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An Alternative Pain Protocol Following Knee Replacement Surgery
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EurekAlert!
A study led by Vinod Dasa, MD, Professor of Orthopaedics at LSU Health New Orleans School of Medicine, reports that a novel surgical pain management strategy following total knee arthroplasty (TKA), or total knee replacement, provided pain relief without opioids.
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The Late Edition (2.24.2023)
Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com
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Periodontal Mucosal Breaks Trigger RA Disease Activity
Periodontal disease (PD) is more common in rheumatoid arthritis (RA), especially those with anti-citrullinated protein antibodies (ACPAs). RA activity has been linked to the severity of PD and mucosal inflammation.
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Metanalysis of 25 studies, betw 1985 - 2021, showed US average annual visits for RA=5.25 for US rheums (vs 3.3 ex-US) & 4.8 US non-rheums. SLE=3.24 & 12.3 for US non-Rheums. FM=1.8 for US rheums & 0.4 vs ex-US Rheums. Rheum Visits Decreased 1982 to 2019 https://t.co/WIXDXUCG60 https://t.co/s7W9gcd5dd
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Dr. John Cush RheumNow ( View Tweet)
5 Nordic register study of new b/tsDMARD starts in in PsA - 5659 ADA (56% biologic-naïve) & 4767 other b/tsDMARD (21% naïve) starts. ADA more often 1st line; newer b/tsDMARDsin biologic-experienced. 2nd line retention: ADA 65%, ABA 45%, Otez 43%. https://t.co/XKLiana6vB https://t.co/PotwYlYXto
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National study of 184,722 #RA pts (182 RISE sites) shows High % of socially deprived, high comorbidity, Medicaid- RA pts mainly in the south; <10% of Rheum practices cared for >50% of Medicaid RA pts. Moderate correlation betw comorbidity & Dz activity https://t.co/dsjH78cJqp https://t.co/U3l2m566d1
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Dr. John Cush RheumNow ( View Tweet)
Chest Pain & Fever
Lessons from the clinic, brought to you by https://t.co/4UQlqwujiR March 18 &19, 2023 - Dallas, TX
https://t.co/6iMT1Tt7KR https://t.co/owui66FMPJ
Dr. John Cush RheumNow ( View Tweet)
Comparing ACR21 vs EULAR22 RA Guidelines
https://t.co/dLtEaUBTKM https://t.co/Rang58z2N2
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Overview of Juvenile idiopathic arthritis (JIA) assoc uveitis (JIA-U) seen in 10–15% ofJIA pts, higher risk w/ ANA+, oligo-JIA, f& onset ≤6 yrs age. Rx options: topical steroids, MTX, ADA, INFLX, RTX and TCZ (review of TCZ in JIA-U) https://t.co/fqQ8ZhSLCM https://t.co/1GkUpCqJoE
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Dr. John Cush RheumNow ( View Tweet)
Survey of 300 Rheums, GI, Derms - concerns w/ new biosimilars
- majority say economics arent favorable to switch to biosimilar
- Yet majority "very to somewhat” comfortable w/ biosimilars
- US: Slow biosimilar uptake due to disappointing costs https://t.co/DOhrfELssY https://t.co/f2iy9igq5d
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Im not sure this was necessary but - a metanalysis of 10 RCTs w/ 847 OA patients shows colchicine use in osteoarthritis had no efficacy as far as pain reduction (vs control; SMD= 0.17) & no improvement in function (SMD, - 0.37) https://t.co/pDR0XO6vCg https://t.co/o8yYByBj8I
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Specific ACPAs and Autoantibodies Lead to RA-Associated ILD
https://t.co/AuTDGt8gYJ https://t.co/Q1rKdxkbLZ
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Vision Loss with ANCA-Associated Vasculitis
Shelley K. Dhillon, MD, presents her poster at RWCS 2023.
https://t.co/wE76hDJq4y https://t.co/pbuH4SBTSp
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Subscribe to the RheumNow podcast on your favorite podcast app to get automatic downloads of the latest content. Listen in the car, airplane, anywhere! Rate, review and subscribe!
https://t.co/3EENe1VFKl https://t.co/V0X5BAtDBq
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Comparing ACR21 vs EULAR22 RA Guidelines
https://t.co/sqYLrg9wC2 https://t.co/y3a8yDVQhP
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Dr. John Cush RheumNow ( View Tweet)
QD Clinic - Arthralgia, Raynaud's & Anemia
https://t.co/2H9EAZvP2s https://t.co/Bcerjoucjf
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A Singular Case of Plural Effusion
Shashank Suresh, MD, presents his poster at RWCS 2023.
https://t.co/xAR2WcK9MN https://t.co/KVGM9ri3cj
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Which Meds are Best for Acute Low Back Pain?
Acute low back pain (LBP) is a common cause of disability. An analysis in the Journal of Orthopaedic Research examined which non-opioid drugs are best for treating this condition.
https://t.co/StteWi87Y5 https://t.co/9CvYIqx5Cv
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Dr. John Cush RheumNow ( View Tweet)
New Drug Formulations – For Patients or Profits?
Wang et al in JAMA Network Research Letter, reviewed Medicaid expenditures on ADA, noted that the introduction of the citrate-free formulation cost an extra $4.4B to Medicaid from 2014-2021.
https://t.co/W1sst12GJK https://t.co/OYLkSHEQ2X
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Dr. John Cush RheumNow ( View Tweet)
32 men w/ B27+ #AS (Rx NSAIDs, BASDAI ~5.3) underwent exercise training (10d, 60min) w/ or w/o Pre-Rx w/ whole-body cryotherapy (WBC). WBC had significant drops in hsCRP, sP-Selectin, sVCAM-1, neopterin & signif decreases in BASDAI, BASFI, pain intensity https://t.co/8bmjTS4VOk https://t.co/ajrD8Z7C8v
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Dr. John Cush RheumNow ( View Tweet)
