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Genetics

Periodontal Disease and P. gingivalis Increased in CCP+ Pre-Clinical RA

Aug 07, 2019

A cross-sectional study 48 CCP–positive "at risk" individuals (without arthritis) were shown to have an increased prevalence of periodontitis and P gingivalis when compared to 26 early RA (ERA) and 32 controls.

anti–cyclic citrullinated protein–positive at-risk individuals (CCP+ at-risk

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Management of Hemophagocytic Lymphohistiocytosis (HLH) in Adults

Jun 11, 2019

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome induced by activated macrophages and cytotoxic T cells.  HLH manifests recurrent fever, cytopenia, liver dysfunction, and a sepsis-like syndrome that may complicated by multiple organ failure. While HLH is rarely

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Lupus Outcomes Influenced by Race/Ethnicity

May 22, 2019

A lupus registry from San Francisco County analyzed racial/ethnic differences in lupus manifestations and found significant differences in SLE manifestations among racial/ethnic groups. Researchers found that Blacks, Asians/Pacific Islanders (API), and Hispanics are more likely to develop severe

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RheumNow Podcast – Take it Back Jack! (4.26.19)

Apr 26, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com

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Autoimmune Disease Clustering at ENDO 2019

Mar 25, 2019

A twin registry database study was presented at the Endocrine Society's annual meeting (ENDO 2019) in New Orleans, showed that that having autoimmune disease significantly increases the risk of other autoimmune disorders and that autoimmune clustering was highest in Addison's disease and

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RheumNow Podcast - MTX vs. Etanercept in Psoriatic Arthritis (2.15.19)

Feb 15, 2019

Dr. Jack Cush discusses the news from the past week on RheumNow.com - including the SEAM trial, MRI guided T2T, biologics and infection, contraceptive use, ANA negative lupus, etc.

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Differing Effects of Smoking and HLA-DRB1 in Seropositive Rheumatoids

Feb 12, 2019

Analyses from the Swedish EIRA incident rheumatoid arthritis cohort study shows that smoking and HLA-DRB1 exert differential effects on serologically defined RA subsets - but that the strongest influence was seen in double positive (CCP+, RF+) individuals.

These investigators have

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Ten Contemporary Challenges Facing Lupus Treatment

Feb 11, 2019

A group of French researchers have pooled their interests to identify the challenges ahead in the management of patients with systemic lupus erythematosus (SLE). 

This introspective review puts forth the authors’ perceptions of the 10 most important contemporary challenges in the

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Genetic Diagnosis for Previously Undiagnosed Disorders

Dec 11, 2018

The NEJM has reported the NIH's Undiagnosed Diseases Network (UDN) study results of genetically identifying new diseases from prospectively followed persons with undiagnosed disorders.

The UDN was formed in 2014 as a network of seven clinical sites, two sequencing cores, a coordinating center

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RheumNow Podcast – Can RA Be Prevented (12.7.18)

Dec 07, 2018

Dr. Jack Cush reviews the news and new journal articles from the past week on RheumNow.com:

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It's the Genes, Not the Diet that Raises Urate

Oct 18, 2018

Researchers from New Zealand find that in contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population.

A total of 16,760 adults of European ancestry from the US were included in analyses. They were without kidney disease or

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The RheumNow Week in Review – No Good Gout (8.10.18)

Aug 10, 2018

Dr. Jack Cush reviews the news and latest journal articles from the past week on RheumNow.com. Info on Surgery and Hip Fractures, Gout drugs abandoned, Allopurinol escalation, hydroxychloroquine drug levels, how to treat scleroderma in India and exactly who gets back pain.

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Selective Use of HLA-B*5801 Testing in Gout

Aug 07, 2018

The current edition of JAMA Internal Medicine describes an Asian gout patient who presents with an allopurinol hypersensitivity reaction that could have been diagnosed by testing for HLA-B*5801.

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Epigenetic Link in Rheumatoid Arthritis to Huntington's Disease

May 15, 2018

Researchers at University of California San Diego School and the Icahn School of Medicine have found a high-resolution epigenomic landscape of rheumatoid arthritis (RA) that overlaps with that seen in Huntington's disease, suggesting potentially new unanticipated pathways that could be

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The RheumNow Week in Review – Why Comorbidity is Like the Weather (5.3.18)

May 04, 2018

Dr. Jack Cush discusses the news and journal articles from the past week on RheumNow.com.

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Genetic Breakthrough in Systemic JIA

May 02, 2018

The identification of a genetic susceptibility locus for systemic juvenile idiopathic arthritis (sJIA) has important implications for treatment of this severe, poorly understood illness, researchers reported.

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Shared Epitope - Smoking Pathogenic Link Clarified

Apr 19, 2018

Proceedings of the National Academy of Sciences (PNAS) has published new research on the mechanistic link between the rheumatoid arthritis (RA) "shared epitope" (SE) risk alleles and environmental triggers such as cigarette smoke that leads to joint inflammation and bony destruction

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Precision Genetics Can Predict Methotrexate Non-Responders

Mar 29, 2018

Investigators from Glasgow and Oxford have identified changes in genomic architecture, represented by a chromosome conformation signature, that can predict nonresponse to methotrexate in early rheumatoid arthritis patients.

Recognizing that studies show 35–59% of RA patients do not

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Cumulative Genetic Hit Hypothesis for Lupus

Jul 18, 2017

A recent report in Nature Communications has studied multiple nationalities has shown a "disentangled complex HLA multigenic effect" underlying the genetic basis of systemic lupus erythematosus (SLE).  (Citation source: http://buff.ly/2u623Ht)

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Linkage Between Gut and Joint Immunity in Rheumatoid Arthritis

Jun 29, 2017

Pianta, et al have published their findings in the Journal of Clinical Investigation showing that two novel autoantigens, GNS and FLNA, are highly expressed in synovium and share a sequence homology with gut microbesa; thereby providing a potential link between gut mucosal and joint

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Potential Reasons Why Osteoarthritis Preferentially Affects Women

Jun 29, 2017

Researchers from Augusta University have examined exosomes from patients with knee osteoarthritis (OA) to enhance our molecular understanding of the pathogenesis of OA. (Citation source http://buff.ly/2tuDZ3v)

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First Degree Relatives and the Risk of Spondyloarthritis

Oct 11, 2016

The risk of developing ankylosing spondylitis (AS) if you are HLA-B27+ and a first degree relative is often said to be 20%.

Turina et al. set out to assess the risk of seemingly healthy first-degree relatives of AS based on whether they develop clinical, laboratory, or imaging features

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RheumNow Week in Review – 7 October 2016

Oct 07, 2016

Dr. Jack Cush reviews highlights from the journals and news this week on RheumNow.com.

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Canakinumab Yields Genetic and Disease Modifying Effects in TRAPS Patients

Aug 01, 2016


Tumor necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease resulting from mutations of the TNF super family receptor 1A (TNFRSF1A) gene.

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Epigenetic Changes to Inflammasome Found in Autoinflammatory Syndromes

Jul 21, 2016

The gene mutations underlying inflammasome activity have been well described, but there appears to be variable penetrance among patients with the same gene mutation, suggesting additional mechanisms may influence disease expression.

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