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Pregnancy

Danish registries study shows maternal Autoimmune Dzs (all) were assoc w/ incr risk of childhood cancers (OR=1.25, 95% CI 1.06, 1.47), acute lymphoblastic leukemia (OR =1.52), Burkitt lymphoma (OR=2.6) & CNS tumors (OR=1.45); same seen for RA mothers https://t.co/HQO972ch9R https://t.co/dDEJUo8unq
Dr. John Cush @RheumNow( View Tweet )
Feb 10, 2024

Autoimmune disease and pregnancy

EurekAlert!
Feb 02, 2024

 For many aspiring mothers with autoimmune disease, pregnancy can be daunting and full of unknowns. In some cases, those suffering from specific autoimmune conditions have chosen to forego pregnancy altogether due to concerns about their disease treatments and adverse pregnancy outcomes.

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Very insightful talk on Vasculitis and pregnancy by Catherine Sims. Pregnancy compatible medications. Remission state. Checking antibodies ; risk of transmission, pregnancy and fetal morbidity. #RNL2024 @RheumNow https://t.co/81NAN1ulO5
Nouf Al hemmadi @NoufAhmedAlham2( View Tweet )
Jan 28, 2024
@drcassysims recommends @NIH resource: https://t.co/ebtvc2zYbE to guide lactation- updated and run by pharmacists. #RNL2024 @rheumnow

TheDaoIndex @KDAO2011( View Tweet )

Jan 28, 2024
MTX and cyclophosphamide are the two drugs @DrCassySims recommends holding during breast feeding in our vasculitis patients. #RNL2024 @RheumNow

Dr. Rachel Tate @uptoTate( View Tweet )

Jan 28, 2024
@DrCassySims checks APS ab on ALL pregnant (vasculitis) patients. "HCQ decreases neonatal lupus risk by half, meaning great reward for little risk." CS at #RNL2024 @RheumNow

Dr. Rachel Tate @uptoTate( View Tweet )

Jan 28, 2024
Nipple Raynaud's is an issue for some women with rheumatic diseases that occurs during breastfeeding and can be very painful @DrCassySims #RNL2024 @rheumnow https://t.co/HbaRpUnEBF

TheDaoIndex @KDAO2011( View Tweet )

Jan 28, 2024
High risk medications for pregnancy: MTX- 40% pregnancy loss, 6-10% birth defects MMF/CYC - 40% pregnancy loss, 25% birth defects Recommend 2 forms contraception on MMF Change meds slowly to safe Rx and monitor disease activity at least 3 mos before pregnancy #RNL2024 @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Jan 28, 2024
@DrCassySims noted if pts get accidentally pregnant on Methotrexate, stop med and give high dose folic acid 5 mg/d and alert high risk OB/MFM #RNL2024 @RheumNow #ReproductiveRheum https://t.co/DFiwaTiHVf
TheDaoIndex @KDAO2011( View Tweet )
Jan 28, 2024
Clinical Pearl! @DrCassySims currently treats with ASA 81mg po daily during vasculitis pregnancies at 12 weeks for preeclampsia ppx. She notes there is some data/use of 162mg po daily in Europe which may change the way we practice in the future. #RNL2024 @RheumNow

Dr. Rachel Tate @uptoTate( View Tweet )

Jan 28, 2024
We can do our best to optimize them for the best possible pregnancy outcomes? 1. Confirm pregnancy goals/timeline 2. Discuss patient’s disease activity over the past 12 mo 3. Document end organ damage and the last time this was assessed 4. Review medications 5. Check… https://t.co/7xQsGW9dKa

Dr. Rachel Tate @uptoTate( View Tweet )

Jan 28, 2024
"The most successful pregnancies are planned during periods of well controlled disease on pregnancy compatible medications." Dr. C Sims #RNL2024 @RheumNow @DrCassySims

Dr. Rachel Tate @uptoTate( View Tweet )

Jan 28, 2024
Rheumatology drugs in pregnancy. Just missing leflunomide in that big no no section @DrCassySims @RheumNow #RNL2024 https://t.co/ZPtTGRqPki
Richard Conway @RichardPAConway( View Tweet )
Jan 28, 2024
@DrCassySims: the Pregnancy Checklist for #Vasculitis patients @rheumnow #RNL2024 #ReproductiveRheumatology 👉confirm pregnancy goals 👉review meds, dz activity in the last 12 months 👉document end organ damage 👉assess Ro/La 👉discuss role of ASA 👉work w/ MFM/subspecialists https://t.co/5z4XeMRzGI
TheDaoIndex @KDAO2011( View Tweet )
Jan 28, 2024
Pregnancy in vasculitis checklist: - goals and timeline - disease activity in 12 mos - is there end organ damage? - Review Rx - h/o clots/miscarriages, APLS? - Check Ro/La - Role for ASA? - Refer to MFM Catherine Sims #RNL2024 @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Jan 28, 2024
How do vasculitis pts do during pregnancy? Variable due to different diagnoses of flares Gatto 2012: TA 3% flare, GPA 45% flare Fredi 2015: 35% flare Nguyen 2021: LVV 25% flare, 36% SVV -Catherine Sims #RNL2024 @RheumNow

Eric Dein @ericdeinmd( View Tweet )

Jan 28, 2024
Dr. A. Armstrong's Key Takeaways for PsO. TNFi - great in PsA and pregnancy IL-17i - robust PsO efficacy and in PsA IL-23i - robust in PsO, fewer injections, and efficacious in PsA. #RNL2024 @RheumNow @_AprilArmstrong https://t.co/j8LaOGITuf
Dr. Rachel Tate @uptoTate( View Tweet )
Jan 27, 2024
QD Clinic - Suspend MTX How Long? Pregnancy and MTX - how long do you have to be off? https://t.co/pTz8nlHpWN https://t.co/YrG7cKgbvF
Dr. John Cush @RheumNow( View Tweet )
Jan 18, 2024

Fertility and Rheumatoid Onset

MedPage Today
Jan 17, 2024

British women whose capability of bearing children either started late or ended early -- naturally or otherwise -- were at increased risk for developing rheumatoid arthritis (RA), compared with women with earlier menarche or later menopause, researchers found.



In an analysis of more

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Bidirectional relationship betw Autoimmune disease (AD) & perinatal depression (PND); 1:10 case control study of 1.3 milion pregnancies & 55,299 incident PND found AD preg w/ a 30% (OR 1.3) higher risk of PND & PND had a 30% ^ risk (OR 1.3) of AD https://t.co/zkwIo6liC7 https://t.co/Sy1HPLLeva
Dr. John Cush @RheumNow( View Tweet )
Jan 14, 2024

Best of 2023: 25 Great Women in Rheumatology

Dec 19, 2023

This week I reached out to many leaders in rheumatology and asked: who are the great women in rheumatology who should be recognized? This was prompted by a smart article in Annals of Rheumatic Disease written by Drs. Tuhina Neogi (Boston) and Nicola Dalbeth (N. Zealand), entitled "Where are the

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ICYMI: Maintain Vigilance for CV Risk Postpartum in Autoimmune Diseases

Pregnant women with autoimmune rheumatic diseases (ARDs) and antiphospholipid syndrome (APS) face significantly increased risks of cardiovascular events (CVEs). This increased risk is often attributed to ARDs, its medications or comorbidities associated with it.

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ICYMI: How do we manage difficult discussions about pregnancy in RA?

Dec 06, 2023

Most rheumatologists know that it is important to get pregnancy planning right for women of childbearing age living with rheumatic diseases. That is easier said than done, though: the details are difficult, it is overwhelming for the patient, and the conversations are hard.

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ICYMI: Issues in AxSpA: Treatment Intensification, Pregnancy

Dec 01, 2023

A lot of interesting studies will be presented at the poster sessions on Sunday, November 12 and some of them address practical real-world issues such as treatment intensification and the impact of pregnancy on axSpA imaging. 

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#ACRbest Abstracts – Day 4

Nov 16, 2023

While there wasn’t much original new programming and research presented on the final day, that didn’t slow the RheumNow faculty from tweeting the noteworthy “Best of ACR” abstracts. Enjoy these below.

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