 18, 2021

Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on, including the ACR's new COVID-19 vaccine guidance for patients with rheumatic disease.

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One-Third Rheumatoid Risk from Lifestyle

Feb 01, 2021

Analysis of the NHANES (National Health and Nutrition Examination Survey) data suggests that one-third of the risk of developing rheumatoid arthritis (RA) in the USA is attributable smoking, obesity and alcohol intake.

NHANES was used to determine the prevalence of lifestyle exposures

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Delays in Diagnosis of Axial Spondyloarthritis

Jan 12, 2021

The diagnosis of axial spondyloarthritis (and anklylosing spondylitis) (axSpA) is often delayed and usually not diagnosed by rheumatologists; a recent metanalysis shows that longer delays were attributable to lower education levels, younger age at onset and absence of extra-articular

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ACR20 - Autoinflammatory & Still's Disease Panel

Nov 24, 2020

This podcast features a discussion of autoinflammatory and Still's disease abstracts from virtual ACR 2020. Dr. Jack Cush is joined by a panel of experts including Drs. Olga Petryna, Bella Metha and Michael Ombrello.

You can listen to this podcast on SoundCloud, iTunes, Apple Car Play

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Undifferentiated Autoinflammatory Syndrome Called VEXAS

Nov 24, 2020

Saturday's session on autoinflammatory syndromes featured Dr. Dan Kastner addressing - The Adult with Undifferentiated Autoinflammatory Disease.

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

Oct 06, 2020

A study of oral microbiome in anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals without synovitis (CCP+at risk) shows dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls.

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RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

Sep 24, 2020

Dr. Jack Cush reviews the news and Journal articles from the past week on

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CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

Sep 21, 2020

Research from Oxford University suggests a potential pathogenic role for the chemokine CXCR3 and clonally restricted CD8+ T cells in the pathogenesis of psoriatic arthritis (PsA) based studies of PsA synovial fluid samples obtained by arthrocentesis from 11 patients with large-joint oligo PsA

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PRIME Cells Predicting Rheumatoid Arthritis Flares

Jul 16, 2020

The current issue of NEJM reports a novel cell type that may be used to identify rheumatoid arthritis (RA) patients who may flare. 

Investigators prospectively collected blood samples from 4 patients for longitudinal RNA sequencing (RNA-seq) for discovery of moleculartranscripts that were

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Periodontal Disease and P. gingivalis Increased in CCP+ Pre-Clinical RA

Aug 07, 2019

A cross-sectional study 48 CCP–positive "at risk" individuals (without arthritis) were shown to have an increased prevalence of periodontitis and P gingivalis when compared to 26 early RA (ERA) and 32 controls.

anti–cyclic citrullinated protein–positive at-risk individuals (CCP+ at-

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Management of Hemophagocytic Lymphohistiocytosis (HLH) in Adults

Jun 11, 2019

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome induced by activated macrophages and cytotoxic T cells.  HLH manifests recurrent fever, cytopenia, liver dysfunction, and a sepsis-like syndrome that may complicated by multiple organ failure. While HLH is rarely

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Lupus Outcomes Influenced by Race/Ethnicity

May 22, 2019

A lupus registry from San Francisco County analyzed racial/ethnic differences in lupus manifestations and found significant differences in SLE manifestations among racial/ethnic groups. Researchers found that Blacks, Asians/Pacific Islanders (API), and Hispanics are more likely to develop severe

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RheumNow Podcast – Take it Back Jack! (4.26.19)

Apr 26, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on

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Autoimmune Disease Clustering at ENDO 2019

Mar 25, 2019

A twin registry database study was presented at the Endocrine Society's annual meeting (ENDO 2019) in New Orleans, showed that that having autoimmune disease significantly increases the risk of other autoimmune disorders and that autoimmune clustering was highest in Addison's disease and

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RheumNow Podcast - MTX vs. Etanercept in Psoriatic Arthritis (2.15.19)

Feb 15, 2019

Dr. Jack Cush discusses the news from the past week on - including the SEAM trial, MRI guided T2T, biologics and infection, contraceptive use, ANA negative lupus, etc.

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Differing Effects of Smoking and HLA-DRB1 in Seropositive Rheumatoids

Feb 12, 2019

Analyses from the Swedish EIRA incident rheumatoid arthritis cohort study shows that smoking and HLA-DRB1 exert differential effects on serologically defined RA subsets - but that the strongest influence was seen in double positive (CCP+, RF+) individuals.

These investigators have

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Ten Contemporary Challenges Facing Lupus Treatment

Feb 11, 2019

A group of French researchers have pooled their interests to identify the challenges ahead in the management of patients with systemic lupus erythematosus (SLE). 

This introspective review puts forth the authors’ perceptions of the 10 most important contemporary challenges in the

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Genetic Diagnosis for Previously Undiagnosed Disorders

Dec 11, 2018

The NEJM has reported the NIH's Undiagnosed Diseases Network (UDN) study results of genetically identifying new diseases from prospectively followed persons with undiagnosed disorders.

The UDN was formed in 2014 as a network of seven clinical sites, two sequencing cores, a coordinating center

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