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Delays in Diagnosis of Axial Spondyloarthritis

Jan 12, 2021

The diagnosis of axial spondyloarthritis (and anklylosing spondylitis) (axSpA) is often delayed and usually not diagnosed by rheumatologists; a recent metanalysis shows that longer delays were attributable to lower education levels, younger age at onset and absence of extra-articular

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ACR20 - Autoinflammatory & Still's Disease Panel

Nov 24, 2020

This podcast features a discussion of autoinflammatory and Still's disease abstracts from virtual ACR 2020. Dr. Jack Cush is joined by a panel of experts including Drs. Olga Petryna, Bella Metha and Michael Ombrello.

You can listen to this podcast on SoundCloud, iTunes, Apple Car Play

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Undifferentiated Autoinflammatory Syndrome Called VEXAS

Nov 24, 2020

Saturday's session on autoinflammatory syndromes featured Dr. Dan Kastner addressing - The Adult with Undifferentiated Autoinflammatory Disease.

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Oral Dysbiosis May Antedate Rheumatoid Arthritis

Oct 06, 2020

A study of oral microbiome in anti-cyclic citrullinated peptide (anti-CCP) positive at-risk individuals without synovitis (CCP+at risk) shows dysbiotic subgingival microbiomes and increased abundance of P. gingivalis compared with controls.

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RheumNow Podcast – Cardiovascular Risk in Psoriatic Disease (9.25.20)

Sep 24, 2020

Dr. Jack Cush reviews the news and Journal articles from the past week on

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CXCR3 and Restricted T Cells in Psoriatic Arthritis Inflammation

Sep 21, 2020

Research from Oxford University suggests a potential pathogenic role for the chemokine CXCR3 and clonally restricted CD8+ T cells in the pathogenesis of psoriatic arthritis (PsA) based studies of PsA synovial fluid samples obtained by arthrocentesis from 11 patients with large-joint oligo PsA

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PRIME Cells Predicting Rheumatoid Arthritis Flares

Jul 16, 2020

The current issue of NEJM reports a novel cell type that may be used to identify rheumatoid arthritis (RA) patients who may flare. 

Investigators prospectively collected blood samples from 4 patients for longitudinal RNA sequencing (RNA-seq) for discovery of moleculartranscripts that were

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Periodontal Disease and P. gingivalis Increased in CCP+ Pre-Clinical RA

Aug 07, 2019

A cross-sectional study 48 CCP–positive "at risk" individuals (without arthritis) were shown to have an increased prevalence of periodontitis and P gingivalis when compared to 26 early RA (ERA) and 32 controls.

anti–cyclic citrullinated protein–positive at-risk individuals (CCP+ at-risk

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Management of Hemophagocytic Lymphohistiocytosis (HLH) in Adults

Jun 11, 2019

Hemophagocytic lymphohistiocytosis (HLH) is a severe hyperinflammatory syndrome induced by activated macrophages and cytotoxic T cells.  HLH manifests recurrent fever, cytopenia, liver dysfunction, and a sepsis-like syndrome that may complicated by multiple organ failure. While HLH is rarely

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Lupus Outcomes Influenced by Race/Ethnicity

May 22, 2019

A lupus registry from San Francisco County analyzed racial/ethnic differences in lupus manifestations and found significant differences in SLE manifestations among racial/ethnic groups. Researchers found that Blacks, Asians/Pacific Islanders (API), and Hispanics are more likely to develop severe

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RheumNow Podcast – Take it Back Jack! (4.26.19)

Apr 26, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on

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Autoimmune Disease Clustering at ENDO 2019

Mar 25, 2019

A twin registry database study was presented at the Endocrine Society's annual meeting (ENDO 2019) in New Orleans, showed that that having autoimmune disease significantly increases the risk of other autoimmune disorders and that autoimmune clustering was highest in Addison's disease and

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RheumNow Podcast - MTX vs. Etanercept in Psoriatic Arthritis (2.15.19)

Feb 15, 2019

Dr. Jack Cush discusses the news from the past week on - including the SEAM trial, MRI guided T2T, biologics and infection, contraceptive use, ANA negative lupus, etc.

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Differing Effects of Smoking and HLA-DRB1 in Seropositive Rheumatoids

Feb 12, 2019

Analyses from the Swedish EIRA incident rheumatoid arthritis cohort study shows that smoking and HLA-DRB1 exert differential effects on serologically defined RA subsets - but that the strongest influence was seen in double positive (CCP+, RF+) individuals.

These investigators have

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Ten Contemporary Challenges Facing Lupus Treatment

Feb 11, 2019

A group of French researchers have pooled their interests to identify the challenges ahead in the management of patients with systemic lupus erythematosus (SLE). 

This introspective review puts forth the authors’ perceptions of the 10 most important contemporary challenges in the

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Genetic Diagnosis for Previously Undiagnosed Disorders

Dec 11, 2018

The NEJM has reported the NIH's Undiagnosed Diseases Network (UDN) study results of genetically identifying new diseases from prospectively followed persons with undiagnosed disorders.

The UDN was formed in 2014 as a network of seven clinical sites, two sequencing cores, a coordinating center

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RheumNow Podcast – Can RA Be Prevented (12.7.18)

Dec 07, 2018

Dr. Jack Cush reviews the news and new journal articles from the past week on

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It's the Genes, Not the Diet that Raises Urate

Oct 18, 2018

Researchers from New Zealand find that in contrast with genetic contributions, diet explains very little variation in serum urate levels in the general population.

A total of 16,760 adults of European ancestry from the US were included in analyses. They were without kidney disease or

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The RheumNow Week in Review – No Good Gout (8.10.18)

Aug 10, 2018

Dr. Jack Cush reviews the news and latest journal articles from the past week on Info on Surgery and Hip Fractures, Gout drugs abandoned, Allopurinol escalation, hydroxychloroquine drug levels, how to treat scleroderma in India and exactly who gets back pain.

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Selective Use of HLA-B*5801 Testing in Gout

Aug 07, 2018

The current edition of JAMA Internal Medicine describes an Asian gout patient who presents with an allopurinol hypersensitivity reaction that could have been diagnosed by testing for HLA-B*5801.

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Epigenetic Link in Rheumatoid Arthritis to Huntington's Disease

May 15, 2018

Researchers at University of California San Diego School and the Icahn School of Medicine have found a high-resolution epigenomic landscape of rheumatoid arthritis (RA) that overlaps with that seen in Huntington's disease, suggesting potentially new unanticipated pathways that could be

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The RheumNow Week in Review – Why Comorbidity is Like the Weather (5.3.18)

May 04, 2018

Dr. Jack Cush discusses the news and journal articles from the past week on

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Genetic Breakthrough in Systemic JIA

May 02, 2018

The identification of a genetic susceptibility locus for systemic juvenile idiopathic arthritis (sJIA) has important implications for treatment of this severe, poorly understood illness, researchers reported.

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Shared Epitope - Smoking Pathogenic Link Clarified

Apr 19, 2018

Proceedings of the National Academy of Sciences (PNAS) has published new research on the mechanistic link between the rheumatoid arthritis (RA) "shared epitope" (SE) risk alleles and environmental triggers such as cigarette smoke that leads to joint inflammation and bony destruction

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Precision Genetics Can Predict Methotrexate Non-Responders

Mar 29, 2018

Investigators from Glasgow and Oxford have identified changes in genomic architecture, represented by a chromosome conformation signature, that can predict nonresponse to methotrexate in early rheumatoid arthritis patients.

Recognizing that studies show 35–59% of RA patients do not

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