Scleroderma/Raynauds

NEJM Case: A 29-year-old woman with SLE presented to the dermatology clinic with 2-weeks of itchy, painful rash on her nose and hands that came on with cold weather. What do you think? https://t.co/NvaM4mVJWd https://t.co/QFtC47ZOv9

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Dr. John Cush @RheumNow( View Tweet )
Best Rheumatologists (7.19.2024) Dr. Jack Cush reviews the news and journal reports of interesting, including irAE, pollution and Psoriasis, microwave therapy, scleroderma without scleroderma that only the best rheumatologists could discern. https://t.co/2Tkdat6CXv https://t.co/1lOfbgNZvn

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Dr. John Cush @RheumNow( View Tweet )
Updated EULAR Recommendations on the Treatment of Systemic Sclerosis Medscape has published an overview to the 2024 updated recommendations for the treatment of SSc presented in Vienna at EULAR 2024. https://t.co/rmBIfNzJcu https://t.co/uZ2JUdsecZ

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Dr. John Cush @RheumNow( View Tweet )
Systemic sclerosis sine scleroderma Systemic sclerosis sine scleroderma (ssSSc), which accounts for nearly 10% of systemic sclerosis (SSc) patients and was first described in 1962, is a subset of SSc. https://t.co/5NMykTHEtK https://t.co/JNo27zaTrJ

Links:

Dr. John Cush @RheumNow( View Tweet )
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Best Rheumatologists (7.19.2024)

Jack Cush, MD

This week on the RheumNow Podcast, Dr. Jack Cush reviews the news and journal reports of interesting, including irAE, pollution and Psoriasis, microwave therapy, scleroderma without scleroderma that only the best rheumatologists could discern.

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PSS.scleroderma.arthritis.contractures

Updated EULAR Recommendations on the Treatment of Systemic Sclerosis

Medscape

Medscape has published an overview to the 2024 updated recommendations for the treatment of systemic sclerosis (SSc) presented in Vienna at EULAR 2024 by Professor Francesco Del Galdo, MD, PhD on behalf of a 27 member task force.

The new recommendations (n=20)

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scleroderma,month,organ,heart

Systemic sclerosis sine scleroderma

Jack Cush, MD

Systemic sclerosis sine scleroderma (ssSSc), which accounts for nearly 10% of systemic sclerosis (SSc) patients and was first described in 1962, is a subset of SSc.

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Dead Words Eulogy Cover Image

ICYMI: Dead Words Eulogy

Jack Cush, MD

The trouble with rheumatology may be the words we live by. Welcome to the eulogy for rheumatology 'dead words'. We're here today to celebrate the loss of rheumatology past. These are dead words in rheumatology, words fortified unfortunately by history and habit. The lexicon of rheumatology is

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EUSTAr study of 4431 systemic sclerosis (SSc) pts - anti-SSA antibodies are detected in 15% of SSc-patients and represent an independent risk factor for the presence of lung fibrosis (OR 1.24) & more severe lung involvement. #EULA2024 OP0013 https://t.co/NcxReWk83n https://t.co/FSMx22XiNo

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Dr. John Cush @RheumNow( View Tweet )
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Future Big BiTEs (6.28.2024)

Jack Cush, MD

Dr. Jack Cush reviews the news, journal articles and regulatory announcements from the past week on RheumNow.com.

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Finnish study of 331 systemic sclerosis (SSc) pts found that SSc is the major cause of death in diffuse & limited SSc. Among 91 deaths, the 5 & 10 year survival was 88% and 80%. Most common cause death was SSc (n=35)& ILD (13). https://t.co/m30CoAdsMN https://t.co/Ms9LN7eAUK

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Dr. John Cush @RheumNow( View Tweet )
EUSTAr study of 4431 systemic sclerosis (SSc) pts - anti-SSA antibodies are detected in 15% of SSc-patients and represent an independent risk factor for the presence of lung fibrosis (OR 1.24) & more severe lung involvement. #EULA2024 OP0013 https://t.co/oW6NBjIG7E https://t.co/toyvHxJlr9

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Dr. John Cush @RheumNow( View Tweet )
Rituximab vs. Tocilizimab for Scleroderma: Which is Better? Dr. Janet Pope discusses abstract OP0295 presented at Eular 2024 in Vienna, Austria. https://t.co/70YF2wxwj5 https://t.co/8BHCafFs3u

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Dr. John Cush @RheumNow( View Tweet )
New Treatments for Systemic Sclerosis aHSCT for SSc has been proven the most effective treatment strategy with regard to overall and event free survival in selected patients.2 But a key limitation is its toxicity, and new treatment options are needed. https://t.co/xUI0plrk42 https://t.co/DqGUhU6D1Z

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Dr. John Cush @RheumNow( View Tweet )
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New Treatments for Systemic Sclerosis

EurekAlert!

Autologous hematopoietic stem cell transplantation (aHSCT) for SSc has been proven the most effective treatment strategy with regard to overall and event free survival in selected patients.2 But a key limitation is its toxicity, and new treatment options are needed. Two abstracts

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#Scleroderma updated #EULAR2024 #recommendations @eular_org SKIN Are they good enough? Great work by task force @EUSTAR_org Do we alter initial Rx if v high mRSS? Ex #MMF not much improvement on skin vs #RTX #Cyclo Or combo Rx? We need to improve #SoC ?CAR-T ? RCT @RheumNow https://t.co/WhEzDdjVeu

Links:

Janet Pope @Janetbirdope( View Tweet )
#Scleroderma updated #EULAR2024 #recommendations @eular_org Are they good enough? Great work by task force @EUSTAR_org #PAH my thoughts Where does #sotaracept in #PAH fit in Not mentioned ?#selexipag before #epoprostenol For sure there is country variant @RheumNow https://t.co/3dJ6eusSkU

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Janet Pope @Janetbirdope( View Tweet )
Agree! Liz Volkmann said it straight Unsustainable RCTs in ILD trials in #scleroderma Why Can’t recruit ~same pool of early #dcSSc design RCT UNETHICAL a to have a progressing #scleroderma-ILD Pt on failed background #MMF + placebo for 1 yr 🙏🏻 #EULAR2024 @RheumNow @eular_org https://t.co/29oFEazwmM

Links:

Janet Pope @Janetbirdope( View Tweet )
#EULAR2024 OP0295 Approriate patient stratification matters in trials. H2H RCT of Tocilizumab vs Rituximab in refractory #SSc-ILD (failed CyC), stratified based on RNA-seq of lungs biopsy showed improved efficacy in TCZ with low B-cell lineage expression signature @RheumNow https://t.co/7ME3Bd2PeM

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
#EULAR2024 OP0288 Patients with Scleroderma shouldn’t be excluded from Lung Transplantation because of a concern with post-surgery complications/long term complications. Data from Italy of N=13 pts showed 93% survival, improved disesase activity & FVC over 2 years @RheumNow https://t.co/zPFB1MFxdc

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
#EULAR2024 OP0256 Phase 2 RCT ReSScue data of fecal microbiota transplantation did not meet primary endpoint (bloating & diarrhoea) in scleroderma. How about impact on faecal incontinence symptoms? This improved throughout 20wks. Could be due improved stool consistency @RheumNow https://t.co/1t7d3M5S4Z

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Md Yuzaiful Md Yusof @Yuz6Yusof( View Tweet )
#SARD #ILD Who to screen for #rheumatic #diseases For ILD #ACR guidelines Screening May also depend on ILD prevalence Not sure if frequency of screening and how to screen @jeffsparks #ORA24 @ORAexec https://t.co/BcyyYLKvr6

Links:

Janet Pope @Janetbirdope( View Tweet )
Review of the Scleroderma spectrum disorders (full-read) https://t.co/Z7cUrVeGRR https://t.co/VkYag0uZnX https://t.co/QK6bfcYBoF

Links:

Dr. John Cush @RheumNow( View Tweet )
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Is Cannabis Safe? (6.7.2024)

Jack Cush, MD

Dr. Jack Cush reviews FDA approval, news and journal articles -- and it’s the week before EULAR 2024 in Vienna!!

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Systemic sclerosis sine scleroderma in children is more aggressive than in adults. 18 juvenile vs 38 adults - ssJSSc more female (39% vs 89%), more digital pitting scars/ulcers (35 vs 10.5%), Pulm (50 vs 24) & CV (50 vs 3%); w/ more deaths https://t.co/l4f5bH1IX1 https://t.co/viQcD3tN9V

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Dr. John Cush @RheumNow( View Tweet )

Recent Blogs

Focus on the Fasting Lipid Profile

Dr Paul Anthony John Russo
Blood labs
How best do we communicate CV risk associated with RA to other members of the treating team, most particularly the primary care physicians? After some experimentation, I have come up with an approach that seems to work and which does not take up much time. Read Post

How Do I Treat Symptomatic Interstitial Lung Disease in Scleroderma?

Janet Pope, MD, MPH, FRCPC
IPF.lancet.jpg

Will the results of two recent large scleroderma lung studies finally inform us on how to manage interstitial lung disease in systemic sclerosis?  

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