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Congenital Heart Block: Dangers Ahead

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d RheumNow

Mar 07, 2019

Children of autoantibody-positive mothers who were born with congenital heart block were at high risk for developing later cardiovascular and autoimmune disorders, as were their siblings, Swedish researchers reported.

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Biologic Agents have Equal Efficacy in Enthesitis and Dactylitis

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d Jack Cush, MD

Mar 06, 2019

A systematic review has shown that TNF inhibitors (TNFi) are equaled in efficacy by other biologic agents (ustekinumab, secukinumab, and ixekizumab) in psoriatic arthritis (PsA) patients with in dactylitis and enthesitis.

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Lower Mortality Results from Lower Activity in Lupus

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d Jack Cush, MD

Mar 06, 2019

Data from the longitudinal Tromsø Lupus Cohort study has shown that lupus patients who achieve a Lupus Low Disease Activity State (LLDAS‐50) were shown to have significantly less severe damage, and a reduction in mortality.

This was a population‐based study of SLE patients in the northern‐most counties of Norway.

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Dual IL-17 Inhibitor in Psoriasis Succeeds

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d RheumNow

Mar 05, 2019

Patients with moderate-to-severe plaque psoriasis attained durable complete and near-complete responses for more than a year with a dual inhibitor of interleukin (IL)-17, data from a randomized trial showed.

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Medical Meetings: Should I Stay or Should I Go?

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d RheumNow

Mar 05, 2019

Say a conference in your field was just announced. You think you "should" go, and you know you'll be choosing from many presentation opportunities that feature the latest research — which you want to know about. And you'll get to hang with like minds and talk about things that matter.

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Claims analysis from Natl Taiwan Health Database, compared 262 JIA pts w/ controls & showed JIA pts have 30 fold higher risk of an adult autoimmune dz- Hazard Ratio=129.5 for RA; aHR-10.1 SLE, 49.62 AS & 8.2 PsA. Highest risk (46x) for JIA onset 11-15 yrs https://t.co/oL3stNLYvc

Links:

https://buff.ly/2SKBgvd

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2019

Risk of pancreatitis with azathioprine in adults estimated to be 3-7%, but unknown in kids. 3374 pairs of pediatric IBD pts compared pts on AZA vs not. AZA use was associated with a 5.82 events/100PY risk of pancreatitis (AZA 49·1 vs NOT 8·4 events/100PY) https://t.co/arap2ShTPN

Links:

https://buff.ly/2HkIlAm

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2019

Rule of thumb on VTE risks: Normal population 0-.4/100PYs; RA patients are increased at 0.3-0.7/100 PY. If a new RA drug were to cause VTE (venous thromboembolic events; DVT/PE) it would have to have a rate consistently higher than 0.5 and probably higher than 0.7/100PY

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2019

The PARA study shows among 249 pregnancies (2002-2008), breastfeading was less in RA - at 4-6, 12 & 26 wks postpartum 43%, 26% and 9% of the RA breastfed (vs 63%, 46% & 41% in controls). Many patients D/C breastfeeding so they could start medication. https://t.co/ONf1jgFJYL

Links:

https://buff.ly/2IUIFYW

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2019

A study of 2,369 patients with fibromyalgia showed the mean time from initial complaint to diagnosis was 6.42 years. Comorbidity, younger patient, and older physician age were associated with longer time to diagnosis. https://t.co/mHGIR7C4PW

Links:

https://buff.ly/2SNnurL

Dr. John Cush RheumNow ( View Tweet)

Mar 07, 2019

QD Clinic - Five Leflunomide Pearls | from RheumNow https://t.co/A4dwd0eTQ9

Links:

https://buff.ly/2tUI0ww

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2019

Very 1st case I heard on Rheum Rounds 1984 was on Moya-Moya. A review of Delay & mis-Dx in 38% of 192 pts - time to Dx=mean 5.28 yrs; usually misDx as cerebral vasculitis (31%), stroke(30%) & MS(3.6%). Moyamoya is progressive, occlusive cerebrovascular Dz https://t.co/cxu7s3snEJ

Links:

https://buff.ly/2IStjnZ

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2019

Pt with a history of gout. Acute onset of pain at 1st MTP joint. Ultrasound shows 1st MTP Synovitis. Synovial thickening with hypervascularity is noted on the dorsal aspect of 1st metatarsophalangeal joint. https://t.co/BH4C56Yerq

Links:

https://buff.ly/2HmVCsr

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2019

From CreakyJoints- 20 Things pts wish their Rheums Knew: 1 Fix the Vocab, 2 Dont rush me, 3 Dont sugarcoat, 4 Realistic diet, 5 Listen to me, 6 Dont judge me, 7 Flares last longer than you think, 8 Do a mental check up; AND MORE https://t.co/TuKIn86RNv

Links:

https://buff.ly/2Hhqhaw

Dr. John Cush RheumNow ( View Tweet)

Mar 06, 2019

Surprising Resignation by FDA Commissioner Scott Gottlieb - cites need for more family. Does so after bring vaping, costs and opioids into the spotlight. Could Rheumatologist Janet Woodcock be the next candidate? https://t.co/FnL7Wn0jnT

Links:

https://buff.ly/2NIUQXx

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2019

From PRECISION study (high risk CV pts), Solomon et al shows a toxicity score (age, sex,CV hx,HTN, DM, tobacco, statins, creatinine, HCt, RA v OA) can predict risk of CV events: ~5% at low risk (<1%), 69% at intermediate risk (1- 4%), 27% high risk (>4%). https://t.co/nMXBMdaxvE

Links:

https://buff.ly/2SI3QNM

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2019

Could Metformin be adjunctive in gout? MSU crystals induce mTOR signalling in monocytes; sam pathway strongly implicated in CV & metabolic disease. Ex vivo studies show high higher mTOR expression gout - downreg by metformin or rapamycin https://t.co/qA3a9WCUq8

Links:

https://buff.ly/2tPToJO

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2019

An Internet survey of 320 physician-diagnosed #gout pts finds that 23% diagnosed as having a sleep disorder (sleep apnea, 17%). Their mean sleep time was 6.7 h per night; 86% reported snoring during sleep and 2/3 reported feeling sleepy during the day https://t.co/7DiuZOM1aw

Links:

https://buff.ly/2tPvRZG

Dr. John Cush RheumNow ( View Tweet)

Mar 05, 2019

QD Clinic from RheumNow - what to think and expect with Pregnancy and Dermatomyositis https://t.co/Fq6at8bP1i

Links:

https://buff.ly/2Xzd4PU

Dr. John Cush RheumNow ( View Tweet)

Mar 04, 2019

You can view RheumNow Live (Mar 22-24) for free, ONLINE. A Great with the Best Faculty. Register here https://t.co/m22mZf6JFG

Links:

https://buff.ly/2qX0Mlplecture

Dr. John Cush RheumNow ( View Tweet)

Mar 04, 2019

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