Bidirectional Association Between Uveitis and Psoriatic Disease Save

A Danish population, claims-based study studied the the associations between 74,129 patients with incident psoriasis and 13,114 with incident uveitis between 1997 and 2011. Patients with mild psoriasis were 38% more likely to be diagnosed with uveitis (adjusted incidence rate ratio =1.38 (1.11-1.70 [P = .02]), and higher rates seen in severe psoriasis (1.40 (0.70-2.81 [P = .34]), and psoriatic arthritis (2.50 (1.53-4.08 [P < 001]). The subset of patients with psoriatic spondylitis (n = 294) had a more than 8-fold increased risk ((8.35 [2.09-33.38]) for uveitis. (Citation sourcehttp://buff.ly/1IX2M2r).

Conversely, Danish patients diagnosed with uveitis had a higher risk of mild psoriasis, with IR ratios (95% CIs) of 1.59 (1.32-1.91 [P < .001]) for mild psoriasis, 2.17 (1.40-3.38 [P < .001]) for severe psoriasis, and 3.77 (2.66-5.34 [P < .001]) for psoriatic arthritis, respectively.

The authors believe “The bidirectional relationship between psoriasis and psoriatic arthritis and uveitis suggests a shared pathogenic pathway."