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Lymphoma in RA: Disease Activity Matters

d MedPage Today

Among patients with rheumatoid arthritis (RA), the strongest risk factors for the development of lymphoma were disease activity and severity, French researchers found.

In a multivariate analysis, having a high Disease Activity Score in 28 joints (DAS28) at baseline conferred twice the risk for lymphoma, with an odds ratio of 2.09 (95% CI 1.41-3.38), according to Gaetane Nocturne, MD, of Hôpital Bicêtre in Ile-de-France, and colleagues.

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COVID Breakthrough Infections in Rheumatic Patients

d Jack Cush, MD

Analysis of records from the Mass General Brigham healthcare system in the Boston area, shows that breakthrough infections (after receiving SARS-CoV-2 vaccines) in patients with systemic autoimmune rheumatic diseases (SARDs) are not uncommon, and may be severe or fatal.

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Diagnostic Delay in Half of Psoriatic Arthritis Patients

d Jack Cush, MD

 A Mayo Clinic/ Olmsted County study of psoriatic arthritis (PsA) patients has shown that more than half (55%) of PsA patients had a diagnostic delay of > 2 years, and that this delay has not improved over time.

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ICYMI: The Greatest Rheumatologist - Part II

d Jack Cush, MD

Wow! I hope you read part I of yesterday's “Greatest Rheumatologist” article.  So many big names and yet, other names and stories that were equally inspirational.



If you read the comments of the part I article you can clearly see several themes emerge.

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JAMA: In women with spontaneous abortions, COVID-19 vaccine exposure was not increased compared with women without Spont Ab (ongoing pregnancy). COVID-19 vax given to 8.0% ongoing pregnancy vs 8.6% spont ab (adj OR 1.02) https://t.co/wEeaMR98Mf

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Dr. John Cush RheumNow ( View Tweet)

UK study shows PreClin RA, Establ #RA 1) have increased bowel permeability; 2) gut permeability worsens w/ activity; 3) gut-permeability markers not affected by treatment; 4) in a RA Mouse model-blocking gut permeability ameliorates arthritis https://t.co/HZNl56cQnn

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Dr. John Cush RheumNow ( View Tweet)

A Mayo Clinic/ Olmsted County study of psoriatic arthritis (PsA) patients has shown that more than half (55%) of PsA patients had a diagnostic delay of > 2 years, and that this delay has not improved over time. #RheumNow https://t.co/6HIImOQ5nc https://t.co/uIjWSYt4JH

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Dr. John Cush RheumNow ( View Tweet)
Dr. Cush is joined by rheumatology colleagues to discuss impressions and impact of the 9/1/21 FDA Drug Safety Communication to physicians regarding new label changes. #RheumNow https://t.co/F37SCpJnsW https://t.co/uhdOjFo0yP

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Dr. John Cush RheumNow ( View Tweet)
FDA has issued 510(k) (medical device) clearance for the marketing of an artificial intelligence algorithm from Radiobotics to diagnose #OA knee - "RBknee™" can identify osteophytes, subchondral sclerosis, joint space narrowing & width https://t.co/cY111NH69w

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Dr. John Cush RheumNow ( View Tweet)

ICYMI: The Greatest Rheumatologist - Part II #RheumNow https://t.co/NBNsmSxxcW https://t.co/n2f01vnugD

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Dr. John Cush RheumNow ( View Tweet)
ICYMI: The Greatest Rheumatologist - Part I Who is the greatest rheumatologist? What makes for a great rheum? Is it clinical acumen, scientific achievement, educational prowess or years of unrivaled service or mentoring? #RheumNow https://t.co/aNKnYtlN4I https://t.co/FBNXuKnbiA

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Dr. John Cush RheumNow ( View Tweet)
Causes of DYSGEUSIA (metallic taste): - Antibiotics (clarithromycin, metronidazole tetracycline), Allopurinol, captopril, Lithium, Methazolamide, Metformin, Lunesta and more... heres a video discussion on this. https://t.co/FphprLh1Sf https://t.co/1wkjQxA9UZ

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Dr. John Cush RheumNow ( View Tweet)

Strept pneumoniae vaccinations are underutilized. A Univ of Pittsburgh project utilized EMR reminders to prompt vax w/ Prevnar/PCV13 & Pneumovax/PPSV23. PPSV23 vax increased 28% to 62% and either PPSV23, PCV13 incr 50% to 77% using EMR https://t.co/DO9WnyBHI1

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Dr. John Cush RheumNow ( View Tweet)

MMWR: COVID-19–hospitalization rates in kids & adolescents rose 5-fold late June–mid-Aug 2021 (w/ rise of Delta variant). Hospitalization rates were 10 times higher among unvaccinated than fully vaccinated adolescents. https://t.co/Qt5lj3Ycxb

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Dr. John Cush RheumNow ( View Tweet)

In case you missed it— Booster Shots for Rheumatology Patients on Immunosuppressive Medications https://t.co/dIzrv3B12u https://t.co/nGIUNcqNTf

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Dr. John Cush RheumNow ( View Tweet)
https://t.co/wM1iRxtHvk The interleukin-6 inhibitor, tocilizumab (TCZ), was studied in a cohort of difficult systemic sclerosis (SSc) and was shown to be effective in refractory joint and skin disease with good long-term retention rates and disease stabilization. https://t.co/UBjpHUlb1l

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Dr. John Cush RheumNow ( View Tweet)
Musculoskeletal sequelae/complications in adults following ICU admission studied by metanalysis of 32 studies. Muscle problems, pain (shoulder pain) predominated. Weakness in 29%, Chronic pain 34%, neuromuscular impairment 51%. https://t.co/FpqDvRDtVq

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Dr. John Cush RheumNow ( View Tweet)

Our latest @MassGenBrigham rheumatology COVID collaboration with @zach_wallace_md #preprint to share quickly. 16 confirmed breakthrough infections in rheumatic patients since vaccine EUAs in US. 15 symptomatic, 6 hospitalized, 2 deaths https://t.co/atixfBcEbn

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Jeffrey Sparks MD MMSc jeffsparks ( View Tweet)

Our @MassGenBrigham @zach_wallace_md rheum COVID paper on breakthrough infections is out now in ARD https://t.co/zOZqF0ecaG

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Jeffrey Sparks MD MMSc jeffsparks ( View Tweet)

Pleased to share our study in A&R investigating rheum evaluation, immunomodulator use, and predictors of rheumatic immune-related adverse events (irAEs) after immune #checkpoint inhibitor use for cancer, led by @BusselKiki @BrighamResearch @DanaFarber https://t.co/6rnSfd08FB

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Jeffrey Sparks MD MMSc jeffsparks ( View Tweet)

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