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Pregnancy

Infertility linked to post-childbrith onset of systemic autoimmune disease Women who experience infertility but do not use fertility treatments have a higher risk of developing a group of conditions called systemic autoimmune rheumatic diseases (SARD) in the nine years after a… https://t.co/NJf44KJ2Hc https://t.co/W4rhsDHoqB
Dr. John Cush @RheumNow( View Tweet )

Infertility linked to post-childbrith onset of systemic autoimmune disease

EurekAlert!

Women who experience infertility but do not use fertility treatments have a higher risk of developing a group of conditions called systemic autoimmune rheumatic diseases (SARD) in the nine years after a naturally conceived birth compared to women without fertility problems.

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Treat-to-Target Improves Fertility in Women with RA https://t.co/q9IMI5UHGO https://t.co/uhqaRXeBRX
Dr. John Cush @RheumNow( View Tweet )

ICYMI: Reproductive Issues in axSpA: Fertility and Pregnancy

Axial spondyloarthritis (axSpA) affects young patients with symptom onset occurring in early adulthood. Apart from pain and quality of life, reproductive issues also arise because patients who are diagnosed with the disease are also in their reproductive age. Two interesting abstracts about

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Improving fertility in women with RA For women with rheumatoid arthritis (RA), the journey to motherhood brings unique challenges, such as longer times to conception and infertility rates twice as high as those without RA. Factors like high disease activity, regular use of… https://t.co/9QXgeB7ftB https://t.co/mVUabSdLNE
Dr. John Cush @RheumNow( View Tweet )
Treat-to-Target Improves Fertility in Women with RA Dr. Richard Conway discusses abstract 1647, presented at #ACR24 https://t.co/vC0CA0lN4M https://t.co/Dfo7iBYwcU
Dr. John Cush @RheumNow( View Tweet )

Improving fertility in women with RA

For many women, the journey to motherhood brings a sense of anticipation and joy. However, for those with rheumatoid arthritis, this journey presents unique challenges. At ACR Convergence 2024, researchers discussed how advancements in reproductive medicine and RA management are paving the way

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Is Pregnancy Truly the Solution for RA? Pregnancy is perhaps the oldest treatment in rheumatoid arthritis (RA) and has been associated with a natural improvement in disease control in 50-75% of patients. Others, however, are not as successful with unchanged disease activity or… https://t.co/MesVIUl0fC https://t.co/760i5znmeu
Dr. John Cush @RheumNow( View Tweet )
Reproductive Issues in axSpA: Fertility and Pregnancy axSpA affects young patients with symptom onset occurring in early adulthood. Apart from pain and quality of life, reproductive issues also arise because patients who are diagnosed with the disease are also in their… https://t.co/8tLFOvFqdO https://t.co/E3AOOCHTgu
Dr. John Cush @RheumNow( View Tweet )
If a mother has had TNFi during pregnancy, can a baby have a live oral rotavirus vaccine (usually at 2mo)? This claims data suggests no increase in diarrhoea Adds to similarly reassuring 🇨🇦prospective cohort data https://t.co/2Tz9zRhPjz Vaccinate away! #ACR24 ABST0806 @RheumNow https://t.co/66OIAR8W6l
David Liew @drdavidliew( View Tweet )
Nice data from the OTIS Autoimmune Disease in Pregnancy Project re: certolizumab-exposed pregnancies: - spontaneous loss rate comparable to non-disease controls - no stillbirths - preterm similar to disease controls Plenty positive for CZP in pregnancy! #ACR24 ABST0805 @RheumNow https://t.co/XCRYsioxC0
David Liew @drdavidliew( View Tweet )
A key practice changing study (I hope) from #ACR24 has been the preCARA study. Fertility increases with aggressive disease control. My video on this study is up now on @RheumNow https://t.co/Pf3rdTHbOJ

Richard Conway @RichardPAConway( View Tweet )

In this systematic review & metaanalyis by Dr. RFarhat et al, tacrolimus whole blood levels decrease in the 1st & 2nd trimesters then increase back to pre-pregnancy levels postpartum. Needs further studies to guide dose adjustment. @RheumNow #ACR24 abs1535 https://t.co/5MovzPJoFc
Study on pregnancy outcomes in SLE with thrombocytopenia: Higher disease activity, pregnancy loss, and stillbirth rates Identified risk factors: Anti-β2GP-I positivity and higher SLEDAI score #ACR24 abst#1487 @RheumNow

Bella Mehta @bella_mehta( View Tweet )

Quaack etlal. PreCARA study (vs PARA, historical control). T2T in RA improves fertility - time to pregnancy 84 days vs 196 days. T2T strategy also led to less NSAIDs and prednisolone. @RheumNow #ACR24 Abstr#1647 #ACRbest https://t.co/vYCCUqpCLo https://t.co/PUHJOxgGbL

Richard Conway @RichardPAConway( View Tweet )
Plenary II: pregnancy in RA When a treat to target approach is used to achieve remission, pregnancy rates nearly similar to general population! Time to pregnancy less than half that of non-T2T comparators @RheumNow #ACR24 https://t.co/B9F9M8t9Kt
Brian Jaros, MD @Dr_Brian_MD( View Tweet )
Improved fertility in women with RA when treated with a Treat-to-Target (T2T) approach aimed at remission. Key findings: - Shorter time to pregnancy (TTP) in PreCARA cohort (84 days) vs. PARA cohort (196 days). - Increased TNF-inhibitor use and lower NSAID/prednisone use in the… https://t.co/YyD2lpXVRC https://t.co/LH5LMOH8al
Antoni Chan MD (Prof) @synovialjoints( View Tweet )
Managing DMARDs in pregnancy. Curbside consults by Lisa Sammaritano @RheumNow #ACR24 https://t.co/FQrLNz4yCz
Antoni Chan MD (Prof) @synovialjoints( View Tweet )
The DESIR cohort of Dr. Franc et al. showed that female pts with early axSpA had significantly lower AMH levels vs. general population reflecting low ovarian reserve & fertility. Mechanism? Bigger studies need to be done @RheumNow #ACR24 abs577 https://t.co/842rX79bq6
Is it pre-eclampsia or lupus nephritis flare? Abstract 0809: The sFlt-1/PlGF ratio may help distinguish preeclampsia from lupus nephritis in pregnancy. A low ratio ruled out preeclampsia, while a high ratio ± proteinuria suggests increased risk. @RheumNow #ACR24

Akhil Sood MD @AkhilSoodMD( View Tweet )

Hamroun et al. Meta-analysis of glucocorticoids in pregnancy and breast-feeding. Increase pre-term birth with GCs, adjusted OR 2.24. Dose-dependent effect. Minimal breastmilk transfer. @RheumNow #ACR24 Abstr#0810 https://t.co/H0o9ElsHmc https://t.co/uciFP6UOhF
Richard Conway @RichardPAConway( View Tweet )
Abstract #0805 Data from OTIS Registry shows Certolizumab pegol (Cimzia) exposure during pregnancy was not associated with increased risk of major birth defects, structural defects, or adverse pregnancy outcomes. #ACR24 @RheumNow

Akhil Sood MD @AkhilSoodMD( View Tweet )

Contraception counselling in #SLE post intervention - Contraceptive counseling rates improved from 33.9% to 55.7% - Women over 35 were 4.09 times more likely post-intervention - Non-Hispanic Black women were less likely than Hispanic women #ACR24 abst#0184 @RheumNow https://t.co/sOZXnAe4ov
Bella Mehta @bella_mehta( View Tweet )

Is Pregnancy Truly the Solution for RA?

Pregnancy is perhaps the oldest treatment in rheumatoid arthritis (RA) and has been associated with a natural improvement in disease control in 50-75% of patients. Others, however, are not as successful with unchanged disease activity or worsening of their autoimmune disease. An

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High serum BAFF as a novel RF for dev't of preeclampsia in pregnant SLE pts? This study by Dr. C Sims et al showed that SLE pregnancies w/preeclampsia had significantly higher BAFF levels during the 1st trimester, and likely w/ ⬆️dsDNA or ⬇️ complement @RheumNow #ACR24 abs424 https://t.co/kNzyuT03r2
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