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Wealth and Where you Live Influences Outcomes

EurekAlert!

Patients from wealthier European countries tend to start treatment with biologics earlier but also stop or switch treatment earlier. They also experience lower disease activity at treatment start than patients in middle- and low-income countries.

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From 1975 -2025, incidence of Kawasaki dz (KD) increased 16.1-fold in Japan, KD cases 15 032 and& 14 809 in 2023 & 2024, but during COVID #s dropped to 10 333 in 2022. KD #s rebounded after the COVID-19: Infants showed minimal changes, but kids 5-9 had the greatest increase https://t.co/j0BL2ZELXn
Dr. John Cush @RheumNow (  View Tweet)
Tune in for an expert conversation on the latest data from SELECT-SWITCH, including discussion about the EULAR 2026 post hoc analysis of primary and secondary TNFi nonresponders. Sponsored by AbbVie Medical Affairs + Health Impact. https://t.co/ni7IdVFobf https://t.co/Nb2Zb6WXDs
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Simple infographic on the MOA of deucravacitinib (Sotyktu). https://t.co/fXbxMAzvAE https://t.co/6IvA0Xz3m2
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MoonLake announced positive phase 3 data from its IZAR-1 RCT using its dual A/F IL-17 inhibitor sonelokimab, showing significant responses at week 16: 66% ACR20, 42% ACR50, 41% minimal disease activity (MDA), & 61% PASI90 at week 16. a 2nd IZAR-2 PsA RCT is in progress https://t.co/eX0cxekRKG
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NP Salaries: in 7 specialties, NPs now avg >$150,000/yr, with the avg annual salary surpassing $137,000 in 2026 according toBureau of Labor Statistics. https://t.co/LlGFxkvEj5 https://t.co/h5bKsrnm4k
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Multimodal & multidisciplinary Tx (MMT) are underutilized in adults w/ chronic pain. Study of 347 Chr pain pts - 60% used non-opioid meds; 29% used opioids & only 11% MMT. Older age & high intensity pain assoc w/ Opioids. MMT had more complex pain w/ greater pain interference, https://t.co/iF0UQeut9b
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Systemic Burden of Gout https://t.co/OUgXMtH1bn https://t.co/1AtaFwZ2SR
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JAMA has updated its guidance for the acceptable use of AI in authoring a Medical Publication. Despite growing AI use, very low rates of disclosure of AI use have been reported. This is about what is permitted & not permitted & what needs to be disclosed. https://t.co/zti0OnvBV0 https://t.co/Y1C3MfJ27c
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What's New in Lyme Disease

JAMA has published an overview of new considerations on Lyme disease, focusing on Diagnostics, Vaccines, and Prevention.

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POETYK PsA-1: Deucravacitinib in Biologic-Naïve PsA

POETYK PsA-1 trial tested the disease modifying efficacy of deucravacitinib, a tyrosine kinase 2 (TYK2) inhibitor, in psoriatic arthritis (PsA) patients and was shown to be superior vs to placebo for clinical responses, patient-reported outcomes, and structural damage inhibition in PsA.

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JAMA Patient Education Page on: Therapeutic Use of Cannabis and Cannabinoids https://t.co/s6F7B9qLfr https://t.co/lpLGozJgvi
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Study of 154 anti-Ku Ab+ pts (51 IMMM, 46 SLE, 30 Sjögrens, 27 Sc) = 60 (39%) had ILD - 75% progressed; more rapidly in males. BUT Ku+ is rare <4%, not specific, without clear clinical implications. Ku is a myositis-assoc Ab (like Ro52/Ro60, U1-RNP, PM/Scl) https://t.co/MHz8mdqDqi
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UK Clinical Practice Research Database study RA pts 3134 on glucocorticoids (vs not 4142 matched controls). were identified. GC use assoc w/ signif risk of SSRI initiation risk - recent GC (adj OR 1.53) & past GC (aOR 1.40). GC effect or confounding dz activity? Think depression! https://t.co/WZLkQWlURC
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NSAIDs reduces age-related macular degeneration. TriNetX study (2015-2024) looked at non-AMD pts & showed NSAID use (n 634794) had signif less AMD at 6 mos (HR 0.31), 1 yr (0.36), 3 yrs (0.42) & 5 yrs (0.48); w/ signif protective effect (HR 0.58), Same for ASA (0.72) & https://t.co/Cgxrz92Omt
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Air Pollution Increases RA Activity and Flares Koreans with rheumatoid arthritis (RA) showed increased disease activity and higher flare rates when exposed to relatively high levels of small atmospheric particulate matter, researchers reported. https://t.co/9dZkTzivRz https://t.co/Reic3P5U6r
Dr. John Cush @RheumNow (  View Tweet)
Rethinking Treatment of EGPA Like MPA & GPA, the goals of EGPA are controlling initial organ damage and preventing relapse. But EGPA has the added challenge of chronic upper and lower respiratory tract involvement, allergic type 2 inflammations and risk of glucocorticoid https://t.co/KIVpyhsghg
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Korean study of 1070 #RA pts. assessed for Dz activity & monthly pollution exposure (SO2, NO2, ozone, CO, PM10, PM2.5). Among 6 pollutants, PM2.5 signif incr risk of flare (adj OR 1.11) & DAS28-CRP, CDAI, TJC, SJC; more so w/ in women & nonsmokers & w/ prolonged PM2.5 exposure https://t.co/HgtWMz9LMs
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“We may have all come on different ships; but we’re in the same boat now.” -Martin Luther King, Jr.

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