FDA Panel Advises Stronger Warnings on Fluoroquinolones

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An FDA Advisory Panel reviewed the safety of fluoroquinolones and their use to treat sinus infections, urinary-tract infections and bronchitis.

Hip Fracture Risk Factors in the Elderly

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As risk of hip fracture increases with advanced age, our knowledge of risk factors for hip fracture among very old people remains limited.

Knee OA (not Hand) is Associated with Higher Mortality in Women

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"Doc....the pain is killing me."

This oft heard patient complaint may be truer than you think.

Features Predict Chronicity in Myositis

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Certain serologic and clinical features can help predict a chronic disease course among children with juvenile idiopathic inflammatory myopathies (JIIM), a large registry study showed.

Biosimilars and the FDA

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Biosimilars are in the news and will be prominently on parade at next week's ACR meeting in San Francisco. Biosimilars are similar to, but not the same as, innovator biologics.

Increasing Trends for Prescription Drugs, But Not for Arthritis Drugs

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JAMA reports the results of trends in drug use in the USA over a 13 year period using data derived 37959 adults survey in the National Health and Nutrition Examination Survey (NHANES).

Increasing Risk of Septic Arthritis with Age

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A retrospective population-based study from New Zealand examined the epidemiology, clinical features, and microbiology of adult native joint septic arthritis.

Economic Burden of ANCA-Associated Vasculitis in the USA

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To assess the prevalence and magnitude of healthcare costs associated with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) in the USA, researchers analyzed adminstrative data from Truven Health MarketScan Commercial and Medicare Supplemental databases.

Wine, Lupus, Pregnancy and Biosimilars: October 2015 -Top Social Media News

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In October 2015, RheumNow published 76 tweets about impactful news, research and teaching points that impact the rheumatology community. In October, RN had a reach (impressions) of 49,500, 79 mentions, and over 2000 visits to RheumNow.com to check out what we publish.

More Adverse Events with Off-Label Drug Use

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Off-label use of prescription drugs was associated with adverse drug events in a study of patients in Canada,  according to an article published online by JAMA Internal Medicine.

Repeat Skin Cancer Risk with Methotrexate and Biologics

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Using Medicare claims data, a retrospective cohort study analyzed the risk of a second non-melanomatous skin cancer (NMSC) in 9460 individuals (6841 with RA and 2788 with IBD).

DSB: Drug Shortages - October 2015

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Each month, RheumNow reviews compiled listings of drug shortages germane to the practive of rheumatology using several sources. If you have suggestions or information about specific drug shortages or drug safety issues please email us at info@rheumnow.

No Correlation Between Urate Crystal Identification and Cardiovascular Risk

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A Danish cohort study examined patients with hyperuricemia  and compared outcomes in those proven to have urate crystal deposition (317 patients) and matched 1:1 to patients without urate crystals.

Study Backs CellCept for ILD in Scleroderma

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MONTREAL -- An immunosuppressive drug was as effective as a standard agent for interstitial lung disease (ILD) associated with scleroderma, a researcher said.

ANCA Levels Predict Relapse in ANCA-Associated Vasculitis

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A team of Japanese investigators examine 126 patients with ANCA-associated renal vasculitis to see if ANCA levels would predict disease relapse.

Downward Trends in US Mortality Statistics

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Using death certificate data from US National Vital Statistics System of the National Center for Health Statistics (NCHS) and the Centers for Disease Control and Prevention, JAMA reports a downward trend in death rates in the USA from 1969 - 2013).

Obamacare Deficient in Rheumatologists, Other Specialists

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The October 27 issue of JAMA reports a study of federal marketplace insurance plans shows roughly 15 percent completely lacked in-network physicians for at least one specialty, a practice found among multiple states and issuers.

High Level Skin Responses Seen with Inhibitor of IL-23p19 in Psoriasis

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Rheumatology News reports the results of a novel trial presented at the European Academy of Dermatology and Venereology meeting in Copenhagen.

FDA Panel Votes 10-4 to Approve Lesinurad for the Treatment of Hyperuricemia/Gout

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Despite concerns over safety, the FDA Arthritis Advisory Committee voted favorably to approve lesinurad (LES) at a meeting held Friday, October 23, 2015. Overall, panel members felt the potential benefits of LES outweighed the safety concerns reviewed by the FDA presenters.

Vertebral Fractures in 10% of Spondyloarthritis Patients

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Vertebral fractures are not uncommon in patients with ankylosing spondylitis and spondyloarthritis.