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Unique Oral Microbiome in Early and Pre-Clinical RA

May 06, 2021 4:31 pm

An oral microbiome study of rheumatoid arthritis (RA) patients suggests that periodontal condition in patients with early rheumatoid arthritis (ERA) and individuals at risk of RA.

A total of 150 RA patients from 3 different cohorts (ERA patients; at‐risk individuals (arthralgia and autoantibodies), and healthy controls) underwent periodontal exams and gingival pocket probing to assess between group differences.

While there were no differences in several periodontal variables, the microbial composition of saliva and tongue coating were significantly different between patients and controls. In ERA patients and at‐risk individuals, Prevotella in saliva and Veillonella in saliva and tongue coating were at higher relative abundance compared to healthy controls.

The oral microbiome is uniquely different in early RA patients, and such differences may exist prior to disease onset. 

The author has no conflicts of interest to disclose related to this subject

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