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The Annual Review of Best ACR 2020 abstracts featuring Drs. Cush and Kavanaugh filmed on the last day of Virtual ACR 2020 Nov. 9, 2020. Watch now!
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Pregnancy in SLE is a high risk situation and active disease can lead to fetal loss, pre-term birth, IUGR and neonatal lupus syndromes. In a study by Dr. Michelle Petri and colleagues, they evaluated whether the LLDAS at the start of pregnancy was predictive of pregnancy outcome.
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Here are my highlights from day three, Sunday, of the ACR 2020 Convergence.
Meral K. El Ramahi, MD
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Summary of #ACR20 part B:
- The future is bright with many trainees producing great research per Dr. Diane Karen
- Belimumab (phase III) reduced proteinuria, improved renal for, and helped w/ tapering of GC in pts w/ lupus nephritis but more infect in GC group @RheumNow
Eric Dein
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#ACR20 imaging competition: 27 yo F with h/o SLE nephritis s/p kidney transplant p/w abdominal pain due to abdominal wall tophus @RheumNow. https://t.co/iDlF3neIYM
Dr. John Cush
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Rheum Now shares Day 3 highlights from #ACR20.
https://t.co/xNv1fG97ib https://t.co/Psa8bRqlVh
American College of Rheumatology
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With Phase 2 of the Accelerating Medicines Partnership study of SLE underway, an #ACR20 session featured a panel that reviewed the methods being used to generate data & discussed some of the findings. Read the recap → https://t.co/hTnCdfBn10
Janet Pope
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@uptoTate @RheumNow Agree. MD global is Often SJC taking into consideration activity severity and location of joints. Ex SJC of two ankles or knees is higher MD global than 2 MCPs. All N of SJC are not =. @RheumNow
Mrinalini Dey
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Very low #vitaminD levels <20ng/mL are associated with renal insufficiency in patients with #SLE.
Abs#1789 #ACR20 @RheumNow
https://t.co/dBm3ZlQOso
Dr. John Cush
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Smartphone T2T management of RA & SLE is possible. With over 127,316 DAS28 & 42,593 SLEDAI assessments over 2 yrs. T2T was lowest in spring for both, correlating w/ holidays in China. #ACR20 Abstr#1018 https://t.co/bGJtSTDqzo https://t.co/34za6kokOp
sheila
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Dr. Petri et al: Very ⬇ 25(OH)Vit D levels (<20ng/mL) is associated w/ renal insufficiency in SLE
🚨Levels >60ng/mL can ⬆renal insufficiency
This reinforces benefits of Vit.D supplementation (⬇ protnuria; immunomodulation)
@RheumNow #ACR20 abs1789 https://t.co/BJciK77fcp
Mrinalini Dey
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#AerobicExercise improves #Fatigue & #QualityofLife in women w/ #SLE
- ↓Fatigue & ↑overall health after exercise program
- No increase in #lupus activity
- Data may inform understanding of fatigue & exercise interventions in SLE
Abs#1838 #ACR20 @RheumNow
https://t.co/0YtYHrWp6t
sheila
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Data from Prof. Michelle Petri's study showed double+ or triple+ aPLs were not superior to single LAC+ for risk of thrombosis in #SLE patients. @RheumNow #ACR20 https://t.co/uDHsbd1Y1k
Janet Pope
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After #COVID19 there may be more #LUPUS due to...@RheumNow @CRASCRRheum #ACR20
Peter Nash
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Herpes Zoster Events with Anifrolumab in Patients with Active SLE: An Integrated Analysis of Phase 2 and Phase 3 Trials https://t.co/70oOHXihFb #SLE #zoster x 4-5 times increase in zoster
Eric Dein
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@jhrheumatology Michelle Petri MD MPH: thrombosis risk composite score = Low C3 + dRVVT + Platelet C4d. Abst#1513. PltC4d associated with proteinuria, venous/arterial thrombosis. #ACR20 @RheumNow https://t.co/OdAjul5Usg
Eric Dein
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@andreafava @jhrheumatology shows class switch is common in lupus nephritis biopsy, chronicity scores are critical. Shows value of need for liquid biopsy @rheumnow #ACR20 Abst#1512 https://t.co/M0DWmTLP29
Dr. Rachel Tate
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Dr. Crow's #StateoftheArt lecture revealed that BEL may be best used in pts with < 2 years and SLEDAI >10 based on the study from Gatto, M et al from 2020. Does this change how you will use BEL in your practice? #ACR20 @RheumNow
David Liew
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We were always taught that rheumatic disease ILD is v bad in pregnancy.
Fetal outcomes are def bad in severe ILD, but no maternal deaths/few Cx.
May not need to avoid pregnancy/electively terminate!
Largest-to-date cohort @dukemedicine n=94
@drbags71 #ACR20 ABST1446 @RheumNow https://t.co/E7BDHn8KJb
sheila
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This study identified novel RFs for RA-ILD:
Obesity
⬆CRP(≥10mg/L)
Poor function(MDHAQ ≥1)
High education
30py smoking hx assoc'd w/⬆ RA-ILD risk
Do u counsel RA pts on smoking cessation & lifestyle change? @Rheumnow #ACR20 abs1198 #ACRbest @jeffsparks https://t.co/jvZ26n8k5p
