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Patients diagnosed with interstitial pneumonia with autoimmune features (IPAF) are at an increased risk of developing a systemic autoimmune rheumatic disease (ARD).
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Dr. Jack Cush reviews the News and Journal Reports from this week on RheumNow.com.
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The American Society for Bone and Mineral Research has developed multistakeholder consensus clinical recommendations for the prevention of secondary fractures for those aged 65 years and older after an initial hip or vertebral fracture.
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JAMA Internal Medicine has an analysis of the growing trend of more women enrolling in medical schools in the last few decades, such that more than half of US Med school matriculants in 2017 were women. Also in 2017, 42% of residents in internal medicine were women. The reported analy
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The Annals of Rheumatic Disease reports a psoriatic arthritis study where in ixekizumab was non-inferior to adalimumab for achievement of ACR50 responses but was superior to adalimumab for achievement of PASI100 by week 24.
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While the efficacy and safety of interleukin 1 (IL-1) inhibitors (e.g., anakinra) in the acute management of gout and pseudogout has been repeatedly shown, the cost efficacy of such biologic therapy has rendered it impractical for most. A new retrospective study has shown that IL-1 inhibitors may be effective and appropriate for some medically complex, hospitalized patients with acute gout or calcium pyrophosphate crystal arthritis.
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The NEJM reports on a randomized comparison of hemiarthroplasty and total hip arthroplasty in displaced femoral neck fractures and shows no difference in function and quality of life over 24 months.
Dr. John Cush
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N. Zealand study shows their cost of knee OA was $200 million in 2013; and without any changes in the standards of care, this isprojected to increase to $370 million by 2038. (includes an additional 4,000 TKRs per year by 2038). https://t.co/B1awh1ky1B
Dr. John Cush
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Claims study of RA, PsA, AS/SpA patients on TNF inhibitors shows a comparison of 31,527 MTX vs 34,651 TNFi initiators. MTX was D/C sooner in PsA & AS [aHR 1.10, 1.23) vs RA pts. Concomitant MTX reduced risk of TNFi D/C in all [aHR 0.85, 0.81, 0.79] https://t.co/0l2J2FDsUm
Dr. John Cush
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Might Vioxx make a backdoor comeback? 2017 Vioxx went off patent, now a small pharma has applied to the FDA for orphan drug approval of rofecoxib (& etoricoxib) to treat hemophiliac arthropathy (large unmet need). Say it aint so! https://t.co/kENHHhcyIT https://t.co/QpDNiaCZyz
Dr. John Cush
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Choi and colleagues have shown that allopurinol-associated severe cutaneous adverse reactions are higher with Heart (RR 1.44) and Renal (11 fold) disease. Initating low-dosage allopurinol may substantially mitigate this risk. https://t.co/gyj7Xn3uhx
Dr. John Cush
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MotherToBaby Pregnancy Study in 528 RA pts has shown oral steroid use yields a dose dependent risk of pre-term birth. PTB was increased high dose (RR: 4.77) and medium dose (aRR: 1.81) OCS in the 1st 139 gestational days; DMARDs/biologics were not https://t.co/cuggovK8eL
Dr. John Cush
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Analysis of retail pharmacies and drug costs show that, compared to large chain pharmacies, big box was 48% cheaper, followed by grocery-based (18% cheaper), next small chain (51% higher), and independent pharmacies (61% higher) https://t.co/jlQnNboiAR
Dr. John Cush
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Approximately 20–30% of IBD patients will develop spondyloarthritis. Using a survey tool on 244 IBD pts they found 21% with sufficient criteria to suspect SpA - Other risk factors included being female, Crohn's, prior DMARD or biologic drug use. https://t.co/9Ail7syLmB
Adam Cifu
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One of my favorite things about writing "health humanities" pieces for journals are the gracious, thoughtful, insightful notes I get from fellow docs. This one arrived in my inbox this AM. Humbling in its perfection.
In response to this article: https://t.co/9uPvPDOPAI https://t.co/85usMOPqlb
Adam Cifu
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Felt the need to update my 10 commandments. Fortunately, on twitter, commandments are not written in stone. https://t.co/Rt9YDW8lFh
Gabe Charbonneau, MD
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"Physicians don’t hate technology – they have smartphones, fitness trackers and tablets just like everyone else – what they hate is bad technology."
Truth. #fightburnout
https://t.co/qTG0jZFtDL
Dr. John Cush
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Survey for Rheumatologists - You would use an MRI in an RA to assess what?
Dr. John Cush
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Kaiser study of 1956 SLE patients shows only 58% of were adherent (≥ 80%) to hydroxychloroquine; not predicted by the Rheum, hospital or socioeconomics. Risk factors for nonadherence included age, being white, # of Rheum visits/yr. https://t.co/qRdJRGvRAr
Dr. John Cush
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Retrospective claims study shows that higher ACPA and RF titers were independently associated with 60-78% increased mortality in established RA; the association persisted in when Rx with DMARDs, but not with biologics. https://t.co/hHJx4alNIQ
