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Scleroderma/Raynauds

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Methotrexate Monitoring (5.13.2022)

May 13, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. Bad news for digitial ulcers in Systemic sclerosis, Readmissions in Lupus and Thrombocytopenia in APL patients.




  1. Risk factors for readmission among 132,400 #SLE hospitalizatiions included

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Systemic Sclerosis patients with Digital Ulcers used significantly more healthcare resources per year. Study of 104 SSc pts; w/ DU's had more severe disease, more tests, More HCP/Rheum visits, etc (p˂0.05) https://t.co/wWvrOye92c https://t.co/HsZfSrf5CV
Dr. John Cush @RheumNow( View Tweet )
May 13, 2022
Patient,instruction

Making You the Expert of You! (Smart Rules for Patients)

May 10, 2022

You’ve scheduled an appointment with your medical provider - how do you make the most of it? We've gathered these tips and suggestions to share with patients.

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$30 Billion and Counting (4.29.2022)

Apr 29, 2022

Dr. Jack Cush reviews the news and journal reports and takes viewer questions this week.

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Pregnancy outcomes in systemic sclerosis (SSc) studied in 154 pregnancies from SSc, SLE, APS, & controls (2008 to 2019). Adverse Preg Outcomes APO significantly higher in SSc vs HC (61% vs 10%) w/ more miscarriages, preeclampsia, SGA & preterm births https://t.co/P3uksmJy6V https://t.co/nTtgwjdGgL
Dr. John Cush @RheumNow( View Tweet )
Apr 28, 2022
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Male vs. Female Responders (4.15.2022)

Apr 15, 2022

Dr. Jack Cush reviews the news and journal Reports from the past week on RheumNow.com - including fellowship COVID-19 concerns, the limits of T2T in gout and the real odds of RA remission with your first biologic. 




  1. Downward Effects! Real world data from 22,934 UK #RA pts

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Cell has a novel analysis using single-cell analysis of skin/blood from 56 controls & 97 diffuse systemic sclerosis pts, finding stromal abnormalities in LGR5+-scleroderma-assoc fibroblasts (ScAFs). ScAFs are decreased early & progressively https://t.co/Khxejd1fnq https://t.co/OrMAJnPTZt
Dr. John Cush @RheumNow( View Tweet )
Apr 11, 2022
cancer, melanoma, metastatic, cell

Increased Cancer Risk with Autoimmune Disorders

Mar 31, 2022

The incidence and mortality of cancer among autoimmune diseases (AID) was studied in a large Chinese cohort, demonstrating that while onset time and risks vary, there is an increased risk of malignancy in AID.



The cohort included 8,120 AID patients from a national tertiary referral

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A case–control study from Kaiser, compared obstetric complications in women who later developed Systemic Sclerosis (n=17) vs non-SSc controls (170). Obstetric complications higher in later SSc (71 v 50%) (HTN, PROM, IUGR, NICU, preterm births) https://t.co/4Y4eGuCFJi https://t.co/R4vw90bba4
Dr. John Cush @RheumNow( View Tweet )
Mar 29, 2022
ICYMI: Swedish study found 1774 systemic sclerosis (SSc) pts in 2015 w/ median age 65 yrs (84% women) = prevalence=22.7 per 100,000 . Incidence (2004-2015) was 11.9 per 1,000,000 PYs - incidence remained stable; F were 5x more common than M. https://t.co/NPZUg4CEjA https://t.co/V3H381KpHU
Dr. John Cush @RheumNow( View Tweet )
Mar 26, 2022
ICYMI: Good review of Diagnosis and Treatment of Pulmonary Sarcoidosis in JAMA. - Lung progression (in only 10%) assoc w/ 12-18% 5yr mortality - Sx Sarcoid w/ Lung: start Pred 20 to 40 mg/d for 2 -6 wks - Steroid sparing w/ MTX, AZA or TNFi https://t.co/Ue4V1uAhRF https://t.co/5ap3bPzoNk
Dr. John Cush @RheumNow( View Tweet )
Mar 12, 2022
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Diagnostic Delay in Axial Spondyloarthritis (2.25.2022)

Feb 25, 2022

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week, rheumatologic problems incited by respiratory infections, air pollution and how you live, now where you live.




  1. Diagnostic delay in axial spondyloarthritis? Systematic review

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Late Onset Scleroderma Renal Crisis: A Case Control Analysis - Dr. Yoon Qiu at RWCS 2022 https://t.co/G1M7Lzhk7P https://t.co/hPRL8WFdUf
Dr. John Cush @RheumNow( View Tweet )
Feb 21, 2022
Using whole gut scintigraphy & gastric emptying studies on 97 systemic sclerosis pts, researchers found 35% had gastroparesis, and these pts also had abnormal transit thru out the GI tract. High anti-CENP-B titers assoc w/ slower gastric emptying https://t.co/lQgQe5Uo9H

Dr. John Cush @RheumNow( View Tweet )

Feb 21, 2022
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RheumNow Podcast - RWCS 2022 Roundup (2.19.2022)

Feb 21, 2022

Drs. Jack Cush and Artie Kavanaugh review the highlights of the RWCS (Rheumatology Winter Clinical Symposium) from Maui.


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Nailfold Capillaroscopy doesnt have to be expensive: use handheld Carson Microbrite (~$10) 10x or 20 x handheld microscope (w/ KY gel) to evaluate #Raynauds #scleroderma https://t.co/8AMsEnaiir https://t.co/JZO0s8xbXA https://t.co/scJTBOD7OS #RWCS2022

Dr. John Cush @RheumNow( View Tweet )

Feb 19, 2022
Future considerations and treatment directions in systemic sclerosis per Dr Steen. #RWCS2022 @RWCSmtg https://t.co/FaJaJ9G5lU
Dr. John Cush @RheumNow( View Tweet )
Feb 18, 2022
Subsets of scleroderma defined by autoantibodies. #RWCS2022 @RWCSmtg https://t.co/ywe0yrHmWd
Dr. John Cush @RheumNow( View Tweet )
Feb 18, 2022
Many failed clinical trials in Scleroderma in the past. #RWCS2022 @RWCSmtg https://t.co/2PBfHAnqWu
Dr. John Cush @RheumNow( View Tweet )
Feb 18, 2022
Scleroderma ANA associations thru the ages. Dr. Virginia Steen @RWCSmtg #RWCS2022 https://t.co/U64gpnCgS8
Dr. John Cush @RheumNow( View Tweet )
Feb 18, 2022
Dr Virginia Steen at #RWCS2022. On scleroderma lung Dz that worsens outcomes https://t.co/n7IV8UVI2N https://t.co/kLmiKiseur
Dr. John Cush @RheumNow( View Tweet )
Feb 16, 2022
2021,year

2021 Rheumatology Year in Review

Jan 08, 2022

Our top 10 list of advances, game-changers, worries and those better medical practices that evolved during 2021.

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PSS.scleroderma.arthritis.contractures

Autoantibody Associations in Systemic Sclerosis

Jan 04, 2022

Analysis of two large cohorts of systemic sclerosis (SSc) patients shows a signfiicant minority of patients to have autoantibodies typical of rheumatoid erosive arthrits, but their presence in SSc patients was associated with unique manifestations of SSc. 



Overall 448 SSC patiens were

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Lungs ILD

Best of 2021: Actemra FDA Approved for Systemic Sclerosis Interstitial Lung Disease

Dec 21, 2021

Genentech announced March 4th that the US Food and Drug Administration approved tocilizumab (Actemra) for the treatment of Systemic Sclerosis-associated Interstitial Lung Disease (SSc-ILD), specifically indicated for slowing the rate of decline in pulmonary function in adults SSc-ILD.

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Indications Awaiting (12.17.21)

Dec 17, 2021

There's good news and bad news in rheumatology fellowship matching for 2022.  There's also new FDA approvals and indications, but a new serious safety warning has arisen from the CDC about the J&J COVID-19 vaccine. 

Dr. Jack Cush reviews the latest news, journal reports, regulatory

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