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Immunology

Inflammatory Conditions Up the Risk of Premature Myocardial Infarction

Mar 31, 2021

The European Journal of Preventive Cardiology reports that younger patients with their first myocardial infarction before age 50 yrs have a higher risk of having a systemic inflammatory disease (SIDs) and higher rates all-cause mortality.



Data derived from the retrospective

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Serious Infections Still Common in Vasculitis

MedPage Today
Mar 29, 2021

Serious infections occurred more frequently among patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis who were given induction therapy with cyclophosphamide compared with rituximab (Rituxan), Greek researchers found.

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RECIPE Trial - Mycophenolate to Suppress Immunogenicity with Pegloticase in Gout

Mar 22, 2021

Pegloticase is indicated in the treatment of severe gout patients but prolonged use may be limited by immunogenicity to the PEG moiety. A randomized, controlled trial has shown that concomitant mycophenolate mofetil (MMF) may prolong the efficacy of pegloticase in gout.

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NEJM: Interleukin-6 Inhibition in Critically-Ill COVID-19

Mar 01, 2021

The pendulum and jury are wavering with regard to the benefits of interleukin-6 receptor antagonists in COVID-19; the current NEJM reports the results of a study favoring such biologic therapy in in critically ill COVID-19 patients.

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RheumNow Podcast – Systemic Sclerosis Pearls (2.19.2021)

Feb 18, 2021

Dr. Jack Cush reviews nearly a dozen news and journal reports from the past 2 weeks on RheumNow.com, including the ACR's new COVID-19 vaccine guidance for patients with rheumatic disease.

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MIRROR Study: Pegloticase With Methotrexate in Uncontrolled Gout

Feb 15, 2021

Botson et al has reported that the combination of methotrexate (MTX) and IV pegloticase is safe and effective in patients with uncontrolled gout.

This exploratory, open-label clinical trial screened 17 patients and treated 14 patients (all men, 49.3 ± 8.7 years) with IV pegloticase with MTX (15

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RWCS Highlights - Day 3

Feb 15, 2021

Day 3 report from the 2021 RWCS meeting in Maui (and virtually) includes pearls from the PsA 2020 Year in Review; fact vs. fiction on evidence based medicine: diet and rheumatic diseases; hot topics in allergy/immunology; and pediatric rheumatology highlights.

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Synovial Tissue Signature Guiding Targeted IL-6 Therapy in RA

Feb 09, 2021

RNA sequencing and classification of RA subsets has proven useful. RNA sequencing-based stratification of RA synovial tissue showed stronger associations with clinical responses compared with histopathological classification. Additionally, for patients with low or absent B-cell lineage

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Vagal Nerve Stimulation in Rheumatoid Arthritis

Feb 02, 2021

Lancet Rheumatology has reported the results of a proof of concept trial, wherein vagal nerve stimulation was shown to ameliorate RA disease activity. The intervention involved non-invasive stimulation of the auricular branch of the vagus nerve using a wearable vagus nerve stimulation device for

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Download available--Maintaining a Healthy Immune System https://t.co/wiWzZldnik https://t.co/ZL3r3dHPC2
Dr. John Cush @RheumNow( View Tweet )
Feb 01, 2021
UTSW Rheum Grand Rounds - IgG4 Dz - Plasmablasts may be a useful biomarker; but is not generally available in clinical labs (must be done on fresh whole blood) @UTSWIMchief https://t.co/GlEKw0KD3O
Dr. John Cush @RheumNow( View Tweet )
Jan 21, 2021
New Download Available on COVID-19 & mRNA Vaccines https://t.co/mvmn17Fl3B https://t.co/ceICzbDZi5
Dr. John Cush @RheumNow( View Tweet )
Jan 17, 2021

2020 Rheumatology Year in Review

Jan 14, 2021

2020 was historic, memorable and game-changing. Under the cloud of COVID-19, there were many significant and memorable advances and setbacks for the rheumatology world. In our accounting of most read articles for 2020, (not surprisingly) 17/20 were COVID-related. Below, are our top news items

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ProDERM Study: IVIG in Dermatomyositis

Jan 13, 2021

The ProDERM study design and outcomes are previewed in Medicine; and as promised the results were revealed at ACR Convergence in November 2020 showing that IVIg is safe, effective and superior to placebo i(PBO) in patients with dermatomyositis (DM).

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Adipose Transplants as a New Regulator of Osteoarthritis

Jan 11, 2021

A novel report from PNAS suggests that in osteoarthritis (OA), the damage is not entirely from body weight and mechanics, instead it may be from adipose tissue itself.

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Best of 2020: ACR 2020 Reproductive Guidelines - Contraception & Counseling

Dec 29, 2020

The American College of Rheumatology established a guidelines committee that consisted of both patients, rheumatologists and maternal-fetal health experts. After a a systematic review of the medical literature regarding contraception, assisted reproductive technology, fertility preservation,

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Benlysta First Agent Approved for Lupus Nephritis

Dec 17, 2020

After the successful completion of the BLISS-LN trial and previewing the results at EULAR 2020 and ACR Convergence, GlaxoSmithKline announced yesterday that the FDA has approved belimumab (Benlysta) for use in adults with active lupus nephritis (LN) receiving background/standard therapy.

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#BestACR20Tweets RT @RichardPAConway : Dr Kaellmark reports on immunogenicity of adjuvant herpes zoster subunit vaccine in RA patients treated with JAKi. 40 RA patients and 20 controls. Satisfactory serological responses and tolerability seen. @rheumnow #ACR20 Abstr#1997 https://t.co/TR9IS9hUgu
Dr. John Cush @RheumNow( View Tweet )
Dec 07, 2020
Check on Pneumococcal Vaccination: Dr. Janet Pope ( @Janetbirdope) #ACR20 https://t.co/D9EQ3Tl2Ot https://t.co/Zn8IVorCcs
Dr. John Cush @RheumNow( View Tweet )
Dec 01, 2020
#BestACR20Tweets RT @RADoctor: Adjuvant #herpeszoster vaccine (Shingrix) not effective for 25% of JAKi-treated RA pts (n=40) for antibody response (T cell response usually worse, not reported). Is better than nothing good enough? Maybe we need to hold JAKi briefly?

Dr. John Cush @RheumNow( View Tweet )

Nov 30, 2020
Vaccination with Shingrix: Does it work for patients on JAKi? #ACR20 https://t.co/PLWn3SshcI https://t.co/APBcfP1zlH
Dr. John Cush @RheumNow( View Tweet )
Nov 25, 2020

Vaccination with Shingrix: Does it work for patients on JAKi?

Dr. Jeffrey Curtis examines abstracts #1997 and #0452 presented at the ACR 2020 annual meeting.

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Great read! "The Vaccine Review Process and Why You Should Know It" by Dr. Rachel Tate ( @uptoTate) https://t.co/l39qH3LuXm https://t.co/PR1AaQCD7V
Dr. John Cush @RheumNow( View Tweet )
Nov 19, 2020

Flu and Tofacitinib

Nov 19, 2020

Dr. Kathryn Dao reviews abstract L04 - Influenza Adverse Events in Patients with Rheumatoid Arthritis in the Tofacitinib Clinical Program - at the 2020 ACR annual meeting.

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The Vaccine Review Process and why you should know it

Nov 16, 2020

There is much controversy regarding vaccine safety and efficacy in the United States. Prior to COVID19, there were populations who lacked confidence in vaccination for any number of reasons. Dr. Grace Lee presented a great overview of the vaccination recommendation to adoption framework that

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