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Tocilizumab Efficacy in Giant Cell Arteritis Phenotypes

d Jack Cush, MD

A Spanish Collaborative Group study of Tocilizumab (TCZ) in Giant Cell Arteritis (GCA) demonstrated high efficacy regardless of the different vascular phenotypes treated. 

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Biosimilars Do Impact Biologic Drug Costs

d MedPage Today

Introduction of biosimilars for the rheumatology drug adalimumab, whose original branded version Humira has long been a blockbuster, appears to have led to a dramatic drop in net spending for these products -- even though biosimilars barely dented Humira prescription rates.

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ICYMI: Sex related differences in PsA

d Adela Castro, MD

Different factors are known to influence disease characteristics and outcomes in psoriatic arthritis (PsA).

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ICYMI: Beyond the Needle: Redefining the Assessment of Lupus Nephritis

d Akhil Sood, MD

Lupus nephritis is one of the most silent and severe manifestations of SLE. When not captured early, patients are at high risk of progressing to end-stage renal disease, which would require dialysis or transplantation. Renal biopsy remains the gold standard for diagnosis and disease classification. However, the procedure is invasive and very painful. Non-invasive measures are critical for early detection and continuous monitoring.

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ICYMI: Are Emulation Trials a Fantasy?

d Janet Pope, MD, MPH, FRCPC

Are emulation ‘trials’ helpful, despite the biases that occur with observational data, or do they truly mimic the results of randomized controlled trials (RCTs)?

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54K Peptic Ulcers Annually (12.13.2024)

d Jack Cush, MD

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com

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Rheumatoid Arthritis Boosts Risk for Some Types of Heart Failure

d Medpage Today

Rates of heart failure with preserved ejection fraction (HFpEF) were doubled in patients with rheumatoid arthritis (RA) relative to other people of the same age and sex, researchers found.

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1st MTX use in 242 Italian pts w/ chronic inflam arthritis (54% RA, 33% PsA, 16% UA). Overall, survival of MTX at 24 months was 60%, (40% @48 mos, 20% @96 mos). MTX survival in RA & PsA equal, but superior to UA (undiff. arthritis) https://t.co/g4pZpVmTnM https://t.co/gcKWriqfhG

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Serum IL-40 increased in RA (vs OA, SLE, Controls) and correlates with some clinical characteristics. IL-40 did not correlated w/ Dz activity, but was pos. assoc. w/ RA autoAbs, coagulation-related indicators, and decreased with TNFIi Rx. https://t.co/leBPKbNpf5 https://t.co/fHU8lcS4eW

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International Map of Axial SpA study surveyed 5557 axSpA pts (3231 Europe, 770 USA); mean 44 yrs old; 55% females. mean BASDAI was 5.4 (75% had active disease -BASDAI ≥4). Active Dz highest in S. Africa 87%, vs 68% in Asia. Active Dz assoc w/ active functional limitation,… https://t.co/j8CjuLHHjD https://t.co/tV9S3b7YCM
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Avacopan, a C5aR antagonist, for Rx of ANCA-Assoc GPA & MPA. Main warning for liver AE. In RCTs, abnl LFTs seen in 11.6-13.3% and 4.2% D/C drug for liver probs. Recent Japanese report of 22 AAV pts with AVACO Liver injury seen in 9 pts - Severe, incr total bilirubin in 4, 1 pt… https://t.co/LyuIQhwOoQ https://t.co/TAmQ9vph4V
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Although there is a bidirectional relationship betw pain and sleep, Sleep impairment more strongly predicts pain than pain does sleep. Addressing sleep disturbances is crucial, as it is linked to higher levels of disability, depression, pain-related catastrophizing.… https://t.co/pcFeCWSBCg https://t.co/0QlnbpKEbp
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CorEvitas registry study of 1823 psoriatic arthritis pts found that 11.1% fulfilled the fibromyalgia definition and 20.6% fulfilled the widespread pain definition. Factors assoc w/ FM: female, depression, anxiety, impaired function, BMI & #of comorbidities.… https://t.co/nDk8hPTlAu https://t.co/jnO5MijoGJ
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Safety of Acetaminophen in the Elderly New research, led by experts at the University of Nottingham, has found that repeated doses of paracetamol in people aged 65 and over, can lead to an increased risk of gastrointestinal, cardiovascular and renal complications.… https://t.co/rLchNTh6C8 https://t.co/y2DUx6TQR0
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Review of IgA Vasculitis (Henoch–Schönlein Purpura) - the freq of glomerulonephritis is higher in adults than children and tends to present more severely. Rx w/ 1st line steroids, Other agents: Colchicine, dapsone, MTX (Minor dz), CsA, tacrolimus, MMF (steroid sparing)… https://t.co/tB5fll3RfN https://t.co/knc7KesyRj
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Join us at RheumNow Live February 8 & 9 in Dallas, TX! Our incredible meeting will feature speakers like: Rheumatology Power Trio: Exploring RA Management in Older Adults, AI Innovations, and Multimorbidity Strategies Una Makris, MD, MSc Jeff Curtis, MD, MS, MPH Bryant… https://t.co/570WrI6RHT https://t.co/TTGtcNmWx7
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2024 Match results are in - Rheumatology- 287 matched, 99%: Top 6: 1. Cardi 99.8% 2. Cardio EP 98% 3. Endocrinology 98.4 % 4. GI 99.6% 5. Heme/Onc 99.7% 6. Rheum 99% https://t.co/UYnXc13VvQ https://t.co/kAZ4GACXkL

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Predicting Flares in Rheumatoid Arthritis Dr. Jonathan Kay interviews Dr. John Isaacs about abstract 1349, presented at the 2024 ACR Convergence meeting in Washington, DC. https://t.co/pM1AgPiRla https://t.co/0hP5y1JgPq

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Are we under-monitoring in scleroderma ILD? Dr. Janet Pope discusses abstract 0678, Patients with Interstitial Lung Disease Due to Systemic Sclerosis or RA Need Monitoring More Frequently Than Annually, and abstract 0706, Single Center Prospective Cohort of Systemic Sclerosis… https://t.co/GJRWGxUnh3 https://t.co/vtCOXGe4H8
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Dengue fever, a mosquitoborne viral illness, is increasing worldwide; during 2024, approximately 13 million cases have been reported in the Americas. 2010–2024, a total of 15,077 (38.6%) patients were hospitalized But the fatality rate is unchanged. 2023 DENV-3 recent outbreak in… https://t.co/BKrEmN4F6G https://t.co/WIXaPeex8Z
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