Mohammad A. Ursani MD, RhMSUS
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Updated #EULAR2020 guidelines on management of #lupus #nephritis #SLE #rheumatology #autoimmune #SLE https://t.co/zk2QXXRvTy
All News
k dao
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#EULAR2020 THU0268 Neuro-develp't in 60 children w/ SLE +APS mothers (n=38):
25% ADHD
93% recent memory delay (assc w/⬆️tetrahydrobiopterin level. p=0.01)
40% speech delay
39.4% maternal APS assc w/special needs education in offsprings age >2 yrs, p<0.05
@rheumnow
k dao
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#EULAR2020 Dr. V Ritschl:EULAR Task Force on Patient Adherance: 30-80% of pts do not adhere to Rx. resulting in ⬆️dz severity, pain, fatigue, depression, decreased in function, physical activity. HCPs should discuss adherance reg. & explore factors affecting adherance. @RheumNow
k dao
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#EULAR2020 Dr. M. Voshaar noted HCPs can improve patient Rx adherance by asking:
1. What are the pts goals w/treatment?
2. Are there barriers to obtaining and taking meds?
3. Do pts feel sufficiently involved in the shared decision making process? @rheumnow
Janet Pope
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ENbrel works in long term for the few people left on the drug at 10 yrs with SpA. Enormous dropout. If you are still on Rx for a decade you are in the minority. Drop out of TNFi in SpA mirrors RA & PsA @RheumNow @eular_org @CRASCRRheum @earlyarthritis #EULAR2020 https://t.co/dLS2fw5uRP
k dao
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#EULAR2020 THU0225 Results of a Retrospect UK study: Monitor SLE patients with Sm+Ro+RNP autoAb combo closely; these patients have a higher rate (90.6%) of developing LN within 5 years of diagnosis compared to those w/o Ab (55.8%), p=0.002. @RheumNow
David Liew
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#EULAR2020 - it's been a blast!
Thanks as always for everyone following the meeting on Twitter - the conversation on here has made the meeting for me!
It's been lots of fun covering the meeting for @RheumNow - look out for some videos out on https://t.co/j0ZwZujGBj next week 🙂 https://t.co/0bdQKsuoND
Dr. John Cush
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Your #RA patients in low disease or remission, do you maintain, reduce or stop DMARDs #EULAR2020
k dao
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#EULAR2020 Updated RA Mgmt Recc
Main points:
1. MTX 1st line (if contraind, then SSZ/LEF; NOT HCQ)
2. Add bDMARD/JAKi if 1st csDMARD doesn't work + poor Px
3. Use IL-6i or JAKi for pts who can only take monoRx and failed csDMARD
@RheumNow
https://t.co/AIXz2dEOrX
Dr. Rachel Tate
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Study in Norway reveals that the majority of the women w/ SpA were not treated with TNF inhibitors before or during pregnancy. Few on TNFi were continued on tx during pregnancy. #EULAR2020 @RheumNow https://t.co/t7B6pASeWQ https://t.co/BwU6RF5Qkn
Dr. Rachel Tate
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Sustained clinical response shown over the 10 yrs of this German study in r-axSpA and nr-axSpA pts treated with ETN. No new safety signals. Abstract #AB0660 #EULAR2020 @RheumNow https://t.co/KCMDyzHaSr https://t.co/yFSTgWqzBQ
Dr. Rachel Tate
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Switching TNFi to VDZ in pts IBD-related SpA associated w/ articular exacerbation of SpA in 1 out of 4 patients within the first 5 months. New-onset MEM is also observed in up to 15% of patients with IBD treated with VDZ. #EULAR2020 @RheumNow https://t.co/ZVjZC7hvxs https://t.co/d1RT3GzB2b
Dr. John Cush
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Study of the French registries for TCZ, RTX, ABA, compared the risk of GI perforations (GIP). GIP risk was higher with TCZ (vs RTX,ABA) but was largely due to TCZ increasing the risk of diverticulitis. #EULAR2020 #OP0022 https://t.co/MGGWiVh5Jv https://t.co/nC2NblYnGO
Dr. John Cush
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When starting IV Pegloticase in #Gout, Do you start a DMARD too? #EULAR2020
k dao
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#EULAR2020 Recc for irAEs w/ICI:
1. GC's ok, goal<10 mg/d, any csDMARD, bDMARD (TNFi/IL-6),🚫ABT xcept life-threatening myositis
2. Myositis beware bulbar signs: dysphagia, dysarthria, dysphonia: stop ICIs,⬆️GC, IVIG/PE
3. Don't test autoAbs b/f ICI Rx
https://t.co/P5jDgnjK94
Janet Pope
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Can you classify SLE by labs only but should you? Serology is part of criteria but why dx with only +ANA, +antiDNA and no other CTD characteristics. Would need cytopenias & RBC casts to think of lab dx of SLE OP0094 @LupusCanada @RheumNow @eular_org #EULAR2020 @CRASCRRheum https://t.co/Jr6SRr3HR1
Dr. John Cush
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Avacopan is as effective as steroids in ANCA Assoc Vasculitis – 330 pt RCT AAV Rx w/ RTX or CTX but randomized to prednisone or avacopan (C5aR antagonist). Avacopan=prednisone remission rates same (72% vs 70%) wk 26 & wk 52 (66% vs 55%). #EULAR2020 #OP0011 https://t.co/WIXJCYkxSb
Dr. John Cush
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Christos Koutsianas
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Do not be tempted to stop MTX or other DMARDs perioperatively! They probably help rather than harm #EULAR2020 https://t.co/jb4ZuZlqSu
Dr. John Cush
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RA pt not responding to a 1st biologic; what you predict in a Head to Head - Abatacept vs Upadacitinib?
