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RheumNow Podcast - Speak Up! (6.18.2021)

d Jack Cush, MD

Dr. Jack Cush talks on education, engagement and the challenge of speaking up, if not first!

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Do B-cell targeted therapies still have a place for the treatment of Sjogren’s?

d Md Yuzaiful Md Yusof, MRCP(UK), PhD

B-cells play a major role in the pathogenesis of primary Sjogren’s syndrome (pSS) through antibody-dependent and antibody-independent functions, as well as evident by progression to B-cell malignancies/lymphoma. Hence, targeting B-cell is attractive. Despite efficacy of B-cell depleting therapy with rituximab in Phase II trials and case series, it failed to meet its primary endpoint when investigated in two Phase III trials. It is worth noting that the primary endpoint used in both trials was a subjective measure. Post-hoc analyses however showed greater improvement in objective measures such as salivary flow rate and salivary gland ultrasound score in RTX-treated group vs placebo.

Therefore, do B-cell targeted therapies still have a place for the treatment of pSS?

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yes, no, maybe

Reader beware! Interpretation of effectiveness & safety of JAKi vs bDMARDs in real world data

d Janet Pope, MD, MPH, FRCPC

Multiple studies compared effectiveness, retention and/or safety of biological DMARDs (bDMARDs) and JAK inhibitors (JAKi) at EULAR 2021.

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EULAR 2021 – Day 4 Report

d Jack Cush, MD

It's been nearly two weeks since EULAR 21 ended. There were several presentations on the last day; notably, the late breaking abstracts and others. Here are a few of my favorites from Day 4, the final day of the meeting.

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Don't Kill the Krill! Dr. Kathryn Dao ( @KDAO2011) reviews abstract POS0276 regarding the efficacy of krill oil in knee OA, presented at the virtual EULAR 2021 meeting. https://t.co/gX2hivyCs2 https://t.co/QaU7A7gM8j

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Watch: Lupus and the Economic Burden of Mental Health https://t.co/Ag3oz6U4mF https://t.co/cA5LmGRImf

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Should we treat to target ourselves? Dr. David Liew ( @drdavidliew ) shares learnings from #EULAR2021. https://t.co/divGxNku6a https://t.co/UBBH0QehY1

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Serious Infection Risk from the Filgotinib Drug Development Program Dr. Paul Studenic talks with Dr. James Galloway about abstract OP0126 presented at the virtual EULAR 2021 meeting. https://t.co/ymd8odsjAD https://t.co/d9fXGdmgOn

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What's the impact of RA on male fertility? Dr. Aurelie Njam shares new data provided at #EULAR2021. https://t.co/AHwhyLiwD0 https://t.co/pFKoADZ2sh

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Popular article: Best Interventions for Gout Flares https://t.co/duhEHJG9eY https://t.co/tJRwuMPhUR

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Is there a correlation between Vitamin D in RA? https://t.co/QXYVsa5jzP https://t.co/bH5OtL7Dig

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Watch: Sex Differences in Autoimmune Disease Susceptibility: Drs. Yusof and Robinson https://t.co/rvva90SQfg https://t.co/evYgTUCS1V

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RA ILD: Stepping out of the shadows Interstitial lung disease (ILD) is a common complication of rheumatoid arthritis (RA) with up to 8% of patients affected with clinically significant ILD. https://t.co/BaoqQLKR5C https://t.co/duIqHVfCAa

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Our "Best of EULAR" podcast is available for download. https://t.co/dOqNum7nFr https://t.co/WW8wJUKOj7

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When should you use a JAK inhibitor in RA? Dr. Janet Pope ( @Janetbirdope ) shares #EULAR2021 presentations. https://t.co/qF2tjQXLk1 https://t.co/AqJ1dMWV3t

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How do we measure success in lupus? Dr. Kathryn Dao ( @KDAO2011 ) discusses abstract OP0296, "The 2021 DORIS Definition of Remission in SLE - Final Recommendations From an International Task Force", presented at the #EULAR2021 meeting. https://t.co/7thqrfIqnL https://t.co/iXKfcbtDfv

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Ten Things to Tell Patients About Diet and Rheumatic Disease: Dr. Eric Dein ( @ejdein1 ) https://t.co/q2Mc1gLZig https://t.co/iV5JO8m5Sv

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Nr-axSpA vs axSpA — does it matter? Dr. Meral El Ramahi ( @MeralElRamahiMD ) reviews the panel from #EULAR2021. https://t.co/pfYvfsCbiA

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We review some of the EULAR Day 2 panels on our podcast. Download wherever you get your podcast. https://t.co/ShNhXGoCP1 https://t.co/hklqH3aiL7

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During Day 2 there were great sessions devoted to RA, spondylarthritis, fatigue and more. We've compiled some of the highlights. https://t.co/NbBqPbbiUy https://t.co/FvsOhKtrHi

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