Pregnancy

Dr. John Cush Tweet
@RheumNow
Pregnancy After CAR-T in Autoimmune Disease: 14 Pregnancies, No Flares The first multicenter series of pregnancies after CAR T-cell therapy for autoimmune disease reports 8 healthy births and no maternal flares. It is the first dataset of its kind, and the numbers are small. https://t.co/uqWz8GeAmX
Dr. John Cush Tweet
@RheumNow
Menopause and Rheumatoid Arthritis: Are we asking enough? A study from Mayo Clinic at ACR Convergence, abstract 1849 examines menopause symptom burden in women with and without RA. Using two research datasets, Kristen Young and colleagues conducted a cross-sectional analysis of https://t.co/V3VJXo3z5w
Akhil Sood MD, MS Tweet
@AkhilSoodMD
Can adverse pregnancy outcomes predict SLE or RA? Abstract 2860 found: - Future SLE assoc. w/ hx of preeclampsia (aOR 1.89), emergency c-section (aOR 1.90), and short gestational duration (aOR 0.93) - Future RA assoc w high pre-pregnancy BMI (aOR 1.19) @RheumNow #ACR26
Akhil Sood MD, MS Tweet
@AkhilSoodMD
What drives delays in lupus diagnosis? Abstract 2748 found • After 2010, time to diagnosis 4.7 years (mean) • Older age, race (Am. indian/Alaska native), and specific sx. at onset (fatigue, pregnancy complications, heavy menstrual bleeding) linked to delay #ACR26 @RheumNow
Bella Mehta Tweet
@bella_mehta
Reproductive health counseling in SLE: interviews with 30 Hispanic women and 26 Rheums found differences. Pts viewed it as ongoing life planning; physicians discussed it reactively with active disease or teratogenic meds. Start early. Ask goals. #ACR26 @rheumnow Abstract #1713
Article

Lupus Nephritis Reshapes Pregnancy Risk

Bella Mehta, MBBS, MS

Investigators presented an abstract using Epic Cosmos to examine pregnancy outcomes in women with SLE across health systems nationwide. Beyond confirming that SLE pregnancies remain higher risk, the study highlights two important opportunities: the ability to use large-scale, real-world data to

Akhil Sood MD, MS Tweet
@AkhilSoodMD
Do women w RA have more severe menopause symptoms? Abstract 1849: Mayo cohort that RA vs non-RA • Severe symptoms higher (72.1% vs 56.5%) • Greater odds of severe symptoms (OR 1.96, 95% CI 1.44-2.67) • Use of SSRI/SNRI or HRT similar in both groups #ACR26 @rheumnow
Akhil Sood MD, MS Tweet
@AkhilSoodMD
Does aPS-PT IgG predict adverse pregnancy outcomes in SLE? Abstract 1844 looked at 98 pregnancies in prospective LEGACY cohort. • APO risk: aPS-PT IgG > LAC > IgM (HR 8.5 > 5.1 > 1.5) • aPS-PT IgG comparable performance predicting APO vs LAC (AUC 0.77 vs 0.83) #ACR26 @rheumnow
Adela Castro Tweet
@AdelaCastro222
aPL vs APS in Pregnancy: Same Antibody, Different Plan -aPL but no APS: no anticoagulation; low-dose aspirin (LDASA) may reduce preeclampsia risk -Obstetric APS: LDASA + prophylactic LMWH, continued through 6 weeks postpartum -Thrombotic APS: LDASA + treatment-dose LMWH;
Adela Castro Tweet
@AdelaCastro222
-Biologic DMARDs are generally safe for pregnancy: ETA and CZP safer compared to others. -B cell depletion can be used in pregnancy but caution about neonatal cytopenias for first 6m if dosed in 2nd half og pregnancy. -Counsel on vaccination for biologic exposed babies. #ACR26 https://t.co/byQgPpAveT
Dr. John Cush Tweet
@RheumNow

Pregnancy in Lupus Nephritis and RA: Managing risks and treating to target A significant proportion of patients with rheumatologic disease are of reproductive age, therefore, navigating reproductive health is now widely recognized as a fundamental component of modern https://t.co/cTVvyXBbug

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