All News

PSO.Palmoplantar.jpg

Biologic Use and the Risk of Serious Infection in Psoriasis Patients

d Jack Cush, MD

National Health Data from France examined biologic use in patients with moderate to severe psoriasis, and found the risk of serious infections (SIE) to be increased with some biologics (infliximab and adalimumab), but not others (etanercept, ustekinumab IL-17 and IL-23 inhibitors or apremila

Read Article
lupus_0.jpg

BEAT-LUPUS: Sequential Belimumab After Rituximab in SLE

d Jack Cush, MD

The Annals of Internal Medicine reports that targeting B-cells in refractory systemic lupus erythematosus (SLE) with sequential belimumab after rituximab may significantly reduce dsDNA antibody titers and lessen the number of future severe flares.

Read Article
Clot.DVT_.VTE_.blood_.jpg

Rheumatoid Arthritis Thrombotic Risk Influenced by DMARD Choice

d Jack Cush, MD

RA patients have an increased risk of venous thromboembolism (VTE) related to disease activity and inflammation, yet a large real-world study of older RA patients shows methotrexate to be associated with a 2-fold increased VTE risk (compared to hydroxychloroquine).

Read Article
ankle,xray

Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis

d Jack Cush, MD

A controlled trial of intra-articular platelet-rich plasma (PRP) injections into the ankle of osteoarthritis (OA) patients failed to improve ankle symptoms and function when compared to placebo injections - yet another trial showing that intraarticular injections are seldom beneficial.

Read Article
Hip

Pfizer/Lilly Pull Tanezumab Development

d Jack Cush, MD

Today, Lilly and Pfizer announced their global clinical development of the NGF inhibitor, tanezumab, has been discontinued due to recent negative opinions from the EMA and FDA advisory committee.

Read Article
liver,hepaitis,pink,gb

New Hope for NonAlcoholic Fatty Liver Disease

d Jack Cush, MD

The current issue of the NEJM has two articles on nonalcoholic fatty liver disease (NAFLD also called NASH - nonalcoholic steatohepatitis), one dealing with the prognoses, outcomes and mortality of NAFLD and another prospective and promising interventional trial in NASH patients. 

Read Article
syringe,needle,vaccine

How Should Patients With Autoimmune Diseases Approach COVID Vaccination?

d MedPage Today

Healthcare is a personal and individualized relationship between a provider and patient. Each patient is treated according to their particular symptoms and personal health characteristics.

Read Article
Rheumatoid Arthritis Thrombotic Risk Influenced by DMARD Choice https://t.co/gOLhO2aNOo https://t.co/FwKP3slExA

Links:

Dr. John Cush RheumNow ( View Tweet)
QD Clinic - The Thyroid Lump QD Clinic is sponsored by https://t.co/V10S4oE43V's coverage of #ACR21 https://t.co/J5YkJmaNea https://t.co/UidG4dT1JJ

Links:

Dr. John Cush RheumNow ( View Tweet)
Platelet-Rich Plasma Injections Fail in Ankle Osteoarthritis https://t.co/Fmf8f2C3Y4 https://t.co/9ZJe2jAYVw

Links:

Dr. John Cush RheumNow ( View Tweet)
Sign up today to receive #ACR21 news and select topic emails throughout the conference. #RheumNow https://t.co/riyAnrRHhX https://t.co/MkoDsw34D0

Links:

Dr. John Cush RheumNow ( View Tweet)
While psoriasis and Psoriatic arthritis patients have an increased risk of fractures, there is no increased risk of osteoporosis or osteopenia. Data from 12 studies an 199 million individuals https://t.co/G4Ya7CUWYX

Links:

Dr. John Cush RheumNow ( View Tweet)

Systematic review of dsDNA studies (byfluorescence immunoassay) included 1977 total patients, 47% with SLE == over all dsDNA had >90% for specificity and a pooled specificity of 94.7% (95% CI 91.67%-96.67%) https://t.co/Nk8h9fDYpE

Links:

Dr. John Cush RheumNow ( View Tweet)

Methotrexate is the most often-studied treatment and has best clinical outcomes in children and adults with localized scleroderma en coup de sabre. Metanalysis of 34 articles, only 4 RCTs, but 24 case reports. More research needed. https://t.co/fSEvDw2pge

Links:

Dr. John Cush RheumNow ( View Tweet)

Register now to receive #ACR21 news and select topic emails throughout the conference. https://t.co/riyAnrRHhX https://t.co/ufGxXnbtoG

Links:

Dr. John Cush RheumNow ( View Tweet)
Rheumatic pts admitted to ICU, #SLE is most common & Sepsis most common reason. 80 ARD pts adm to ICU: Dx were SLE (42%), RA (26%), vasculitis (12%) FOR Sepsis (31%), (10%) CHF (10%). 20% died in ICU, 5% 30d after ICU, 7.5% w/in 1 yr https://t.co/lX0m3vOukI

Links:

Dr. John Cush RheumNow ( View Tweet)

Short (3 min) walks intstead of sitting benefits RA w/ anticytokine effect (TNF, IL1RA), improved glucose, c-peptide, insulin. Crossover study 15 RA women who had 1) prolonged sitting, 2) 30-min mod-vigor exercise or 3) 3-min of light walking every 30 min https://t.co/36AnhHL9OI

Links:

Dr. John Cush RheumNow ( View Tweet)

New Download Available! FDA EUA for Baricitinib in COVID https://t.co/yTQLb7DDvR https://t.co/n9Npg0Pq5q

Links:

Dr. John Cush RheumNow ( View Tweet)
Watch: QD Clinic - Severe Arthritis Numbers QD Videos are brought to you by RheumNow's upcoming coverage of ACR 2021 https://t.co/QgBL4dnCk7

Links:

Dr. John Cush RheumNow ( View Tweet)

From March to Dec 2020, study of 116K COVID pts saw monthly rates of hospitalization (105/100K), ICU admits (20/100K), & death (12/100K) -peaked 12/20. Highest w/ age >65yrs, hispanics, blacks. Remdesivir incr 1.7% to 54%; Steroids 19% to 74.2% https://t.co/5pzu74YIz6

Links:

Dr. John Cush RheumNow ( View Tweet)

×