Pregnancy

Swedish Birth Registry study of adverse preg outcomes (APOs) after SSc Dx [n=941] or w/in 3 yrs [39] or > 3yrs pre-Dx [839]. SSc women have incr APOs post-Dx, including preeclampsia (RR 3.8), preterm (3.3), C-section (2.5); but also incr APO risk w/in 3 yrs of Dx

Dr. John Cush @RheumNow( View Tweet )

Systematic review of 10 studies showed TNFi exposure in utero not assoc w/ incr risk of infant severe infxn (4 RCTs); same for breast milk exposure (2 RCTs). Infant vaccination outcomes unaffected by TNFi use, but rec delaying BCG vaccination if TNFi exposed https://t.co/02Nn6TuzR3
Dr. John Cush @RheumNow( View Tweet )
Using AI and LLMs in Qualitative Data Dr. Bella Mehta discusses abstract 0794 (Using AI to Analyze Multilingual Qualitative Data in Lupus Pregnancy Research: A Proof of Concept with Large Language Models) presented at #ACR25 https://t.co/HFBuNxdZOF https://t.co/gKAXURq8xR

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Dr. John Cush @RheumNow( View Tweet )
Marketscan claims study of 62,813 IMID women w/ 70,529 pregnancies & 69,412 births, 4,485 (7.1%) were exposed to at least one TNFi during pregnancy & 3,559 postpartum. TNFi use NOT assoc w/ SIE risk during Preg (HR 1.39; 0.95-2.05) or postpartum (HR 1.22; https://t.co/NsxOLpT0ds
Dr. John Cush @RheumNow( View Tweet )
🍼 “Stop breastfeeding if on methotrexate” — that’s what we’ve always heard. But here’s the news 👇 📊 Latest EULAR lactation: Methotrexate = LoE 4 / C ➡️ May be considered in breastfeeding if no safer alternative exists. 💡Not first-line, not forbidden — just evidence-limited. https://t.co/IJEpZYMaFV

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Dr Abhilasha Manwatkar (AIIMS Nagpur) @Abhilasha21822( View Tweet )
Really great visual summaries by Athena Chin, Sam Whittle and colleagues: Recs for the Use DMARDs in Pregnancy and Reproductive Health for Pts w Rheumatic Disease: A Scoping Review - Oct 2025 - Arthritis Care & Research #Rheumatology #MedEdu https://t.co/zRJcTESJWN 🇦🇺 https://t.co/OYZVtLEYr7

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Suleman Bhana, MD @DrBhana( View Tweet )
New Insights into Pregnancy Outcomes and Maternal-Fetal Health in Rheumatic Diseases At #ACR25, the ACR presented new research illuminating critical challenges and advances in pregnancy outcomes for women living with rheumatic diseases, including axial spondyloarthritis, https://t.co/nJjtTMHnD3
Dr. John Cush @RheumNow( View Tweet )
Abstract 2360: Single-center lupus pregnancy cohort found that: 🔹 Absence of DORIS remission associated w/ adverse pregnancy outcomes (Pre-term, Pre-eclampsia) 🔹 This is along with known risk factors: antihypertensive use, prior nephritis, active disease @RheumNow #ACR25 https://t.co/STg1NBeFPo

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Akhil Sood MD, MS @AkhilSoodMD( View Tweet )
Reaadmissions in sle pregnancies from 66k patients Insurance and economics seem to be very important in predictions using machine learning. Abst#2629 #ACR25 @RheumNow https://t.co/x2oo9TOxoh

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Bella Mehta @bella_mehta( View Tweet )
In healthy women, preeclampsia was more common with: - increased calprotectin - decreased anti-CCP (very low levels) during pregnancy & this has good predictive capacity for future preeclampsia. Rheum pathophys can give insights into adjacent pathology #ACR25 ABST2628 @RheumNow https://t.co/7d5YB6n6XJ

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David Liew @drdavidliew( View Tweet )
Anti ccp may be protective for preeclampsia (secondary to NETs) Abst#2628 @RheumNow #ACR25 https://t.co/n3ge0iIiB0

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Bella Mehta @bella_mehta( View Tweet )
DMARD exposure overall during pregnancy is not associated with severe maternal or neonatal morbidity, in this Ontario cohort. We’re getting better at finding a balance with DMARDs that is safe for both mother and baby. Blanket resistance is harmful #ACR25 ABST2627 @RheumNow https://t.co/oDOpySGS3N

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David Liew @drdavidliew( View Tweet )
Large Canada ICES dataset- DMARD use is not associated with adverse pregnancy outcomes. In pts with RA, SlE and other rheumatic diseases. Abst#2627 #ACR25 @RheumNow https://t.co/T9Ll1FNjT7

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Bella Mehta @bella_mehta( View Tweet )
This cohort study from Ontario of 🚺w/axSpA ✳️GDM, antepartum hem, SMM (severe maternal morbidity) -⬆️ in axSpA ✳️Neonat complications-preterm birth Factors assoc w/SMM- age, comorbidity, gestational age at delivery Better strategies for maternal care #ACR25 @RheumNow Abs2200 https://t.co/LrVzJLnvWe

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sheila @RHEUMarampa( View Tweet )
#ACR25 Abstr#0855 Five extra patients were added to complete IMPACT Open Label Phase 2 trial of add-on Certolizumab in APS women + LAC+ve. Results stood: primary endpoint was met (adverse pregnancy outcome=19.6%; lower than 20% expected). Significant enough to adopt @RheumNow https://t.co/zhFVGYXiaU

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
A largely understudied area: Impact of peri-menopause in PsA Toronto Cohort 473pts, HRT 1.5% Peri menopause = increase DAPSA, TJC, SJC, FACIT-fatigue, HAQ compared to pre- and post-menopause No association w/ BMI, but with fatigue Less impact when education level increases https://t.co/bSuGxZCbGn

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Aurelie Najm @AurelieRheumo( View Tweet )
In the IMPACT trial (Abs 0855), certolizumab met its primary endpoint: <20% had an adverse pregnancy outcome (APO) among females w/ APS & prior APO. ✅ 94% live births, all survived to discharge 📈 Median GA: 37 wks (no APO) vs 31 wks (APO) @RheumNow #ACR25

Akhil Sood MD, MS @AkhilSoodMD( View Tweet )

Pregnancy risk in Sjögren’s & scleroderma Meta-analysis (n=4,820) shows ↑ risk of miscarriage in Sjögren’s (RR 1.8) & ↑ preterm birth in SSc (RR 2.4). Calls for preconception counseling & multidisciplinary high-risk OB care. @RheumNow #ACR25 Abstract #1398

Jiha Lee @JihaRheum( View Tweet )

#0853 Olink proteomics in anti-Ro+ pregnancies identifies macrophage-derived IL-6 & CCL3 as serum predictors of foetal AV block These pro-inflammatory proteins predicted fAVB independent of maternal diagnosis or Ab titres, pointing to new pathogenic pathways. @RheumNow #ACR25

Mrinalini Dey @DrMiniDey( View Tweet )

#0793 In #SLE, abusive trauma was linked to 58% higher risk of medication non-adherence; resilience buffered this effect. Patients with trauma cited motivational, not access-related, barriers. Trauma-informed & resilience-focused care may improve adherence. @RheumNow #ACR25

Mrinalini Dey @DrMiniDey( View Tweet )

#0794 LLMs can accelerate qualitative lupus pregnancy research. Using AI to translate & analyze interviews from Portuguese, GPT-4 achieved top accuracy & coherence vs human themes. LLMs may expand inclusion & equity in rheum research. @RheumNow #ACR25 https://t.co/TAxg6Qyk0L

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Mrinalini Dey @DrMiniDey( View Tweet )
For #SLE pleuropericarditis: recommendation intentionally tries to leverage use of colchicine/NSAIDs vs. GCs But there are special situations where GCs are req’d: > Concomitant active SLE > CI to NSAIDs/Col > Recurrent pericarditis > Late pregnancy > 💊interxns #ACR25 @RheumNow https://t.co/sLL72t3Qhf

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sheila @RHEUMarampa( View Tweet )
pregnant, pregnancy, mother, fertility

New Insights into Pregnancy Outcomes and Maternal-Fetal Health in Rheumatic Diseases

ACR Press Release

At ACR Convergence 2025, the American College of Rheumatology presents new research illuminating critical challenges and advances in pregnancy outcomes for women living with rheumatic diseases, including axial spondyloarthritis, antiphospholipid syndrome, and lupus. These studies offer

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Bad Actor Cofactor (10.17.2025) Dr. Jack Cush reviews the news and journal reports, discusses pediatric reports, pregnancy data, diet and nutrition and more https://t.co/zDDLwwRSy9 https://t.co/2S8jPOY0Be

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Dr. John Cush @RheumNow( View Tweet )
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Bad Actor Cofactor (10.17.2025)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports, discusses pediatric reports, pregnancy data, diet and nutrition and more.

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Still’s disease and autoinflammatory disorders are rare conditions unified by recurrent fevers and inflammation of skin, joints, and other organs. While labs often support the diagnosis, these conditions are best diagnosed by genetic testing, or by specific criteria (in the absence of a genetic test). The following is a table that lists common misconceptions (myths) and their clarifying explanations. Read Post
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