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Immunology

#EULAR2021 LB0002 #COVID vax safety in RMD ⭐️78% received Pfizer, 16% Astra Zeneca ⭐️5% of pts flares, 1.2% severe flares ⭐️31% had vax side effects, 0.1% severe AEs Side effect profile similar to gen population. Good data for uncertain patients! @RheumNow @rheum_covid https://t.co/PGZcph9Mu6
Eric Dein @ejdein1( View Tweet )
Jun 05, 2021
#EULAR2021 and EULAR IQ Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021. https://t.co/BkHjhOUqNU https://t.co/4JS1yGiJHg
Dr. John Cush @RheumNow( View Tweet )
Jun 05, 2021

RheumNow Podcast - EULAR 2021 & EULAR-IQ (6.4.21)

Jun 04, 2021

Dr Jack Cush reviews highlight presentations from the first 3 days of EULAR 2021.


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OP0186 #EULAR2021 by Dr. Mariele Gatto. Anti-cancer effect of immunotherapy with ICI is believed to be mediated by CD8 positive Tc cells. It is not known if other cells get activated. This study looks at B cells. Transitional B cells ⬆️ in ICI induced arthritis (CP-IA). /TK https://t.co/szFF81SKVL
ARD & RMD Open @ARD_BMJ( View Tweet )
Jun 03, 2021
So how do irAEs work? Dr. Anne Bass @lovetolearn27 @HSpecialSurgery gives #EULAR2021 a possible conceptual framework @LCalabreseDO @CCalabreseDO @cappelliMD @got_rheum @MarieKostine and so many other good people! @RheumNow https://t.co/5eOZDwkGO6
David Liew @drdavidliew( View Tweet )
Jun 03, 2021
Excellent talk by @LCalabreseDO on the balance of the immune response! ⭐️Exhausted T cells seen in rheumatic dz, chronic infections, cancers, severe COVID-19 ⭐️CPI for treatment of latent infections? CPI for treatment of COVID? 🤔 Abs#OP7137 #EULAR2021 @RheumNow https://t.co/18rvFkpPTx
Robert B Chao, MD @doctorRBC( View Tweet )
Jun 02, 2021
Andrew Ostor @AbbVie symposium @eular_org presented HZ vaccines are safe in RA pts with #JAKi but with Recombinant HZ vaccine humeral response - 75% in RA pts in JAKi vs 100% controls. So should we hold JAKi with Shringix & if so for 1 or 2 wks? #EULAR2021 @RheumNow https://t.co/wVOFMa9fLm
Janet Pope @Janetbirdope( View Tweet )
Jun 02, 2021
Lifetime risk of HZ is 30%! ⬆️ in pts with immune diseases or immunesuppression. All #JAKI ⬆️ risk maybe doubling but NNH & NNT give context. UPA Rx in active RA -20 more pts in remission vs 1 excess HZ if comparing UPA to ADA in RA @RheumNow #EULAR2021 AbbVie symposium https://t.co/14i0IsIpzs
Janet Pope @Janetbirdope( View Tweet )
Jun 02, 2021
Starting Thursday we'll be covering EULAR. Tune in for coverage on KOL perspective highlights, clinical trial highlights and much more. https://t.co/L7ryiQ5HdV
Dr. John Cush @RheumNow( View Tweet )
Jun 01, 2021
Unable to attend the Tuesday Night Rheumatology on RA and vaccines? Watch the replay below. https://t.co/hUFTjDAnsg https://t.co/ywCRjqg1To
Dr. John Cush @RheumNow( View Tweet )
May 27, 2021

Tocilizumab Augmented Efficacy in COVID-19 Pneumonia with High CRP

May 25, 2021

JAMA Internal Medicine report an analysis of recent and composite trial data suggesting that tocilizumab (TCZ) therapy in COVID-19–associated pneumonia patients with high CRP levels is likely to be effective.

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RheumNow Live 2021 Now Available for All

May 14, 2021

RheumNow Live (RNL) for 2021 was held March 20 - 21 in Fort Worth, TX, and now all can partake in the meeting - by video, podcast or by signing up for Tuesday Nite Rheumatology (TNR).



RNL has finished its 3rd year as a hybrid meeting, with the live meeting streamed to hundreds at home

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Unique Oral Microbiome in Early and Pre-Clinical RA

May 06, 2021

An oral microbiome study of rheumatoid arthritis patients suggests that periodontal condition in patients with early rheumatoid arthritis and individuals at risk of RA.

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Autoimmune Thyroid Disease in Women

May 04, 2021

JAMA has posted an insights article reviewing autoimmune thyroid disease in women. Thyroid autoimmunity has a higher prevalence in women and with increasing age.



Similar to many autoimmune disorders, thyroid disease is more common in women than in men.

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Uric Acid: A Major Player in the Metabolic Syndrome

May 03, 2021

An open source, free read from the European Journal of Internal Medicine discusses how uric acid has evolved from the toxic cause of gout and nephrolithiasis and evolved, by way of science, into a pleiotropic recidivist in the evolution of obesity, diabetes, insulin resistance, renal disease,

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Inflammatory Conditions Up the Risk of Premature Myocardial Infarction

Mar 31, 2021

The European Journal of Preventive Cardiology reports that younger patients with their first myocardial infarction before age 50 yrs have a higher risk of having a systemic inflammatory disease (SIDs) and higher rates all-cause mortality.



Data derived from the retrospective

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Serious Infections Still Common in Vasculitis

MedPage Today
Mar 29, 2021

Serious infections occurred more frequently among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis who were given induction therapy with cyclophosphamide compared with rituximab (Rituxan), Greek researchers found.

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RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Mar 22, 2021

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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NEJM: Interleukin-6 Inhibition in Critically-Ill COVID-19

Mar 01, 2021

The pendulum and jury are wavering with regard to the benefits of interleukin-6 receptor antagonists in COVID-19; the current NEJM reports the results of a study favoring such biologic therapy in in critically ill COVID-19 patients.

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RheumNow Podcast – Systemic Sclerosis Pearls (2.19.2021)

Feb 18, 2021

Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on RheumNow.com, including the ACR's new COVID-19 vaccine guidance for patients with rheumatic disease.

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MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout

Feb 15, 2021

Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout.

This exploratory, open-label clinical trial screened 17 patients and treated 14 patients (all men, 49.3 ± 8.7 years) with IV pegloticase with MTX (15

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RWCS Highlights - Day 3

Feb 15, 2021

Day 3 report from the 2021 RWCS meeting in Maui (and virtually) includes pearls from the PsA 2020 Year in Review; fact vs. fiction on evidence based medicine: diet and rheumatic diseases; hot topics in allergy/immunology; and pediatric rheumatology highlights.

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Synovial Tissue Signature Guiding Targeted IL-6 Therapy in RA

Feb 09, 2021

RNA sequencing and classification of RA subsets has proven useful. RNA sequencing-based stratification of RA synovial tissue showed stronger associations with clinical responses compared with histopathological classification. Additionally, for patients with low or absent B-cell lineage

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Vagal Nerve Stimulation in Rheumatoid Arthritis

Feb 02, 2021

Lancet Rheumatology has reported the results of a proof of concept trial, wherein vagal nerve stimulation was shown to ameliorate RA disease activity. The intervention involved non-invasive stimulation of the auricular branch of the vagus nerve using a wearable vagus nerve stimulation device for

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Download available--Maintaining a Healthy Immune System https://t.co/wiWzZldnik https://t.co/ZL3r3dHPC2
Dr. John Cush @RheumNow( View Tweet )
Feb 01, 2021
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