Difficult to treat RA (D2T-RA) study of 48 D2T-145 non-D2T-RA pts. D2T-RA was predicted by Not starting MTX w/in 3 mos (

Article Rheumatoid Arthritis

Difficult to Treat Rheumatoid Arthritis

Jack Cush, MD Jan 29, 2026

Dr. Cush addresses the management of difficult-to-treat rheumatoid arthritis (D2TRA).

Article Rheumatoid Arthritis

“ABCDE” Approach to Difficult-to-Treat Rheumatoid Arthritis

Jack Cush, MD Sep 2, 2026

The proposed approach to difficult-to-treat rheumatoid arthritis is based on the EULAR definition (having failed 2 or more b/tsDMARDs). The authors provide guidance in the form of an easy acronym, A B C D E, which covers both diagnostic and therapeutic considerations.

Article Rheumatoid Arthritis

The Concern about Seronegative RA

Jack Cush, MD Nov 3, 2026

A current review of seronegative RA (SNRA) by D’Onofrio, et al in npj Autoimmunity shows the diverse fate of seronegative RA - which can resolve, persist or become refractory. Clearly dedicated trials of SNRA are needed to better predict.