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Immunology

Potential OA Treatment - Chemokine CCL17 Inhibition

MedPage Today

Patients with osteoarthritis (OA) of the knee receiving an investigational chemokine inhibitor showed some improvements in pain and disability, said researchers with the drug's developer.

In a phase I study that also included placebo-controlled efficacy testing, Western Ontario and

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Biomarker substudy of #SLE Rx w/ low dose IL-2 Rx in 342 pts (40% responders). SRI-4 predicted by rash, proteinuria, uRBC, %CD4 T cells, C3 (AUC 0.9330; however renal markers did not correlate with achieving LLDAS. https://t.co/pDgwegbU6t https://t.co/72w4gNAiWt
Dr. John Cush @RheumNow( View Tweet )
ANA+ consult (10.18.2024) Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow. https://t.co/cH4s99Fzka https://t.co/kNcUqahmeS
Dr. John Cush @RheumNow( View Tweet )
RBC mitochondrial DNA triggers type I interferon (IFN) production in macrophages leading to production of interleukin-1β and inflammasome activation - Making IFN & IL-1B monocytes another potential therapeutic target in #SLE https://t.co/za878eodKS https://t.co/NomRDJTm0u https://t.co/nLB189HeNi
Dr. John Cush @RheumNow( View Tweet )

ANA+ consult (10.18.2024)

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

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GWAS study of 2.6 million people (120,295 w/ prevalent gout) detected 377 loci & 410 independent genes (149 prev unreported), includes genes of inflammation, epigenetic remodeling, cell osmolarity, NLRP3 activity, & clonal hematopoiesis (CHIP) https://t.co/GmXWtTlJkO https://t.co/xPK2Iy3NRj
Dr. John Cush @RheumNow( View Tweet )

Inadequate Zoster Vaccination in Immunocompromised Patients

A VA study of shows that recombinant zoster vaccine (RZV) vaccination in immunocompromised patients or those receiving immunosuppressive medications is insufficient, given these are high risk individuals.

The recombinant zoster vaccine (RZV; or "Shingrix") was FDA approved In 2017 for

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Dot the "i", Cross the "t" (10.11.2024)

Dr. Jack Cush reviews the news and journal articles from the past week on RheumNow.com. Today’s reports suggest where to look for help, especially with regard to pain.

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Mucosal Disruptions as Initiators of Rheumatoid Arthritis The microbiome and mucosal disruptions are believed to play a role in autoimmunity, particularly rheumatoid arthritis (RA). This is linked to the "mucosal hypothesis" of RA. A recent review by Hollers, et al. discusses… https://t.co/79khnkajMy https://t.co/UvZWwJ3ERg
Dr. John Cush @RheumNow( View Tweet )
JCI article on Mechanisms underlying sex differences in autoimmunity - factors include sex hormones, X chromosome genes, sex-specific epigenetic effects of estrogen & environment, and microRNA effects. Also mitochondria & autoantibodies discussed https://t.co/hTrizE8jFK https://t.co/VixAZsYBzb
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Stop Counting Bugs (10.4.2024) This week’s rants include the microbiome, PsA treatment choices and fishing for P-values in research. https://t.co/KRoMltgPeM https://t.co/9uAbqV8PDK
Dr. John Cush @RheumNow( View Tweet )

Mucosal Disruptions as Initiators of Rheumatoid Arthritis

Many have suggested that microbiome and mucosal disruptions are contributors to autoimmunity, especially rheumatoid arthritis (RA). This is partly represented in what is known as the "mucosal hypothesis" to RA. A current review article by Hollers, et al. addresses how distinct mucosal endotypes

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Full read review of Pathogenic autoantibodies in idiopathic inflammatory myopathies: antisynthetase autoAbs, TIF1, MDA5, SRP, HMGCR, TRIM72, cN1A, FHL1, eIF3 autoantibodies and more https://t.co/uzCmauulWZ https://t.co/twhwCB4xof
Dr. John Cush @RheumNow( View Tweet )
Study of oral microbiota & psoriasis (72 PSO vs 16 healthy controls) - 16S rRNA gene sequencing of saliva found (in PSO) signif incrCapnocytandophaga, Campylobacter, Acetobacter, but decr Bacteroides, Muribaculaceae. PSA pts incr Aggregatibacter, but decr Prevotella… https://t.co/GukbWkl1Gz https://t.co/HgLcD6bP2I
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🌟 ACUTE OPTIC NEURITIS - Differentials https://t.co/eE1Kbnmqc1
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Neoself-antigens are targeted by autoreactive T cells clonally expanded in SLE. Neoself-antigen presentation results in clonally expanded neoself-reactive T cells, leading to the development of lupus-like disease in mice. https://t.co/iFXNLNRxO5 https://t.co/9TEJUqfEbo
Dr. John Cush @RheumNow( View Tweet )

I Can't Treat Ugly (9.20.2024)

Dr. Jack Cush reviews the news, journal articles and a new FDA approval for EGPA, this week on the Podcast.

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Congratulations to UCF Associate Professor Justine Tigno-Aranjuez for receiving prestigious U.S. National Science Foundation CAREER Award on her research into NOD2 receptor signaling of lipid mediators contributing to inflammation https://t.co/AkUZbdTSqF https://t.co/usTe2bzyXE
Dr. John Cush @RheumNow( View Tweet )
Animal model shows Aggregatibacter actinomycetemcomitans periodontitis can trigger macrophage/caspase-11/inflammasome activation leading to paw swelling in mice anti-collagen antibody-induced arthritis (CAIA) model https://t.co/f41r28g5yr https://t.co/61NeXgfzmB
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Systemic Sclerosis Insights (9.13.2024)

Dr. Jack Cush reviews the news and journal articles from this past week on RheumNow.com.

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In elderly onset rheumatoid arthritis, Treg cells are increased, but have decr suppressor activity. Maybe due to elevated Type I IFN with IFN-β suppressing old Tregs and increasing PD-1 expression. https://t.co/51ww481FkJ https://t.co/8EA1fENaFm
Dr. John Cush @RheumNow( View Tweet )

Linger on the Fingers (9.6.2024)

Dr. Jack Cush reviews the news and journal reports from the past week on RheumNow.com. This week with a focus on fingers and better prescriptive follow through.

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CAR-T Like Effects with Bispecific Teclistamab

MedPage Today

A new chapter may have begun in the exciting story of "immune reset" therapy for difficult-to-treat autoimmune diseases, with a patient with severe refractory lupus obtaining drug-free remission after treatment with an antibody product normally used in multiple myeloma.

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Diagnosing Seronegative Sjogren's Disease

Sjögren disease (SjD) is highly prevalent, but diagnosis may be challenged if anti-SSA antibodies or a labial salivary gland biopsy are negative. A recent cohort analysis suggests a novel autoantibody profile has predictive value SSA negative SjD and also in those with a positive labial biopsy

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Antibiotics May Increase Inflammatory Arthritis Risk

A Danish registry study has shown that amongst those patients who develop inflammatory arthritis (IA), antibiotics use was more frequent when compared to the background population (BP). 

This isn't the first time this association between antibiotic usage and futher

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