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RheumNow Podcast – Boiling Hot MAS (7.12.19)

Jul 11, 2019 8:46 pm

Dr. Jack Cush reviews this week's news and journal reports featured on RheumNow.com.

  1. Swedish registry comparison of 541 PsA 40944 non-PsA pregnancies between 1997-2014, shows PsA pregnancies had increased risks for preterm birth (adj OR 1.63) and caesarean deliveries (OR 1.47), but no increased risks for pre-eclampsia, stillbirth https://buff.ly/2G7IS7j 
  2. Analysis of 14 studies & 3291 Psoriatic arthritis patients shows the overall frequency of anti-CCP antibodies=9.8%. In PsA, CCP+ was associated with increased risks of polyarthritis (OR 4.4), bone erosion (2.8), and dactylitis (1.98), but not of enthesitis. https://t.co/hM11ZaskfV   
  3. Study of 182 hospitalized adult-onset Still's disease patients shows predictive factors for developing macrophage activation syndrome to include: 1. Splenomegaly (OR 5.745), 2. pericarditis (OR 6.5), and 3. ferritin >2000 (OR 4.7). https://t.co/oNsaCL6O92   
  4. Increased time spent in lupus low dz activity state (LLDAS) reduces healthcare costs. Among 212 SLE pts analyzed; increased cost assoc w/ damage & steroid use, but spending ≥50% of time in LLDAS resulted in a 26% reduction in direct medical cost https://t.co/Kfd064kZFX 
  5. Study of 28 states and 10,268 lupus Medicaid patients showed that only 15% were adherent to HCQ  treatment. Adherence was lower in blacks living in certain zip codes but not in zip codes prevalents for Hispanic, white, education, poverty level. https://t.co/ytFXaOGKB2   
  6. Metanalysis of 277 RCTs &1 million evaluated 16 nutritional supplements & 8 dietary interventions showed largely no effect on mortality and CV outcomes in adults. There was evidence favoring reduced salt & omega-3, long-chain fatty acids. https://t.co/sojx842jLt   
  7. A nested case-control study of 120 SLE pts matched against 240 controls and showed the risk of serious infections was associated with serositis (OR 2.76), hematologic involvement (OR 2.53) and daily steroid (>7.5mg/d) use (OR, 2.53). https://t.co/5zqV9jsNq1 
  8. Survey of 1000 customers of two adult-use cannabis retail stores in Colorado shows that 65% of adults use cannabis to relieve pain & 74% use it to promote sleep. Over 80% said that cannabis was very or extremely helpful for pain or sleep. https://t.co/euDm7yq7Rc   
  9. CBD isn't entirely safe. Forbes reviews evidence of hepatotoxicity, esp with the CBD-based epilepsy drug Epidiolex; in studies 5-20% had liver issues. FDA has also warned of suicidal ideation, agitation, suicide, depression, aggression & panic attacks https://t.co/I83QVXwsl6
  10. Modest Improvements of Tanezumab in Osteoarthritis Offset by Safety Data  
  11. Pregnancy Outcomes Improve in Lupus    

 

Disclosures
The author has received compensation as an advisor or consultant on this subject

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