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Infectious Mortality in Autoimmune Rheumatic Disorders

Infectious conditions are a significant cause of mortality in autoimmune rheumatic diseases (ARD). Among patients hospitalized with an infection, we compared in-hospital and long-term (3-year) mortality between those with and without ARD.

A retrospective cohort analysis of a large health maintenance organization in Israel analyzed adults hospitalized between 2003-2019. The outcomes were in-hospital mortality. Mortality outcomes in patients with ARD (subgroups) were compared to those without ARD. 

AS total of 365,247 ARD patients were admitted with a serious infection (SIE); this included 9755 RA, 1351 SLE, 2120 SpA, 584 systemic sclerosis, and 3214 vasculitis patients. 

Overall, the risk of in-hospital and 3-year mortality was not increased among those with ARD compared to those without ARD.  Yet, in matched multivariate analysis, the risk for in-hospital mortality was significantly ower in RA (OR 0.89) and and SpA (OR 0.77) and the 3-year mortality risk was lower RA (HR 0.82) and vasculitis (HR 0.86).

On the whole, ARD patients do not fair worse or die more than non-ARD patients when hospitalized for serious infections.


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The author has no conflicts of interest to disclose related to this subject