The question as to how autoimmune rheumatic disease patients fare with the COVID vaccine is one being asked in rheumatologists’ offices everywhere this year, and at the EULAR 2021 Virtual Congress, data presented from Israel, one of the first countries to vaccinate on a br
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Check out this compilation of our EULAR 2021 Day 2 broadcasts below.
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Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021.
Video: Prevalence of Long Term HCQ in Retinal Toxicity: Dr. Kathryn Dao (@KDAO2011 )
Dr. Kathryn Dao reviews abstract OP0133, "The Prevalence and Risk Factors of Retinal Toxicity Associated with Long-Term Hydroxychloroquine Use", presented at #EULAR2021.
https://t.co/tZyXQhZgLG https://t.co/x6AfItFWEU
David Liew
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On choosing an agent for MTX-IR RA:
"(at the end of talk) My short answer could have been... there's no right or wrong. It's still one of the dilemmas we have in the treatment of RA: choosing the right drug for the right patient" - @DanielAletaha
#EULAR2021 @RheumNow https://t.co/C45ey1SrA1
Jeffrey Sparks MD MMSc
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Results: MTX vs. PBO
✅Difference in least-squares mean ΔeGFR 0.93 mL/min/1.73m2 (p<0.001)
✅HR for kidney AE on safety labs: 0.73 (0.59-0.91)
✔️HR for kidney AE clinical events: 0.87 (0.56-1.36)
✔️4 vs. 8 severe kidney AEs (HR 0.50, 0.15-1.64)
HUR-BIO real life data, PsA pts started bDMARDs w/in 18 mo of dx vs almost 3x later in RA pts (tended to remain on csDMARDs.) This distinction may be explained by synthetic DMARDs on activity differences between the RA & PsA. Abstract #POS0633 #EULAR2021 https://t.co/VkkF28jm2f https://t.co/IkfGdZYNY3
Jeffrey Sparks MD MMSc
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🤜MTX safe from kidney perspective if baseline CrCl 40+
🤜Potential for immunomodulation to prevent/slow progression to CKD? Deserves dedicated studies @Nephro_Sparks
Which biomarkers could guide csDMARDs tapering in #RA patients in #remission? Dr Gul reported in a cohort study using a tapering protocol, 35% had relapsed. Risk score for sustained remission comprise IRC<2%, MSK-US PD=0 and RAQoL=<1 (AUC=0.89) #EULAR2021 #OP0182 @RheumNow https://t.co/y1Y6ug7f3w
Jeffrey Sparks MD MMSc
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How does MTX affect kidney function/adverse events? Pre-specified analysis of DBRCT: MTX 15-20mg/wk (n=2391) vs. PBO (n=2395) both with folic acid over median f/u 23 months
✅We demonstrated kidney safety of MTX
⚡️⚡️Also a *suggestion* of LESS decline in eGFR for MTX than PBO https://t.co/SZXloLRmnj
#POS0022 prosp study of CTZ pregnancies: 1392 preg w/1425 outcomes @UCBUSA database
88.4% live births, 10.5% preg loss, 0.8% still birth
2.4% congen malform (w/2.1% major)
Preg loss⬅️Crohn's, NSAIDS, MTX
Preterm labor⬅️GCs, maternal infx
⬇️birth wt⬅️RA & GCs @rheumnow #EULAR2021 https://t.co/qnNcDIz8Ge
#EULAR2021 and EULAR IQ
Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021.
https://t.co/BkHjhOUqNU https://t.co/4JS1yGiJHg
Aurelie Najm
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Serious infections and BioDMARDs: what is the confounding factor?
BSRBR-RA: 33,916 RA treated w/ BioDMARDs with 62,532 years of follow-up, 2036 SI. HR of SI no longer different among BioDMARDs when adjusted for the line of therapy! #OP0241@Rheumnow #EULAR2021 https://t.co/UG9WrXP7RD
Meral K. El Ramahi, MD
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2021 GRAPPA STRONG recs (cont'd):
*⃣Crohn's Dz & UC: TNFi (not ETN), IL12/23i
🚫strong rec against IL17i
2021 GRAPPA CONDITIONAL recs for:
*⃣ Uveitis: TNFi (not ETN), CyA
*⃣ Crohn's Dz & UC: IL23i, JAKi, MTX
OP0229 #EULAR2021 @RheumNow https://t.co/AWyKqSapWG
Lower ILD incidence in PsA than RA in a large Nordic registry
⭐️ No significant ⬆️ in ILD in those using MTX
Abs#OP0222
#EULAR2021 @RheumNow https://t.co/lgGhu1Hmd6
#OP0228 Phase 3 RCT on Risankizumab - KEEPsAKE 2 -PsA with 49% prior bDMARD 95% prior csDMARD: week 24 results
PE: ACR20 51% active vs 26% on PLC
PASI90: 55% active vs. 10% PLC
#EULAR2021 @RheumNow https://t.co/UkZLcXTNnq


