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SLE Conference Preview: progress in biologics
The pharmacology treatment including biologics, cellular-based therapies, and Bi-specific T-cell Engager (BiTE) in systemic lupus erythematosus (SLE) is a rapidly expanding field of research that provides excitement and optimism to both the patients and the physicians.
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From Fitbit to first diagnosis: AI is rewriting the RA playbook
Artificial intelligence isn’t a distant frontier anymore. It’s here, and it appears able to detect signs of rheumatoid arthritis, possibly before we can clinically detect it. Two studies presented at this year’s ACR meeting highlight just how close we may be to a future where algorithms flag disease before we can and monitor activity with minimal patient burden.
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Organ Specific Recommendations-ACR guidelines for Management of SLE by Dr Lisa Sammaritano. @RheumNow #ACR2025 https://t.co/ilKWG8CQbe
Dr M Nazibur Rahman, MD (Rheumatology) NaziburM ( View Tweet)
AI-enhanced MRI integrating STIR and T1-weighted MRI with BME data reflecting both inflammatory and structural changes, enabling the AI model to predict clinical diagnoses of axSpA with accuracy of 82%. Successfully identified axSpA patients who did not meet the ASAS criteria for https://t.co/dLlGj0ZFpj
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
Join us at 5pm CST for Day 1 #ACR25 recap! https://t.co/EwZSiPhysF
Dr. John Cush RheumNow ( View Tweet)
Plenary session at #ACR25!
#0772 When should we biopsy in SLE?
In pts with uPCR 0.25-0.49 g/g + LN predictors, 69% already had LN (many Class III/V). Low C3/C4 were most important factors.
0.5 g/g cutoff may delay diagnosis and treatment. Time to rethink thresholds? @RheumNow
Mrinalini Dey DrMiniDey ( View Tweet)
#LLM can be #virtual #tutor for
👇
#OSCE
RCT - better competence &confidence
#AI & #medical #education
AI trained to #tutor
Also grading OSCE #AI + human
@RheumNow @ACRheum #26S17 https://t.co/CzKoxyjpY8
Janet Pope Janetbirdope ( View Tweet)
Early, low level proteinuria is a harbinger in SLE. ~50% with elevated UPCR but <0.5 had actionable LN on early bx.
Risk factor = low c3/c4
Urine biomarkers promising
#ACRBest #ACR25 @RheumNow https://t.co/WuNPKeqeid
Links:
Brian Jaros, MD Dr_Brian_MD ( View Tweet)
#Pros and #cons of #AI
Need to know both
Need to assess AI #quality and #accuracy
‘Assume AI WILL be used’
JHausmann
By trainees, patients and medical personnel
Train #faculty re #AI
#ACR25 @RheumNow @ACRheum
#26S17 https://t.co/CvPDQPbueW
Janet Pope Janetbirdope ( View Tweet)
What's new in the Pre-RA world?
Slowly unraveling mechanisms and biology associated to transition from CCP+ asymptomatic pre-RA state to clinical RA
Here is my summary of a few abstracts presented at #ACR25 proposing biomarkers beyond the realm of clinical and classical
Aurelie Najm AurelieRheumo ( View Tweet)
From Dr. Petri at Plenary - even small amounts of proteinuria are a PROBLEM. Reduction of microalbuminuria by even 10% improves mortality! #ACR25 @RheumNow https://t.co/hjmH26vXIb
Brian Jaros, MD Dr_Brian_MD ( View Tweet)
#AI for medical use is fast moving
governance is Impt
Protect Privacy
Facilitate trainees to LEARN
Involve #IT, ethicists, users
‘We will enter a world where all we do medically is recorded’ J Hausmann said
#ACR25 @RheumNow @ACRheum
#26S17 https://t.co/zWjy4u99Yo
Janet Pope Janetbirdope ( View Tweet)
Topical therapies in cutaneous lupus - find the right level
Victoria Werth #ACR25 SLE guideline session @RheumNow https://t.co/o3gBuFkr4n
Links:
David Liew drdavidliew ( View Tweet)
#Medical #learners more optimistic re #AI than gen pop’n!
Tips
stress privacy
- pt info in AI goes to private company
All trainees will use #AI
Set boundaries - change eval where can’t use AI
only AI listening notes
👇
#cognitive #deskilling
#ACR25 @RheumNow @ACRheum
26S17 https://t.co/UzajaimOcG
Janet Pope Janetbirdope ( View Tweet)
For #SLE pleuropericarditis: recommendation intentionally tries to leverage use of colchicine/NSAIDs vs. GCs
But there are special situations where GCs are req’d:
> Concomitant active SLE
> CI to NSAIDs/Col
> Recurrent pericarditis
> Late pregnancy
> 💊interxns
#ACR25 @RheumNow https://t.co/sLL72t3Qhf
Links:
sheila RHEUMarampa ( View Tweet)
HIGH YIELD🚨Summary of Organ Specific Recommendations-ACR guidelines for Management of SLE by Dr Lisa Sammaritano. @RheumNow #ACR2025 https://t.co/ysSTKOz1ym
Gabriela Martinez Zayas, MD MartinezZayasMd ( View Tweet)
Year in Review: Regency Trial showed that LN pts given obinutuzumab achieved CRR at 76 wks (46.4%) vs. PBO.
Take note: the Regency trial did not evaluate the extrarenal effects of Obinutuzumab in #SLE, thats for a diff study.
#ACR25 @RheumNow https://t.co/WJssU1DbzZ
sheila RHEUMarampa ( View Tweet)
High-resolution ultrasound detected subclinical enthesitis in 44% of psoriasis patients without arthritis and 12% had PD positivity. Supports a preclinical PsA phase and use of MSUS to detect entheseal inflammation in both symptomatic and asymptomatic PsO patients for timely
Antoni Chan MD (Prof) synovialjoints ( View Tweet)
#ACR25 New ACR Non-Renal #SLE lifecourse Guideline. 3 strong recommendations:
- HCQ routinely unless contraindicated
- Taper GC to =< 5mg/d
- Escalate therapy in any organ system if refractory to initial therapy
*Organ-specific: Conditional recommendations only
@RheumNow https://t.co/w9rfcvwGHy
Md Yuzaiful Md Yusof Yuz6Yusof ( View Tweet)
Don’t fight #AI
#RCTs - #AI better at soft
Skills alone
Vs
#Medical input and AI as we tend to
Disbelieve the model & mess it up!
#LLM can accurately take a #history
Bottom line EMBRACE AI ?check it too
#ACR25 @RheumNow @ACRheum
#artificial #intelligence and #medicine
26217 https://t.co/22MYD4QqzH
Links:
Janet Pope Janetbirdope ( View Tweet)
