Pregnancy-Related Deaths in the US

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A CDC cross-sectional national study showed an increase in pregnancy-related deaths in the US from 2018 to 2022, with highest rates among American Indian, Alaska Native women, and non-Hispanic Black women. 

Yoga vs Strengthening Exercise in Knee Osteoarthritis

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A randomized clinical trial in knee osteoarthritis (KOA) patients showed both yoga and strengthening improved knee pain over 12 weeks, with no difference between groups.

RA Prevention through Deep Immunophenotyping

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Researchers at the University of Colorado have identified pathogenic immune phenotypes in at-risk populations for rheumatoid arthritis (RA).

Uveitis Risk with Slow Adalimumab Weaning

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Patients with pediatric non-infectious uveitis (NIU) who achieved remission on adalimumab (Humira) had lower recurrence rates when the drug was withdrawn more gradually, a retrospective cohort analysis indicated.

ACP: Best Practice Advice on Cannabis or Cannabinoids Use for Chronic Noncancer Pain

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The American College of Physicians published a best practice advisory on cannabis or cannabinoids in the Annals of Internal Medicine.

Mindfulness and CBT improve chronic low back pain

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Behavioral interventions were associated with reduced pain and daily opioid use and improved function and quality of life for up to 12 months among adults with opioid-treated chronic low back pain, according to a new randomized clinical trial.

An Epidural Letdown (4.4.2025)

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Dr. Jack Cush reviews the news and journal reports from this past week on RheumNow.com.

Vamorolone: a New Steroid on the Horizon?

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Steroids, Prophylaxis and Pneumocystis Pneumonia

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A case-control study has shown that glucocorticoids and tapering glucocorticoids are risk factors for the development of Pneumocystis jirovecii pneumonia (PJP).

Upadacitinib for Giant-Cell Arteritis - A Phase 3 Trial

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The NEJM has published a randomized controlled trial in giant-cell arteritis (GCA) patients, demonstrating significant efficacy and safety of upadacitinib (UPA), given as 15 mg daily, as compared to placebo. 

 

Diagnostic delays and Undertreatment of Psoriatic Arthritis

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New research from the University of Bath in the UK reveals delayed diagnosis and undertreatment of psoriatic arthritis often results in irreversible damage to joints.

Joint Implant Metals May Be Leaking

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Patients with metal-containing joint replacements had significantly higher concentrations of cobalt in their cerebrospinal fluid (CSF) relative to patients without arthroplasties, researchers reported.