Increasing Age May Increase Miscarriage Risk in RA Save

At EULAR 2015, Brouwer and colleagues reported on their cohort of 162 evaluable pregnancies in 239 Dutch women enrolled during 2002-2010 in the nationwide Pregnancy-Induced Amelioration of Rheumatoid Arthritis (PARA) study – a large prospective cohort of pregnant RA patients. They had a mean age of 32.3 years and a mean RA duration of 4.9 years. Overall, 49.4% were nulliparous and 13.6% had suffered a previous miscarriage.

Among the 162 pregnancies, 28 (17.3%) miscarriages occurred (half at weeks 5-9); a rate similar to the normal population. Logistic regression analysis showed only a trend toward higher miscarriage rates with increasing age (OR, 1.12; P = .065 per year of age increase) and ACPA positivity (OR, 2.47; P = .092).