Skip to main content

Risk Factors for Pulmonary Hypertension in Lupus

Mar 11, 2016 1:29 pm

Fidler and colleagues from Toronto have recently shown that pulmonary disease is common in lupus, as they found 56% of their patients with abnormal pulmonary assessments.  They found 12% with pleural disease, 11% with interstitial lung disease, 10% with shrinking lung syndrome and 5%  with pulmonary arterial hypertension (PAH).  (Citation source http://buff.ly/1SGqXVX)

Researchers from the Peking Union Medical College Hospital have studied PAH in systemic lupus erythematosus (SLE) using a case-control study design.  They identified 111 right-heart catherization confirmed SLE-PAH patients with a mean onset age of 34.6 years and an average lupus duration of 5 years. They found nearly half of patients were WHO Fc I-II, all were treated with immunosuppressants, and 65% took PAH-targeted therapy.

This study confirmed 2 independent risk factors for PAH that have been previously reported: A) pericardial effusion (OR = 21.290); and B) anti-RNP antibody (OR = 12.399).  They also identified 6 other independent variables that were significantly associated with PAH in SLE patients: 1) SLE duration; 2) interstitial lung disease; 3) not having an acute rash; 4) anti-SSA antibody; 5) SLEDAI ≤ 9; and 6) ESR≤20 mm/h and uric acid > 357 μmol/L. This study also showed that PAH-SLE patients usually diagnosed earlier have less disease severity than patients without PAH.

Disclosures
The author has no conflicts of interest to disclose related to this subject

Add new comment

If you are a health practitioner, you may to comment.

Due to the nature of these comment forums, only health practitioners are allowed to comment at this time.

×