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Recommendations – Good & Bad (5.27.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news, regulatory updates and journal reports from the past week on RheumNow.com. This week gout worries, mortality risks, measuring anti-drug antibodies and a better way in lupus?

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Can SGLT2 Inhibitors Be Protective in Lupus and Vasculitis?

Jack Cush, MD

SGLT2 inhibitors are all the buzz in the renal world with reports of a renal protective and mortality lowering effects. Maybe these agents should be considered and studied in lupus nephritis and ANCA- associated vasculitis.

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Relevance of Raynaud’s in Systemic Sclerosis

Jack Cush, MD

Raynaud’s phenomenon (RP) is integral to the diagnosis and management of systemic sclerosis (SSc) patients; a recent analysis suggests that RP should be characterized based on color change and the presence of other symptoms to know whether RP portends more serious manifestations.

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Malar,rash,SLE, Lupus

Rising Incidence of Systemic Lupus Erythematosus

Jack Cush, MD

Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing.



SLE was diagnosed using the EULAR/ACR criteria and looked at patients seen between 1976–2018.

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Methotrexate Monitoring (5.13.2022)

Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.

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Making You the Expert of You! (Smart Rules for Patients)

Jack Cush, MD

You’ve scheduled an appointment with your medical provider - how do you make the most of it? We've gathered these tips and suggestions to share with patients.

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To TDM or Not in Rheumatology? Therapeutic Drug Monitoring (TDM), especially for biologic therapies, has become a standard in gastroenterology, but shunned by most rheumatologists. But now, EULAR has a recommendation... https://t.co/u86Vd8bFGr #MedEdTwitter https://t.co/IpKqPoWM9R

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Can SGLT2 Inhibitors Be Protective in Lupus and Vasculitis? SGLT2 inhibitors are all the buzz in the renal world with reports of a renal protective and mortality lowering effects https://t.co/9mzE06K9uO #MedEd https://t.co/dVgOtCSHFU

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Dr. John Cush RheumNow ( View Tweet)
86 #SLE pts w/ pulmonary embolism (age 38 yrs; avg lupus duration 46.5 mos) found 20% died; 1 yr (83.4%) & 3-year survival (79.4%). Mortality Predictors = Thrombocytopenia & lymphocytopenia. HCQ & anticoagulation were protective https://t.co/ot7H6LeLmu https://t.co/WdPgvOF8jJ

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It's our 8th year covering this important meeting! Join us June 1 - 4 for key opinion leader perspectives, clinical trial highlights and more, as we cover #EULAR2022. https://t.co/eHziBN3TWk
Dr. John Cush RheumNow ( View Tweet)
Watch: Lupus Nephritis: The Blind Men and the Kidney with Dr. Joan Merrill Joan Merrill discusses treatment of lupus nephritis. This was previously recorded at RheumNow Live 2022. https://t.co/IDjOT3Acs0 https://t.co/HkYcoRx5P4

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Dr. John Cush RheumNow ( View Tweet)
Rising Incidence of Systemic Lupus Erythematosus Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing. https://t.co/GUakRwwWQw https://t.co/LPnVMTT8Ro

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Dr. John Cush RheumNow ( View Tweet)
Ontario population study shows that musculoskeletal disorders account for 12.3% of all adult emergency dept. visits and 28.5% outpatient physician visits https://t.co/Sq9n7RkIYK https://t.co/lKtQqR5Ja3

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Dr. John Cush RheumNow ( View Tweet)
Watch: The Almighty ANA Dr. Lipsky discussed how our thinking and use of ANA and serologic testing has evolved and is crucial to outcomes and trials in his lecture, The Almighty ANA, presented during the at #RNL2022 in March. #lupus https://t.co/Xxxj18badY https://t.co/5pwV4xSGDx

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Watch: Pregnancy Paradox: How Stopping Drugs Leads to Greater Harm Uma Mahadevan, MD talks about the pregnancy paradox and how stopping medications in pregnancy to protect the fetus can actually lead to greater harm. https://t.co/HYO5BdjwzZ https://t.co/IGeZ3O8Dno

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Dr. John Cush RheumNow ( View Tweet)
Rising Incidence of Systemic Lupus Erythematosus Data from Olmstead county, MN over the past four decades shows that the incidence and prevalence of systemic lupus erythematosus (SLE) is increasing. https://t.co/LCDmVS5UVb https://t.co/f3z6BlURkj

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Dr. John Cush RheumNow ( View Tweet)
24 week, Phase II RCT of baricitinib in 314 active #SLE patients showed significant reductions in levels of dsDNA, IgG, Sm & ACL Abs; but had no effect on C3/C4, RNP, SSA, SSB. Changes in dsDNA did not correlate with SRI-4 responses though.https://t.co/cF6rHbtvf9 https://t.co/zXnUImaLHF

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Dr. John Cush RheumNow ( View Tweet)
Risk factors for readmission among 132,400 #SLE hospitalizatiions included young SLE, AIHA (OR 1.86) GN (OR 1.41) pericarditis (OR 1.4), CHF(OR 1.38), Medicare (OR 1.2), Medicaid (OR 1.26). Most Readm Dxs were Sepsis, CHF, pneumonia https://t.co/Nr9bCGDaw0 https://t.co/THO6KT6dWV

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Making You the Expert of You! (Smart Rules for Patients) You’ve scheduled an appointment with your medical provider - how do you make the most of it? https://t.co/62mTqk4ksL https://t.co/gr7Hvt7EI3

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Dr. John Cush RheumNow ( View Tweet)
Evobrutinib, selective oral BTK inhibitor, has been studied in >1083 pts in phase 3 RCTs of RA, SLE, MS; shows well tolerated, most common AE ≥5% UTI (9.5%), nasopharyngitis (7.3%), diarrhea (6.2%), transient ^LFTs, SIE rate 2.72/100 PYs https://t.co/NTKYOAHhln https://t.co/oUKCDicjyA

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Dr. John Cush RheumNow ( View Tweet)
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