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Pregnancy

IMPACT Study - Certolizumab Efficacy in APS Pregnancies A pilot trial assessed the safety and value of tumour necrosis factor α inhibitor treatment with certolizumab in patients with high-risk pregnancies with antiphospholipid syndrome (APS). Certolizumab (CZP) was shown to https://t.co/sbXW6vNX5y
Dr. John Cush @RheumNow( View Tweet )
MMWR: 1994 the U.S. Vaccines for Children program has covered the cost of vaccines for US children. Since 1994 routine child vaccinations will have prevented ~508 million illness, 32 million hospitalizations, & 1,129,000 deaths,; direct savings of $540 billion & societal savings https://t.co/JCeSFmIgxV
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Biologics in Pregnancy Patients With Autoimmune Disease A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients https://t.co/CH60gShlH0
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SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/z0BOT3xsuQ
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Lupus Unlocked: Pregnancy & SLE 📅 May 27, 2025 6:00 PM CT | 7:00 PM ET | 4PM PT Join us for our final Lupus Unlocked webinar this month on pregnancy and SLE. In this webinar, panelists will discuss issues such as congenital heart block, lupus nephritis treatment, teratogenic https://t.co/gouTN7uzCo
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controversy re 👇 Monitoring for +Ro pregnant re #congenital #heart #block 87% Y echo is possibly too late No ideas if flourinated #steroids work But many thing we should do something Guidelines differ on recommendations Would fetal home HR be better #LUPUS2025 @RheumNow https://t.co/MY0oPjLnGs
Janet Pope @Janetbirdope( View Tweet )

Diagnosing Neuropsychiatric SLE (5.23.2025)

Dr. Jack Cush reviews the news and journal reports from RheumNow.com - including views on the vagus nerve, NPSLE and CAR-T mania.

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do’s & don’t #Lupus #nephritis ❎ Don’t sequential monotherapy ▶️ use #MMF + #biologic or #CNI ✅ Do a #biopsy ➡️ need to know #dx #px Do target LOW proteinuria Do treat comorbidities Lipids HTN Fluids BMI ?mood No #NSAIDs Do limit #pred #SGLT2i @RheumNow #LUPUS2025 https://t.co/D0vHQXYTvZ
Janet Pope @Janetbirdope( View Tweet )
Steroids prevention of #congenital #heart #block in +Ro Mom #DM #HTN #wt⬆️ Fetus ?no diff #cardiomyopathy ?learning &behavioural changes Debate re screen #CHB Most CHB are kids w CHB as mom is unknown to be +Ro Angst w screening High titre Ro Impt @RheumNow #LUPUS2025

Janet Pope @Janetbirdope( View Tweet )

Do you routinely recommend SLE +Ro/La pregnant Pts to have routine screening for #congenital #heart #block #LUPUS2025 @RheumNow

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‘To screen or not’? For #CHB #congenital #heart #block Great debate #LUPUS2025 In #pregnant women with #SLE In + #Ro #SSA &/or #La #SSB mothers CHB Rx - #flourinated #steroids To ⬇️#fetal #mortality ❎no benefit ⬇️#cardiomyopathy ❎ ⬇️#pacemaker ❎ ⁦@RheumNow⁩ ??🤷‍♀️ https://t.co/xauDzfNBsC
Janet Pope @Janetbirdope( View Tweet )
QD Clinic - Tackling Lupus Pregnancies Managing Lupus Pregnancy - pre-pregnancy, labs & safe drugs https://t.co/rtDVCCVqnD https://t.co/IRi1qYYqAA
Dr. John Cush @RheumNow( View Tweet )
SLE, Antiphospholipid Antibodies, and the Placenta It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications https://t.co/f8Up1112m9
Dr. John Cush @RheumNow( View Tweet )

Biologics in Pregnancy Patients With Autoimmune Disease

A large cohort, claims data study shows that among pregnant women receiving biologic therapies for autoimmune conditions, 72% continued their biologics pregnancy, more so among inflammatory bowel disease (IBD) patients than those with rheumatoid arthritis (RA), psoriasis (PsO) or psoriatic

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Comparing EULAR (2025) and ACR (2020) Guidelines on Safety of Lupus Medications in Pregnancy Attendees at the 2025 RheumaPreg meeting were excited to discuss the newly released EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation. https://t.co/csd0FE08ZO
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Clinical Impacts of the Pre Lupus State on Pregnancy Outcomes Dr. Catherine Sims talks with Dr. Jessica English at the RheumaPreg 2025 meeting in Vienna, Austria. https://t.co/T8ZYQtDNmZ https://t.co/PmVRFVlABd
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Lupus QD Clinic - SLE Get Ready Young SLE patient wants to get pregnant; but first she needs to get ready! Features Dr. Jack Cush https://t.co/988jrHmdUs https://t.co/qVrBU2lvI5
Dr. John Cush @RheumNow( View Tweet )

Panacea of Prednisone & Cannabis (5.16.2025)

Dr. Jack Cush reviews the news, journal and regulatory reports from this week on RheumNow.com.  Interesting trends and results with prednisone in lupus, cannabis in RA and opioid deaths too!

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SLE, Antiphospholipid Antibodies, and the Placenta

It is well established that women with SLE are at increased risk for adverse pregnancy outcomes, including preeclampsia, preterm birth, and pregnancy loss. However, the pathophysiologic mechanisms driving these complications are not yet fully understood. In this article, we explore several

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SLE trends: pulse methylprednisolone followed by low dose steroids is rec by various guidelines. Risk factors for SLE flare after GC withdrawal: high Dz activity, active serology, younger age, shorter remission duration, faster tapering strategy, shorter duration/cessation of https://t.co/g6LaTijOpA
Dr. John Cush @RheumNow( View Tweet )
Comparing EULAR (2025) and ACR (2020) Guidelines on Safety of Lupus Medications in Pregnancy Attendees at the 2025 RheumaPreg meeting were excited to discuss the newly released EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation. https://t.co/DSYPaElRij
Dr. John Cush @RheumNow( View Tweet )

Comparing EULAR (2025) and ACR (2020) Guidelines on Safety of Lupus Medications in Pregnancy

Attendees at the 2025 RheumaPreg meeting were excited to discuss the newly released EULAR recommendations for use of antirheumatic drugs in reproduction, pregnancy, and lactation. Table 1 summarizes the major recommendations from EULAR (2025) and the American College of Rheumatology (2020)

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Certolizumab effective in preventing adverse pregnancy outcomes in high-risk antiphospholipid syndrome. CZP given to 51 APS pts wks 8 to 28. 9 w/ primary APO (17.6%) (6 w/ pregnancy loss <10 wks) - significantly lower than historical controls. Median delivery 36.5 wks. Neonatal https://t.co/KfOOM7sEAt
Dr. John Cush @RheumNow( View Tweet )

Vitamin D Headlines (5.9.2025)

Dr. Jack Cush reviews the news, journal reports and lupus highlights from the past week on RheumNow.com. Triple positivity, the gut and CRPS, and hope for better outcomes with Vitamin D therapy. 

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Stable SLE - Should you Withdraw Immunosuppressant or Glucocorticoids? An open-label, single-centre, randomized controlled trial tested whether immunosuppressant (IS) withdrawal is noninferior to glucocorticoid (GC) withdrawal in SLE patients and found that IS withdrawal is https://t.co/T8Fu83GScH
Dr. John Cush @RheumNow( View Tweet )
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