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‘Tis the Season for Vaccination

Eric Dein, MD

As the leaves start changing color and spooky decorations populate neighborhood doorsteps, another autumnal tradition begins: vaccination counseling. Fall offers a golden opportunity to protect our patients before respiratory viruses fill our waiting rooms. In patients with rheumatologic diseases, vaccinations can be confusing and worrisome. For clinicians with limited bandwidth, these conversations can feel like added responsibilities in an

Dr. John Cush
@RheumNow
Colchicine & Statins: A significant interaction? Colchicine is frequently used in rheumatologic practice. Current ACR guidelines for gout management support anti-inflammatory prophylaxis, including colchicine, during initiation and uptitration of urate-lowering therapy https://t.co/BFF9UTuLIl
Dr. John Cush
@RheumNow
Single center study of Probiotics in #PsA showed no benefit. 66 moderately active PsA pts (PASDAS>3.2) on stable Tx: Rx probiotic vs PBO x 12 wks. 56 pts analyzed, PASDAS <3 responders: 43% probiotic vs 65% PBO (P 0.167), w/ no change in gut permeability markers or stool https://t.co/0JUZ8SrRuw
Dr. John Cush
@RheumNow
92 early (<2 yrs) systemic sclerosis pts were treated with #MTX; 79% diffuse SSc. At 3 mos, 34% of dcSSc ≥25% reduction in mRSS - increasing to 612% a@ 24 mos (29% at 24 mos ITT w/ non-responder imputation). GC did not improve skin. Dz progression seen w/ 75% of MTX monoTx D/C https://t.co/w5Gc3ntej0
Dr. John Cush
@RheumNow
Can DMARD Doses Be Safely Reduced for RA Patients? Close to 90% of patients with rheumatoid arthritis (RA) well controlled on targeted therapies were able to take 50% dosage reductions without experiencing worsened disease activity in a randomized trial, South Korean https://t.co/MyjZdRaGb4
Dr. John Cush
@RheumNow
Colchicine & Statins: A significant interaction? Colchicine is frequently used in rheumatologic practice. Current ACR guidelines for gout management support anti-inflammatory prophylaxis, including colchicine, during initiation and uptitration of urate-lowering therapy https://t.co/eyDbfpQajN
Dr. John Cush
@RheumNow
Surgery for 1st MTP Osteoarthritis Hallux rigidus, or osteoarthritis of the first metatarsophalangeal joint (MTPJ), is common, but treatment options and long-term outcomes remain poorly understood. A 12-month clinical trial showed that first MTPJ arthrodesis (compared to https://t.co/fHda4GK4vA
Dr. John Cush
@RheumNow
Single center study of Probiotics in #PsA showed no benefit. 66 moderately active PsA pts (PASDAS>3.2) on stable Tx: Rx probiotic vs PBO x 12 wks. 56 pts analyzed, PASDAS <3 responders: 43% probiotic vs 65% PBO (P 0.167), w/ no change in gut permeability markers or stool https://t.co/g6icpjuQOU
Dr. John Cush
@RheumNow
UK survey study of 6607 autoimmune dz pts (91% female) saw females had longer Dx delays, more HCP visits, & signif more often told their Dz attributed to psychiatric (43% vs 33%: OR 1.56) or psychosomatic causes (34% vs 21%; OR 1.87). Females had slightly more misdiagnoses (48% https://t.co/tGhiWCSPy9
Dr. John Cush
@RheumNow
Study of Prognostic Nutritional Index (PNI) in 984 RA pts shows PNI is independently inversely corelated w/ RA dz activity, esp. PNI <45. PNI = ser albumin & lymphocyte count calculation (10 × s albumin [g/dL]) + (0.005 × lymphocyte count/mm³]). Other studies have shown modest https://t.co/AV3AGXwSfg
Dr. John Cush
@RheumNow
French National Health System study of 214,892 #RA pts (~40K on TNFi) found 562 demyelinating events (2008-2023) w/ cumulative 10 yr incidence of 0.32% w/ csDMARDs & 0.50% w/ TNFi (HR 1.47;1.11-1.95). Demyelinating events are rare in RA, but signif higher w/ TNFi https://t.co/6vUy5nsQ27
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