Is Acetaminophen Potentially Hazardous in Pregnancy?
Sep 27, 2021
Recent News
Read ArticleA consensus report from a multinational group of 91 scientists, clinicians and public health professionals alarmed the medical world last week as they suggest the use of acetaminophen (paracetamol) during pregnancy may have hazardous developmental effects on the fetus.
Post-Arthroscopic Increase in Septic Arthritis
Sep 27, 2021
A longitudinal study from Iceland shows an increasing number of native joint infections (NJI), with iatrogenic, postarthroscopic infections being of particular concern.
Read Article
10 Signs You'd Make a Great Pathologist
#PathTwitter #MedTwitter
1. You've been told that you "ask too many questions" at some point in your life.
Becca Brass, MD @BeccaBrass ( View Tweet)
Sep 27, 2021
108 pts with autoimmune cytopenias (TTP, ITP, AIHA, etc) were given COVID vaccination showing low rate of post-vax flares. Signif HEME decreases in 7.4% of AIHA & ITP; mild decrease in 10% AIHA and 20% ITP, w/ no Rx change https://t.co/OaHILar57z
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 27, 2021
Variance in Uric acid? 85 pts without gout & serial SUA measured. 72/85 had nl SUA, but 21% later had high SUA x1. If SUA < 6, much less like to have future hyperuricemia (7% vs 39%, p = 0.0037). 13 w/ high SUA, half later had nl SUA. https://t.co/w05ll3OMbJ
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 27, 2021
Global SECURE-IBD trial on IBD drugs and COVID shows that severe COVID-19 outcomes were not associated with the use of biologics and mesalamine/sulfasalazine, AZA, 6MP, MTX combo Rx or biologics (TNFi, IL-12/23, IL-23, integrin inhib) https://t.co/MO4i5ngKkr
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 27, 2021
Prospective study of 77 RA patients in remission --> vax w/ BNT162b2 (BioNTech-Pfizer) (w/ temp D/C of DMARDs per ACR) found a vaccine-related flare rate of 7/8% (6 pts) w/ 5/6 flares after 2nd dose (2.6 days), resolved w/in 2 wks https://t.co/YOL3YVArvG #RheumNow https://t.co/dxRWhu8CJX
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 27, 2021
Can I get the INFLUENZA and COVID Vaccines together? The CDC says: "YES...both vaccines can be given at the same visit, people should follow the recommended schedule for either vaccine.... ideally get a flu vaccine by the end of October." https://t.co/T49zm6Cxyc
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 27, 2021
Patients with rheumatoid arthritis (RA) who had a history of cancer did NOT have an increased risk of new or recurrent cancers if treated with biologic therapies, a meta-analysis found. #RheumNow
https://t.co/jM9oiRzXUk https://t.co/XYnaalEfe2
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 27, 2021
NEJM Image Challenge: A patient presented with painful and erythematous plaques on his hands and elbows. Lab examinations showed leukocytosis and thrombocytopenia. What is the diagnosis? https://t.co/kQrNuVmVXg https://t.co/4JGeExCcP7
Links:
NEJM @NEJM ( View Tweet)
Sep 26, 2021
Aortitis: Let’s review the differential for #aortitis including Non-Infectious and Infectious Causes!
@febrilepodcast x @RheumOnePagers | created by @MithuRheum @swinndong
#IDTwitter #RheumTwitter #FOAMed https://t.co/pR0iTls4PK
Rheum OnePagers @RheumOnePagers ( View Tweet)
Sep 26, 2021
New study on #COVID19Vaccine in autoimmune cytopenias
🩸7.4% had clinically significant ⬇️ in counts
🩸 All successfully managed w/steroids & transfusion
🩸 Mild ⬇️ in 10% AIHA and 20% ITP
⭐️Vaccination safe with close monitoring⭐️
https://t.co/qGZe6LiPKz
AmericanJournalofHematology @AjHematology ( View Tweet)
Sep 26, 2021
No Recurrent Cancer Risk With Biologic Treatment of RA
MedPage Today
Sep 24, 2021
Patients with rheumatoid arthritis (RA) who had a history of cancer did not have an increased risk of new or recurrent cancers if treated with biologic therapies, a meta-analysis found.
Read Article
Pooled analysis of the DISCOVER-1 and DISCOVER-2 trials have shown that guselkumab, an IL-23 inhibitor, was effective and safe in psoriatic arthritis (PsA) patients with axial involvement and imaging-confirmed sacroiliitis. #RheumNow
https://t.co/yLCxyC1oLr https://t.co/Uloqx2phlh
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 24, 2021
The #1 question I get from new consults: “How did I get arthritis?” Here is my list of 11 drugs (or drug classes) known to cause arthritis or rheumatic disorders (as an unintended consequence). #RheumNow https://t.co/GsV0Qj9ENr https://t.co/IrTkY5yFdY
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 24, 2021
Study of 435 #SLE pts seen during the pandemic. Comparing those seen F2F vs telemedicine, there was no significant difference in SLE disease activity (by SLEDAI-2K) or SLE flare rates or steroid prescribing between visit types https://t.co/kscU9CbqVM
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 24, 2021
Prescribe antimalarial dosages at 5 mg/kg/d or less.... A baseline retinal exam w/ optical coherence tomography should be performed w/in 6 mos...to rule out confounding Dz. Pts at low risk for retinopathy do not require annual screening until 5 years.. https://t.co/l3sCxOJLNJ
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 24, 2021
Encouraging DBRPCT of Rituximab in #PMR: 116 screened, 49 enrolled, 47 completed: 23 on RTX vs 24 on PBO. Steroid-free remission at 21 wks seen with 11/23 (48%) RTX pts vs 5/24 (21%) on PBO (p=0·049). Infusion Rxns: 10 RTX vs 3 PBO); 1 SAE (PE) on RTX https://t.co/U2ZGNrpi0i
Links:
Dr. John Cush @RheumNow ( View Tweet)
Sep 24, 2021
RheumNow Podcast – I Wanna New Drug.V2 (9.24.2021)
Sep 23, 2021
Almost three years ago to the day, I did a podcast entitled, "I wanna new drug." As I go over this week's podcast, I want to say it again. I want a new drug safe enough to use during pregnancy, for PMR, for GVHD, and more. I'm going to cover these, and other topics including lupus, COVID breakthrough infections, and statin use and the risk of RA, as I review the news and journal articles from the past week on RheumNow.
Read Article
Guselkumab Treats Axial Disease in Psoriatic Arthritis
Sep 23, 2021
Pooled analysis of the DISCOVER-1 and DISCOVER-2 trials have shown that guselkumab, an IL-23 inhibitor, was effective and safe in psoriatic arthritis (PsA) patients with axial involvement and imaging-confirmed sacroiliitis.
Read Article
11 Drugs That Cause Arthritis
Sep 23, 2021
This is the #1 question I get from new consults: “How did I get arthritis?” But as aching patients ask this question, they are really thinking these joint complaints must be due to something.
Read Article
From the blog
As many of you are aware, I have written and spoken on COVID-19 extensively over these past 20 months, and just last month wrote about the dangers of the delta variant. In July, things took an unexpected turn when I developed a breakthrough infection with the delta variant.
Recent Podcasts
- RheumNow Podcast – I Wanna New Drug.V2 (9.24.2021)Sep 24, 2021
- RheumNow Podcast – Do More DMARDs Mean More Switching? (9.17.2021)Sep 17, 2021
- RheumNow Podcast – Do More DMARDs Mean More Switching? (9.17.2021)Sep 17, 2021
- RheumNow Podcast – High Science and Future Treatments (9.10.2021)Sep 10, 2021
- Rheumatologist Views on new FDA JAK inhibitor Boxed WarningsSep 03, 2021
Therapeutic Update
A Patient-Focused Approach to the Treatment of Rheumatoid Arthritis
Sponsored by AbbVie Medical Affairs
Sep 01, 2021
Do your patients with RA report persistent symptoms despite improved inflammatory markers? Listen to Dr. Wright discuss the importance of patient-focused measures and read about SELECT-COMPARE’s patient-driven data.
Read Post
