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Myositis

Best of 2025: ERS/EULAR guidelines for CTD-related interstitial lung disease

The European Respiratory Society (ERS) and European Alliance of Associations for Rheumatology (EULAR) have published clinical practice guidelines for the evaluation and management of connective tissue diseases (CTD) associated interstitial lung disease (ILD) in two simultaneous publications in

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Best of 2025: Dermatomyositis Reviewed Researchers from the University of Pennsylvania have published an open-access review of dermatomyositis (DM) - its manifestations, hallmark cutaneous features, etiopathogenesis and treatment options. https://t.co/0vDvqIcj6U https://t.co/ogPjPI5gJa
Dr. John Cush @RheumNow( View Tweet )
Is the term polymyositis obsolete?.. now being replaced by dermatomyositis, necrotizing myopathy, inclusion body myositis, antisynthetase syndrome & overlap myositis. Full read overview of inflammatory myositis & new treatments from Joint Bone & Spine https://t.co/X46sptp1Ax https://t.co/M80026Z3Ur
Dr. John Cush @RheumNow( View Tweet )

Best of 2025: Dermatomyositis Reviewed

Researchers from the University of Pennsylvania have published an open-access review of dermatomyositis (DM) - its manifestations, hallmark cutaneous features, etiopathogenesis and treatment options.

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APPs in the news (12.5.2025) Dr. Jack Cush reviews the news and journal reports from https://t.co/V10S4oVFsv, including info on scleroderma, dermatomyositis and malignancy, rheumatologist and APP salaries concerns. https://t.co/znsjhTqTEv https://t.co/F0eu5w232C
Dr. John Cush @RheumNow( View Tweet )

APPs in the News (12.5.2025)

Dr. Jack Cush reviews the news and journal reports from RheumNow.com, including info on scleroderma, dermatomyositis and malignancy, rheumatologist and APP salary concerns.

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Scandinavian study of > 13.6 million PYs shows NO increased risk of myositis after SARS-CoV-2 (mRNA & adenoviral vector) vaccines. Data from 101 myositis events in 7,002 398 unvaccinated PYs. Adj IRR 180d risk was 0.84 (0.63–1.11) and 1.31 (0.72–2.36) respectively https://t.co/D5KVyvXaot
Dr. John Cush @RheumNow( View Tweet )
Retrospective study of 39 pts w/ MDA5 + DM-ILD Rx w baricitinib. 31 (79.5%) had improvement in Gottron’s, heliotrope, dyspnea, HRCT score, ferritin, LDH, steroid dose & 6 mo survival (87% vs. 70%, p = 0.047). https://t.co/RCTbBsCkeV https://t.co/dF8I0gF4Dy
Dr. John Cush @RheumNow( View Tweet )

Turkey Tryptophan (11.28.2025)

Dr. Jack Cush reviews the news and reports from this past week on RheumNow.com, including reports on FDA resurrections, FM seasonal worsening, and do you fight switch or swap biologics in PsA TNFi nonresponders?

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Retrospective study of 39 pts w/ MDA5 + DM-ILD Rx w baricitinib. 31 (79.5%) had improvement in Gottron’s, heliotrope, dyspnea, HRCT score, ferritin, LDH, steroid dose & 6 mo survival (87% vs. 70%, p = 0.047). https://t.co/RCTbBsCkeV https://t.co/K49cEmeRk3
Dr. John Cush @RheumNow( View Tweet )
Retrospective study of 39 pts w/ MDA5 + DM-ILD Rx w baricitinib. 31 (79.5%) had improvement in Gottron’s, heliotrope, dyspnea, HRCT score, ferritin, LDH, steroid dose & 6 mo survival (87% vs. 70%, p = 0.047). https://t.co/8whN2I1hXh https://t.co/voSVzPQWUI
Dr. John Cush @RheumNow( View Tweet )

Pulse Steroids and Mycophenolate in Juvenile Dermatomyositis

JAMA Dermatology has published a pilot study demonstrating the safety and efficacy of intermittent intravenous methylprednisolone pulse (IVMP) therapy plus mycophenolate in 28 patients with juvenile dermatomyositis (JDM).

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Treating During Pregnancy (11.14.2025)

Dr. Jack Cush reviews the journal articles, news and guidelines from this past week on RheumNow.com

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Hospital Mortality in Dermatomyositis

A cohort study shows that hospitalized patients with dermatomyositis have higher in-hospital mortality in the presence of active rash, interstitial lung disease, and elevated neutrophil to lymphocyte ratio at admission.

Dermatomyositis (DM) has significiant

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#ACR25 Abstr#LB14 Promising therapy BMS-986353, a CD19 CAR-T in Severe Refractory Idiopathic Inflammatory Myopathies. 11/12 had evaluable data; muscle, skin and ILD improved. 1 x G2 CRS, 1 G3 ICANS. Longer FU needed and larger sample @RheumNow https://t.co/zAG23tAsbL

Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
#ACR25 Abstr#0773 Anti-MDA5 ab is assoc. with progressive DM-ILD. But MDA5 expression is also upregulated in IPF. Any new biomarker which can link these ILD? Measuring reactivity to MDA5 (aa 201-300) epitope peptide may help identify poor ILD prognostics (with/out DM) @RheumNow https://t.co/rziwihKfIr
Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
Immune-Mediated Necrotizing Myopathy @EleniTiniakou #ACR25 *Younger pts tend to have a more aggressive disease *IVIG and RTX can be considered first-line rx for anti-HMGCR and anti-SRP+, respectively *CYC and plasmapheresis may be options in cases of aggressive disease https://t.co/zWDX79gqlf
Rheumatology Quarterly @RheumQuarterly( View Tweet )

Eating Crow (10.10.2025)

Dr. Jack Cush reviews the news, FDA approvals, and journal articles. In this episode: HMGCR Abs, FDA approvals and Cush eats crow.

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Whole Body MRI for Arthritis

Whole-body MRI (wbMRI) reviews have increasingly appeared in the medical literature, owing to better scanners, faster imaging times and reduced costs. Used of such non-oncologic musculoskeletal imaging provides high-contrast resolution images of the entire body or selected regions screening,

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Associations in Rheumatology (10.3.2025)

Dr. Jack Cush reviews the news, journal reports and important associations in rheumatology from the past week on RheumNow.com.

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Retrospective study of 137 pts w/ Usual interstitial pneumonia (UIP) w/ myositis Abs testing. 11% MSA+. & more like to have autoimmune Dz, +ANA, +RF. MSA negativity predicted by these 4: neg RF, ANA <1:320, no hypergammaglobulinemia, no Raynaud's - specificity 100%, sensitivity https://t.co/JAca1fpwZT
Dr. John Cush @RheumNow( View Tweet )

Challenges diagnosing lung disease and ILD in pediatric patients

Children with juvenile idiopathic inflammatory myositis (JIIM) are at risk of developing lung disease, notably interstitial lung disease (ILD). ILD can be asymptomatic initially, progressing silently to irreversible lung damage, which underscores the importance of early detection

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High-Resolution CT in CTD-Interstitial Lung Disease

A systematic review and meta-analysis examined the role of high-resolution computed tomography (HRCT) in diagnosing and characterizing interstitial lung disease (ILD) associated with connective tissue diseases (CTDs). The study analyzed 23 studies published between 2015-2024,

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When Myositis Hits the Lungs: What Every Rheumatologist Should Know About ILD

When idiopathic inflammatory myopathies (IIM) affect the lungs, the consequences can be serious. ILD is not only common in IIM, but also one of the leading causes of death, contributing to up to 80% of mortality in this patient group. For rheumatologists, two subsets stand out: anti-synthetase

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RheumNow Podcast – Ro, Ro, Ro52 (9.12.2025)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Are there benefits to diet or vegan diets? What's the effect of menopause on CTD?  Ro52 makes a big entrance with all our ILD coverage this month.

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