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CV Risks Raised in Myopathies

Jul 02, 2020

Patients with the idiopathic inflammatory myopathies (IIMs) dermatomyositis and polymyositis are at increased risk for cardiovascular events, with risks similar to what has been documented for rheumatoid arthritis (RA), during the first 5 years after diagnosis, U.K. researchers reported.

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#EULAR2020 #op0169 US claims database analysis reveals that gout and DM make for a dangerous combination: significantly higher risk of amputations in pts with gout+DM at 0.77% as oppose to DM w/out gout 0.461% & gout w/out DM 0.162% @RheumNow

Olga Petryna DrPetryna ( View Tweet)

Jun 07, 2020
#EULAR2020 Recc for irAEs w/ICI: 1. GC's ok, goal<10 mg/d, any csDMARD, bDMARD (TNFi/IL-6),🚫ABT xcept life-threatening myositis 2. Myositis beware bulbar signs: dysphagia, dysarthria, dysphonia: stop ICIs,⬆️GC, IVIG/PE 3.
Jun 06, 2020

Lenabasum Encouraging in Systemic Sclerosis

Apr 30, 2020

The oral cannabinoid receptor type 2 (CB2) agonist lenabasum showed promising results for systemic sclerosis (SSc) in a phase II study.

At week 16, the American College of Rheumatology Combined Response Index in diffuse cutaneous Systemic Sclerosis (CRISS) increased to 0.33 among

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RheumNow Podcast- 2019 EULAR RA Guidelines (1.31.20)

Jan 31, 2020

Dr. Jack Cush reviews the news and journal articles from the past week on

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Treatment of Statin-induced anti-HMGCR myopathy

Jan 10, 2020

Statin-induced myositis, often with anti-HMGCR autoantibodies can be difficult to manage, Arthritis Research & Therapy yhas published the experience of 55 patient with HMGCR myopathy, demonstrating that while steroid management may be reasonable in select patients, the use of

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ACR 2018 - Day 3 Report

Jan 09, 2020

Highlights from Tuesday, day 3 of the ACR Annual meeting in Chicago, included the PEXIVAS Study, ACR Reproductive Health Draft Guidelines, and a Proof of concept study

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RheumNow Podcast – Women Take Over Rheumatology (10.4.19)

Oct 04, 2019

Dr. Jack Cush reviews the News and Journal Reports from this week on

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Persistent Inflammatory Arthritis After Immune Checkpoint Inhibitors

Sep 23, 2019

Braaten and colleagues from Johns Hopkins School of Medicine have reported their experience with chronic inflammatory arthritis induced by immune checkpoint inhibitor therapies, showing that in some, inflammatory arthritis persists after the immunotherapy has been discontinued.

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Checkpoint Inhibitors: Who Gets Myocarditis?

Aug 28, 2019

The usual risk factors for myocarditis may not apply to who gets it while on immune checkpoint inhibiting cancer drugs, an FDA adverse event database suggested.

Myocarditis associated with immune checkpoint inhibitors (ICIs) was nearly twice as likely in women (OR 1.92, 95% CI 1.24-2.97

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RheumNow Podcast – Upadacitinib FDA Approved for RA (8.23.19)

Aug 23, 2019

Dr. Jack Cush reports on the news and journal reports from the past week on, including: how your genetics may shape your microbiome; GERD as a risk factor for TMJ?; how can MDA-5+ dermatomyositis be any worse; new drug happenings;; and more.

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RheumNow Podcast – More Than a Spot of Tea (8.2.19)

Aug 02, 2019

Dr. Jack Cush reviews the journal articles and news reports from the past week on
MMP-7 and Myositis-ILD; Post-surgical gout attacks; CV events and testosterone; and a Boxed warning for tofacitinib.

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RheumNow Podcast – Don’t Take My Advice (7.19.19)

Jul 19, 2019

Dr. Jack Cush reports the news and new journal articles from the past week on

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Predictors of Serious Infections with Rituximab

May 28, 2019

The risk of serious infectious events (SIE) with rituximab (RTX) is similar to that seen in other biologics (e.g., RA: 2% or 4.3/100PY), but with prolonged use the risk may change. Recent research says that low IgG levels, RTX induced neutropenia, prior SIE and comorbidities can significantly

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RheumNow Podcast – Richer or Poorer (5.17.19)

May 17, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on

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RheumNow Podcast – Periodontitis in RA Relatives (5.10.19)

May 10, 2019

Dr. Jack Cush reviews the news and journal articles from the past week on

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Calcineurin Inhibitors in Anti-Synthetase Dermatomyositis ILD

May 09, 2019

A pilot treatment study of patients with anti-aminoacyl-tRNA synthetase antibody–positive polymyositis/dermatomyositis-associated interstitial lung disease (anti-ARS-PM/DM-ILD) shows therapy with glucocorticoids and calcineurin inhibitors (CNI) to be highly effective. 

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No Rise in Cancer Risk with Actemra

Mar 18, 2019

In patients with rheumatoid arthritis (RA), there was no increased risk for malignancy development seen with newly initiated tocilizumab (Actemra) treatment, an analysis of three U.S. insurance claim databases found.

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RheumNow Podcast – You Owe Me a DEXA (3.15.19)

Mar 15, 2019

Dr. Jack Cush reviews this week's news and highlights from

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Brazilian Guidelines for Systemic Autoimmune Myopathies

Mar 14, 2019

The Myopathy Committee of the Brazilian Society of Rheumatology (BSR) has put forward recommendations for the management of patients with systemic autoimmune myopathies (SAM).

The challenge has been that there is a paucity of effective controlled clinical trials, and hence,

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RheumNow Podcast – Scleroderma and the Lung (3.1.19)

Mar 01, 2019

Dr. Jack Cush Reviews the news and journal articles from the past week on

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RheumNow Podcast - Scurvy and Mechanics (2-1-19)

Feb 01, 2019

Dr. Jack Cush reviews new journal articles, news reports, and more from the past week on

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Early Predictive Factors for Scleroderma Renal Crisis

Jan 14, 2019

It has been historically said that risk factors for scleroderma renal crisis (SRC) includes include cold exposure, steroid use, dehydration, rapid progression of skin disease, tendon friction rubs, anti-RNA polymerase III antibodies and pregnancy.  A new study examines risk factor for SRC at

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RheumNow Podcast – Rheumatologist Salaries (12.21.18)

Dec 21, 2018

Dr. Jack Cush reviews the news from RheumNow for the week ending 12/21/18.

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Nailfold Videocapillaroscopy in Dermatomyositis

Dec 19, 2018

A study of nailfold videocapillaroscopy (NVC) in patients with idiopathic inflammatory myopathies (IIMs) finds abnormalities in more than half of patients suggesting this could be a useful clinical tool in diagnosing and managing patients with IIM. 

A prospective study of 70 consecutive

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